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Protein

Protein lin-49

Gene

lin-49

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Essential protein required to maintain expression of homeotic genes egl-5 and mab-5. May play an analogous role to the trithorax Group (trxG) proteins. TrxG proteins form multiprotein complexes that are required to maintain the transcriptionally active state of homeotic genes throughout development. May act via a modification of chromatin.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri195 – 245PHD-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri249 – 282C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST34
Zinc fingeri306 – 366PHD-type 2PROSITE-ProRule annotationAdd BLAST61

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein lin-49
Alternative name(s):
Abnormal cell lineage protein 49
Gene namesi
Name:lin-49
ORF Names:F42A9.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome IV

Organism-specific databases

WormBaseiF42A9.2; CE07224; WBGene00003034; lin-49.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi325C → S in SA470; reduced activity. 1 Publication1
Mutagenesisi330C → Y in SY238; reduced activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002112051 – 1042Protein lin-49Add BLAST1042

Proteomic databases

EPDiQ20318.
PaxDbiQ20318.
PeptideAtlasiQ20318.

PTM databases

iPTMnetiQ20318.

Expressioni

Tissue specificityi

Widely expressed throughout embryonic development and into adulthood.1 Publication

Developmental stagei

Expressed from mid-blastula.

Gene expression databases

BgeeiWBGene00003034.

Interactioni

Protein-protein interaction databases

STRINGi6239.F42A9.2.1.

Structurei

3D structure databases

ProteinModelPortaliQ20318.
SMRiQ20318.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini523 – 593BromoPROSITE-ProRule annotationAdd BLAST71

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi682 – 762Ser-richAdd BLAST81

Sequence similaritiesi

Contains 1 bromo domain.PROSITE-ProRule annotation
Contains 1 C2HC pre-PHD-type zinc finger.PROSITE-ProRule annotation
Contains 2 PHD-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri195 – 245PHD-type 1PROSITE-ProRule annotationAdd BLAST51
Zinc fingeri249 – 282C2HC pre-PHD-typePROSITE-ProRule annotationAdd BLAST34
Zinc fingeri306 – 366PHD-type 2PROSITE-ProRule annotationAdd BLAST61

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG0955. Eukaryota.
COG5141. LUCA.
GeneTreeiENSGT00740000114866.
HOGENOMiHOG000017181.
InParanoidiQ20318.
KOiK11348.
OMAiDETHFGN.
OrthoDBiEOG091G056P.
PhylomeDBiQ20318.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR019542. Enhancer_polycomb-like_N.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00439. Bromodomain. 1 hit.
PF10513. EPL1. 1 hit.
[Graphical view]
SMARTiSM00297. BROMO. 1 hit.
SM00249. PHD. 2 hits.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51805. EPHD. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q20318-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRGRGVAIQ ETIEECRDTI SDRIQYNLGL NESKVVLMDI VTGPNQNVSL
60 70 80 90 100
QERTKRWMAV SVDARMTKFK KNFYPTNQKN SKNISKDLDP PIQRVDAHIV
110 120 130 140 150
TPVAGKCGMP LQKFPEFKHD HEKIKIERDA KYVDYSVDEF DMSWMSIMNA
160 170 180 190 200
KRTKLGLEIF SVAIYEHWVD RLEKMCIWKP KEFHKLKDEN GEELDDVCNI
210 220 230 240 250
CLDGDTSNCN QIVYCDRCNL SVHQDCYGIP FIPEGCLECR RCGISPAGRV
260 270 280 290 300
NCVLCPSTTG AFKQVDQKRW VHVLCVIWVD ETHFGNTIFM ENVQNVEKAL
310 320 330 340 350
HDRRALSCLL CKNRQNARMG ACIQCSETKC TASFHVTCAR DSGLVMRINE
360 370 380 390 400
TEDGQVNRFV WCPKHAPPLT DADREMRQLM LRNARRENER KGPMISMPTL
410 420 430 440 450
MKSMISTICV ERPFSDYSEI IYFWYEKRLN RLGAPLLKNF TQGASKSRRL
460 470 480 490 500
LPKSTICGQL KNVETCEMKK QVNAVKESLA SGLEIFDMIV RREERKKDML
510 520 530 540 550
NSYIRMFERG FKPTELLCQE VIEALKTIDA GKVFAEPVEL VGYTDIIENP
560 570 580 590 600
ICLKDMSEKA ASGKYSTVAA LSADVQLMLS NCATFNKGNR VYIKYGNTYR
610 620 630 640 650
KDSTPILEIA EKEEVERLAL KTDEKFMTQL LNGVMVEYNG WAQSRNEVAK
660 670 680 690 700
EIPPPTPSRG RGTGRRRQNP FLDVQELDTD DSKDSSALSE IPGSSKKSSR
710 720 730 740 750
KRGIQDTKME EDEEIKPSTS GTNAVASVPL LSSSRESKNK SKSSDADVSS
760 770 780 790 800
PKSSWLGSPS TSQNLRRRVQ GFSGNESSPK VHKKLSTDNP SNSNLRQTTL
810 820 830 840 850
TNFFGTNPKT QQQVTFADMT ATPSGSGNKN VSQRSLFDTP STSKASSFTS
860 870 880 890 900
LSSTRPSTRS TSIIPTINKK NAFRMSSASI QSPLPTTKKI GVRAMATDDE
910 920 930 940 950
EEDIVIQPPP KEMTTQELEA EKLKSAENEA MSKFAHNQLV IVDGRAAKVI
960 970 980 990 1000
ESRLAHLASD IHHEQRQSMM KKRREVLSEI PQAAVIYVEF FQKSNTLENF
1010 1020 1030 1040
QWVTPDKVEL LDLNNIGQRS PKIPGLKAAK EWHQKVLNGE DV
Length:1,042
Mass (Da):117,643
Last modified:November 1, 1996 - v1
Checksum:i8ED000257E202B84
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF163018 mRNA. Translation: AAD49323.1.
FO080904 Genomic DNA. Translation: CCD67656.1.
PIRiT29307.
RefSeqiNP_501475.1. NM_069074.5.
UniGeneiCel.17064.

