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Protein

MAP kinase kinase mkk-4

Gene

mkk-4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Activity is required in presynaptic neurons, in a dose-dependent manner, for normal presynaptic development and morphology (PubMed:15707898). Plays a role in the formation of muscle connections, also called muscle arm extensions, between the body wall and the motor axons in the dorsal and ventral cord (PubMed:27123983).2 Publications

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei95ATPPROSITE-ProRule annotation1
Active sitei194Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi72 – 80ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • activation of MAPK activity Source: UniProtKB
  • axon regeneration Source: UniProtKB
  • MAPK cascade involved in axon regeneration Source: WormBase
  • positive regulation of axon extension involved in regeneration Source: UniProtKB
  • regulation of apoptotic process Source: GO_Central
  • regulation of mitotic cell cycle Source: GO_Central
  • regulation of synapse organization Source: WormBase
  • regulation of synaptic growth at neuromuscular junction Source: UniProtKB
  • stress-activated protein kinase signaling cascade Source: GO_Central

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-2559580 Oxidative Stress Induced Senescence
R-CEL-2871796 FCERI mediated MAPK activation
R-CEL-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
SignaLinkiQ20347

Names & Taxonomyi

Protein namesi
Recommended name:
MAP kinase kinase mkk-4 (EC:2.7.12.2)
Gene namesi
Name:mkk-4
ORF Names:F42G10.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiF42G10.2 ; CE10328 ; WBGene00003368 ; mkk-4

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Disruption phenotypei

Defective extension of body wall muscle connections or arms towards the ventral nerve cord. Double knockout with madd-3 results in severe muscle arm extension defects.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000868421 – 363MAP kinase kinase mkk-4Add BLAST363

Proteomic databases

EPDiQ20347
PaxDbiQ20347
PeptideAtlasiQ20347
PRIDEiQ20347

Expressioni

Gene expression databases

BgeeiWBGene00003368

Interactioni

GO - Molecular functioni

  • mitogen-activated protein kinase kinase kinase binding Source: WormBase

Protein-protein interaction databases

BioGridi50442, 6 interactors
DIPiDIP-25523N
IntActiQ20347, 3 interactors
STRINGi6239.F42G10.2

Structurei

3D structure databases

ProteinModelPortaliQ20347
SMRiQ20347
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini66 – 330Protein kinasePROSITE-ProRule annotationAdd BLAST265

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0984 Eukaryota
ENOG410XT3F LUCA
GeneTreeiENSGT00760000119199
HOGENOMiHOG000234206
InParanoidiQ20347
KOiK04430
OMAiVMKSNDC
OrthoDBiEOG091G0A9H
PhylomeDBiQ20347

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q20347-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQEDDENLR NSMSLRPTSL STRPTSLSVN GNEKTLPEES VLRSLSTGTL
60 70 80 90 100
KYPDDEHLYT FSSANLQDLG AIGNGNFGTV YKMRHKETGK LIAVKRIRCN
110 120 130 140 150
NIGHREQIRL LREHDTIVKS EKGPNIVKFY GAIFSEGDCW ICMELMDISM
160 170 180 190 200
DLLYKRVYMV KNSRLNENVV GHITVCTVDA LDYLKKELKI IHRDVKPSNI
210 220 230 240 250
LVDGTGAVKL CDFGICGQLE ESFAKTHDAG CQPYLAPERI TSSDKYDVRS
260 270 280 290 300
DVWSLGITLY EIATGKFPYQ EWNSLFDQIA TVVSGDPPIL HPDSDDFHYS
310 320 330 340 350
LPLVKFINTC LTKDRRHRPK YDTLKSFDFY RIYAVAGPEI EEAKRILGVE
360
AIDTRNHPVD HRG
Length:363
Mass (Da):41,197
Last modified:July 15, 1998 - v3
Checksum:i643A26A23329759A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48230, Z95122 Genomic DNA Translation: CAA88264.1
PIRiT22107
RefSeqiNP_509682.1, NM_077281.4
UniGeneiCel.1019

Genome annotation databases

EnsemblMetazoaiF42G10.2; F42G10.2; WBGene00003368
GeneIDi185682
KEGGicel:CELE_F42G10.2
UCSCiF42G10.2 c. elegans

Similar proteinsi

Entry informationi

Entry nameiMKK4_CAEEL
AccessioniPrimary (citable) accession number: Q20347
Secondary accession number(s): O01707
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: May 23, 2018
This is version 143 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

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