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Protein

MAP kinase kinase mkk-4

Gene

mkk-4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Activity is required in presynaptic neurons, in a dose-dependent manner, for normal presynaptic development and morphology.1 Publication

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei95 – 951ATPPROSITE-ProRule annotation
Active sitei194 – 1941Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi72 – 809ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • activation of MAPK activity Source: WormBase
  • axon regeneration Source: UniProtKB
  • MAPK cascade involved in axon regeneration Source: UniProtKB
  • regulation of synapse organization Source: WormBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-CEL-2559580. Oxidative Stress Induced Senescence.
R-CEL-2871796. FCERI mediated MAPK activation.
R-CEL-450321. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
SignaLinkiQ20347.

Names & Taxonomyi

Protein namesi
Recommended name:
MAP kinase kinase mkk-4 (EC:2.7.12.2)
Gene namesi
Name:mkk-4
ORF Names:F42G10.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiF42G10.2; CE10328; WBGene00003368; mkk-4.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: WormBase
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 363363MAP kinase kinase mkk-4PRO_0000086842Add
BLAST

Proteomic databases

PaxDbiQ20347.
PRIDEiQ20347.

Expressioni

Gene expression databases

BgeeiWBGene00003368.

Interactioni

GO - Molecular functioni

  • mitogen-activated protein kinase kinase kinase binding Source: WormBase

Protein-protein interaction databases

BioGridi50442. 6 interactions.
DIPiDIP-25523N.
IntActiQ20347. 3 interactions.
MINTiMINT-1043930.
STRINGi6239.F42G10.2.

Structurei

3D structure databases

ProteinModelPortaliQ20347.
SMRiQ20347. Positions 25-340.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini66 – 330265Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0984. Eukaryota.
ENOG410XT3F. LUCA.
GeneTreeiENSGT00760000119199.
HOGENOMiHOG000234206.
InParanoidiQ20347.
KOiK04430.
OMAiAWICMEL.
OrthoDBiEOG091G0A9H.
PhylomeDBiQ20347.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q20347-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVQEDDENLR NSMSLRPTSL STRPTSLSVN GNEKTLPEES VLRSLSTGTL
60 70 80 90 100
KYPDDEHLYT FSSANLQDLG AIGNGNFGTV YKMRHKETGK LIAVKRIRCN
110 120 130 140 150
NIGHREQIRL LREHDTIVKS EKGPNIVKFY GAIFSEGDCW ICMELMDISM
160 170 180 190 200
DLLYKRVYMV KNSRLNENVV GHITVCTVDA LDYLKKELKI IHRDVKPSNI
210 220 230 240 250
LVDGTGAVKL CDFGICGQLE ESFAKTHDAG CQPYLAPERI TSSDKYDVRS
260 270 280 290 300
DVWSLGITLY EIATGKFPYQ EWNSLFDQIA TVVSGDPPIL HPDSDDFHYS
310 320 330 340 350
LPLVKFINTC LTKDRRHRPK YDTLKSFDFY RIYAVAGPEI EEAKRILGVE
360
AIDTRNHPVD HRG
Length:363
Mass (Da):41,197
Last modified:July 15, 1998 - v3
Checksum:i643A26A23329759A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48230, Z95122 Genomic DNA. Translation: CAA88264.1.
PIRiT22107.
RefSeqiNP_509682.1. NM_077281.4.
UniGeneiCel.1019.

Genome annotation databases

EnsemblMetazoaiF42G10.2; F42G10.2; WBGene00003368.
GeneIDi185682.
KEGGicel:CELE_F42G10.2.
UCSCiF42G10.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48230, Z95122 Genomic DNA. Translation: CAA88264.1.
PIRiT22107.
RefSeqiNP_509682.1. NM_077281.4.
UniGeneiCel.1019.

3D structure databases

ProteinModelPortaliQ20347.
SMRiQ20347. Positions 25-340.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi50442. 6 interactions.
DIPiDIP-25523N.
IntActiQ20347. 3 interactions.
MINTiMINT-1043930.
STRINGi6239.F42G10.2.

Proteomic databases

PaxDbiQ20347.
PRIDEiQ20347.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF42G10.2; F42G10.2; WBGene00003368.
GeneIDi185682.
KEGGicel:CELE_F42G10.2.
UCSCiF42G10.2. c. elegans.

Organism-specific databases

CTDi185682.
WormBaseiF42G10.2; CE10328; WBGene00003368; mkk-4.

Phylogenomic databases

eggNOGiKOG0984. Eukaryota.
ENOG410XT3F. LUCA.
GeneTreeiENSGT00760000119199.
HOGENOMiHOG000234206.
InParanoidiQ20347.
KOiK04430.
OMAiAWICMEL.
OrthoDBiEOG091G0A9H.
PhylomeDBiQ20347.

Enzyme and pathway databases

ReactomeiR-CEL-2559580. Oxidative Stress Induced Senescence.
R-CEL-2871796. FCERI mediated MAPK activation.
R-CEL-450321. JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.
SignaLinkiQ20347.

Miscellaneous databases

PROiQ20347.

Gene expression databases

BgeeiWBGene00003368.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMKK4_CAEEL
AccessioniPrimary (citable) accession number: Q20347
Secondary accession number(s): O01707
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: July 15, 1998
Last modified: September 7, 2016
This is version 128 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.