Genome annotation databases

EnsemblMetazoaiF42A9.2.1; F42A9.2.1; WBGene00003034.
F42A9.2.2; F42A9.2.2; WBGene00003034.
GeneIDi177666.
KEGGicel:CELE_F42A9.2.
UCSCiF42A9.2. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF163018 mRNA. Translation: AAD49323.1.
FO080904 Genomic DNA. Translation: CCD67656.1.
PIRiT29307.
RefSeqiNP_501475.1. NM_069074.5.
UniGeneiCel.17064.

3D structure databases

ProteinModelPortaliQ20318.
SMRiQ20318.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F42A9.2.1.

PTM databases

iPTMnetiQ20318.

Proteomic databases

EPDiQ20318.
PaxDbiQ20318.
PeptideAtlasiQ20318.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF42A9.2.1; F42A9.2.1; WBGene00003034.
F42A9.2.2; F42A9.2.2; WBGene00003034.
GeneIDi177666.
KEGGicel:CELE_F42A9.2.
UCSCiF42A9.2. c. elegans.

Organism-specific databases

CTDi177666.
WormBaseiF42A9.2; CE07224; WBGene00003034; lin-49.

Phylogenomic databases

eggNOGiKOG0955. Eukaryota.
COG5141. LUCA.
GeneTreeiENSGT00740000114866.
HOGENOMiHOG000017181.
InParanoidiQ20318.
KOiK11348.
OMAiDETHFGN.
OrthoDBiEOG091G056P.
PhylomeDBiQ20318.

Miscellaneous databases

PROiQ20318.

Gene expression databases

BgeeiWBGene00003034.

Family and domain databases

Gene3Di1.20.920.10. 1 hit.
3.30.40.10. 1 hit.
InterProiIPR001487. Bromodomain.
IPR018359. Bromodomain_CS.
IPR019542. Enhancer_polycomb-like_N.
IPR019786. Zinc_finger_PHD-type_CS.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00439. Bromodomain. 1 hit.
PF10513. EPL1. 1 hit.
[Graphical view]
SMARTiSM00297. BROMO. 1 hit.
SM00249. PHD. 2 hits.
[Graphical view]
SUPFAMiSSF47370. SSF47370. 1 hit.
SSF57903. SSF57903. 1 hit.
PROSITEiPS00633. BROMODOMAIN_1. 1 hit.
PS50014. BROMODOMAIN_2. 1 hit.
PS51805. EPHD. 1 hit.
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLIN49_CAEEL
AccessioniPrimary (citable) accession number: Q20318
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.