Reviewed,
UniProtKB/Swiss-Prot Q20347 (MKK4_CAEEL)
Last modified
November 3, 2009.
Version 74.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: MAP kinase kinase mkk-4 EC=2.7.12.2 | ||||
| Gene names |
| ||||
| Organism | Caenorhabditis elegans [Complete proteome] | ||||
| Taxonomic identifier | 6239 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Protein attributes
| Sequence length | 363 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Activity is required in presynaptic neurons, in a dose-dependent manner, for normal presynaptic development and morphology. Ref.2 |
| Catalytic activity | ATP + a protein = ADP + a phosphoprotein. |
| Subcellular location | |
| Sequence similarities | Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. Contains 1 protein kinase domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Serine/threonine-protein kinase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein bindingInferred from physical interaction. Source: IntAct protein serine/threonine kinase activityInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| jnk-1 | Q8WQG9 | 1 | EBI-321815,EBI-321822 | |
| kel-8 | O61899 | 1 | EBI-321815,EBI-312469 | |
| kgb-1 | O44408 | 1 | EBI-321815,EBI-319489 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 363 | 363 | MAP kinase kinase mkk-4 | PRO_0000086842 | |||||
Regions | |||||||||
| Domain | 66 – 330 | 265 | Protein kinase | ||||||
| Nucleotide binding | 72 – 80 | 9 | ATP By similarity | ||||||
Sites | |||||||||
| Active site | 194 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 95 | 1 | ATP By similarity | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2. |
| [2] | "Regulation of a DLK-1 and p38 MAP kinase pathway by the ubiquitin ligase RPM-1 is required for presynaptic development." Nakata K., Abrams B., Grill B., Goncharov A., Huang X., Chisholm A.D., Jin Y. Cell 120:407-420(2005) [PubMed: 15707898] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| Z95122, Z48230 Genomic DNA. Translation: CAB08355.1. Z48230, Z95122 Genomic DNA. Translation: CAA88264.1. | |
| PIR | T22107. |
| RefSeq | NP_509682.1. |
| UniGene | Cel.1019 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP:25523N. |
| IntAct | Q20347. 6 interactions. |
| STRING | Q20347. |
Genome annotation databases | |
| Ensembl | F42G10.2; F42G10.2; F42G10.2; Caenorhabditis elegans. [Genome view] |
| GeneID | 185682. |
| KEGG | cel:F42G10.2. |
| NMPDR | fig|6239.3.peg.24349. |
| UCSC | F42G10.2. c. elegans. |
Organism-specific databases | |
| CTD | 185682. |
| WormBase | WBGene00003368. mkk-4. |
| WormPep | F42G10.2. CE10328. [WorfDB] |
Phylogenomic databases | |
| OMA | PYLAPER. |
Enzyme and pathway databases | |
| BRENDA | 2.7.12.2. 672. |
Gene expression databases | |
| ArrayExpress | Q20347. |
Family and domain databases | |
| InterPro | IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. [Graphical view] |
| Pfam | PF00069. Pkinase. 1 hit. [Graphical view] |
| ProDom | PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| PROSITE | PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 929126. |
Entry information
| Entry name | MKK4_CAEEL | ||||||||
| Accession | Primary (citable) accession number: Q20347 Secondary accession number(s): O01707 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Caenorhabditis annotation project | ||||||||
Relevant documents
| Caenorhabditis elegans Caenorhabditis elegans: entries, gene names and cross-references to WormPep |
| SIMILARITY comments Index of protein domains and families |

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