ID   HDA6_CAEEL              Reviewed;         955 AA.
AC   Q20296; Q9BI90; Q9BI91;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   16-MAY-2003, sequence version 2.
DT   16-JUN-2009, entry version 58.
DE   RecName: Full=Histone deacetylase 6;
DE            EC=3.5.1.98;
GN   Name=hda-6; ORFNames=F41H10.6;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea;
OC   Rhabditidae; Peloderinae; Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   MEDLINE=99069613; PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for
RT   investigating biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Probable histone deacetylase. Histone deacetylases are
CC       responsible for the deacetylation of lysine residues on the N-
CC       terminal part of the core histones (H2A, H2B, H3 and H4). Histone
CC       deacetylation gives a tag for epigenetic repression and plays an
CC       important role in transcriptional regulation, cell cycle
CC       progression and developmental events. Histone deacetylases act via
CC       the formation of large multiprotein complexes (By similarity).
CC   -!- CATALYTIC ACTIVITY: Hydrolysis of an N(6)-acetyl-lysine residue of
CC       a histone to yield a deacetylated histone.
CC   -!- SUBCELLULAR LOCATION: Nucleus (Probable).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=b;
CC         IsoId=Q20296-1; Sequence=Displayed;
CC         Note=Derived from EST data. No experimental confirmation
CC         available;
CC       Name=a;
CC         IsoId=Q20296-2; Sequence=VSP_007436, VSP_007437;
CC         Note=Derived from EST data. No experimental confirmation
CC         available;
CC   -!- SIMILARITY: Belongs to the histone deacetylase family. Type 2
CC       subfamily.
CC   -!- SIMILARITY: Contains 1 UBP-type zinc finger.
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DR   EMBL; U61954; AAK29809.1; -; Genomic_DNA.
DR   EMBL; U61954; AAK29810.1; -; Genomic_DNA.
DR   RefSeq; NP_500787.1; -.
DR   UniGene; Cel.12964; -.
DR   PRIDE; Q20296; -.
DR   Ensembl; F41H10.6; Caenorhabditis elegans.
DR   GeneID; 177316; -.
DR   WormBase; WBGene00018319; F41H10.6.
DR   WormPep; F41H10.6a; CE20772.
DR   WormPep; F41H10.6b; CE25887.
DR   OMA; Q20296; QGQGYTI.
DR   NextBio; 896234; -.
DR   ArrayExpress; Q20296; -.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0016568; P:chromatin modification; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR000286; His_deacetylse.
DR   InterPro; IPR001607; Znf_UBP.
DR   Gene3D; G3DSA:3.40.800.20; His_deacetylse; 2.
DR   PANTHER; PTHR10625; His_deacetylse; 1.
DR   Pfam; PF00850; Hist_deacetyl; 2.
DR   Pfam; PF02148; zf-UBP; 1.
DR   PRINTS; PR01270; HDASUPER.
DR   PROSITE; PS50271; ZF_UBP; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Chromatin regulator; Complete proteome;
KW   Hydrolase; Metal-binding; Nucleus; Repeat; Repressor; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN         1    955       Histone deacetylase 6.
FT                                /FTId=PRO_0000114743.
FT   ZN_FING     873    934       UBP-type.
FT   REGION       15    337       Histone deacetylase 1.
FT   REGION      425    749       Histone deacetylase 2.
FT   ACT_SITE    146    146       1 (By similarity).
FT   ACT_SITE    561    561       2 (By similarity).
FT   VAR_SEQ     797    863       VTPSNYGLDIDDEAYDDDSIDMADQSSSSGSSSSSTRPSHN
FT                                LEIMDSGPAHAVVPLATCPHLKEVKP -> IIIGSVLNSKL
FT                                INKNGKSSAATLKVKGKAATDPVKQADDSRRYNTRRRRSAN
FT                                DEVEDVMEKLENMKL (in isoform a).
FT                                /FTId=VSP_007436.
FT   VAR_SEQ     864    955       Missing (in isoform a).
FT                                /FTId=VSP_007437.
SQ   SEQUENCE   955 AA;  106749 MW;  315C314B5ACC9E0E CRC64;
     MLFEDRQKNR STGPTLIGFN QTQNEHENTV CPTHPESSDR ILKIKEALTK TKILEKCTVL
     TNFLEIDDAD LEVTHDKSMV KDLMESEKKT QEDINSQCEK YDSVFMTENS MKVAKDGVAC
     VRDLTNRIMA NEASNGFAVV RPPGHHADSV SPCGFCLFNN VAQAAEEAFF SGAERILIVD
     LDVHHGHGTQ RIFYDDKRVL YFSIHRHEHG LFWPHLPESD FDHIGSGKGL GYNANLALNE
     TGCTDSDYLS IIFHVLLPLA TQFDPHFVII SAGFDALLGD PLGGMCLTPD GYSHILYHLK
     SLAQGRMLVV LEGGYNHQIS AVAVQRCVRV LLGYAPFSIE LNEAPKESTV DSCVSLVSVL
     RHHWNCFDYF PSRTSLRLAQ WPIVNTKVIY NYDPTTRRAD TGEIIQDELA STEFTASDVI
     PTENMETLIY FNEGDDAHFD LEEDNHPEKP ARTRRILKTL RESGVLEKCV DRNCERIATN
     EEIRLVHTKK MLEHLRTTET MKDEELMEEA EKEFNSIYLT RDTLKVARKA VGAVLQSVDE
     IFEKDAGQRN ALVIVRPPGH HASASKSSGF CIFNNVAVAA KYAQRRHKAK RVLILDWDVH
     HGNGTQEIFY EDSNVMYMSI HRHDKGNFYP IGEPKDYSDV GEGAGEGMSV NVPFSGVQMG
     DNEYQMAFQR VIMPIAYQFN PDLVLISAGF DAAVDDPLGE YKVTPETFAL MTYQLSSLAG
     GRIITVLEGG YNLTSISNSA QAVCEVLQNR SMLRRLREEK EQFATKPQKI ESSCIKTIRE
     VCAVQQKYWS ILKGFQVTPS NYGLDIDDEA YDDDSIDMAD QSSSSGSSSS STRPSHNLEI
     MDSGPAHAVV PLATCPHLKE VKPLPPAKIN ARTACSECQI GAEVWTCLTC YKYNCGRFVN
     EHAMMHHLSS SHPMALSMAD LSVWCYPCDS YVHNPALIGA KSAAHESKFG ETMPS
//