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Q20296 (HDA6_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone deacetylase 6

EC=3.5.1.98
Gene names
Name:hda-6
ORF Names:F41H10.6
OrganismCaenorhabditis elegans [Reference proteome]
Taxonomic identifier6239 [NCBI]
Taxonomic lineageEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis

Protein attributes

Sequence length955 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Probable histone deacetylase. Histone deacetylases are responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.

Catalytic activity

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Cofactor

Binds 3 zinc ions per subunit By similarity.

Subcellular location

Nucleus Probable.

Sequence similarities

Belongs to the histone deacetylase family. HD type 2 subfamily.

Contains 1 UBP-type zinc finger.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform b (identifier: Q20296-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Note: Derived from EST data. No experimental confirmation available.
Isoform a (identifier: Q20296-2)

The sequence of this isoform differs from the canonical sequence as follows:
     797-863: VTPSNYGLDI...TCPHLKEVKP → IIIGSVLNSK...VMEKLENMKL
     864-955: Missing.
Note: Derived from EST data. No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 955955Histone deacetylase 6
PRO_0000114743

Regions

Zinc finger873 – 93462UBP-type
Region15 – 337323Histone deacetylase 1
Region425 – 749325Histone deacetylase 2
Region896 – 8983Ubiquitin binding By similarity
Region924 – 9318Ubiquitin binding By similarity

Sites

Active site14611 By similarity
Active site56112 By similarity
Metal binding8551Zinc 1 By similarity
Metal binding8571Zinc 1 By similarity
Metal binding8751Zinc 3 By similarity
Metal binding8781Zinc 3 By similarity
Metal binding8871Zinc 2 By similarity
Metal binding8901Zinc 2 By similarity
Metal binding8951Zinc 3 By similarity
Metal binding9021Zinc 3 By similarity
Metal binding9061Zinc 2 By similarity
Metal binding9121Zinc 2 By similarity
Metal binding9251Zinc 1 By similarity
Metal binding9281Zinc 1 By similarity

Natural variations

Alternative sequence797 – 86367VTPSN…KEVKP → IIIGSVLNSKLINKNGKSSA ATLKVKGKAATDPVKQADDS RRYNTRRRRSANDEVEDVME KLENMKL in isoform a.
VSP_007436
Alternative sequence864 – 95592Missing in isoform a.
VSP_007437

Sequences

Sequence LengthMass (Da)Tools
Isoform b [UniParc].

Last modified May 16, 2003. Version 2.
Checksum: 315C314B5ACC9E0E

FASTA955106,749
        10         20         30         40         50         60 
MLFEDRQKNR STGPTLIGFN QTQNEHENTV CPTHPESSDR ILKIKEALTK TKILEKCTVL 

        70         80         90        100        110        120 
TNFLEIDDAD LEVTHDKSMV KDLMESEKKT QEDINSQCEK YDSVFMTENS MKVAKDGVAC 

       130        140        150        160        170        180 
VRDLTNRIMA NEASNGFAVV RPPGHHADSV SPCGFCLFNN VAQAAEEAFF SGAERILIVD 

       190        200        210        220        230        240 
LDVHHGHGTQ RIFYDDKRVL YFSIHRHEHG LFWPHLPESD FDHIGSGKGL GYNANLALNE 

       250        260        270        280        290        300 
TGCTDSDYLS IIFHVLLPLA TQFDPHFVII SAGFDALLGD PLGGMCLTPD GYSHILYHLK 

       310        320        330        340        350        360 
SLAQGRMLVV LEGGYNHQIS AVAVQRCVRV LLGYAPFSIE LNEAPKESTV DSCVSLVSVL 

       370        380        390        400        410        420 
RHHWNCFDYF PSRTSLRLAQ WPIVNTKVIY NYDPTTRRAD TGEIIQDELA STEFTASDVI 

       430        440        450        460        470        480 
PTENMETLIY FNEGDDAHFD LEEDNHPEKP ARTRRILKTL RESGVLEKCV DRNCERIATN 

       490        500        510        520        530        540 
EEIRLVHTKK MLEHLRTTET MKDEELMEEA EKEFNSIYLT RDTLKVARKA VGAVLQSVDE 

       550        560        570        580        590        600 
IFEKDAGQRN ALVIVRPPGH HASASKSSGF CIFNNVAVAA KYAQRRHKAK RVLILDWDVH 

       610        620        630        640        650        660 
HGNGTQEIFY EDSNVMYMSI HRHDKGNFYP IGEPKDYSDV GEGAGEGMSV NVPFSGVQMG 

       670        680        690        700        710        720 
DNEYQMAFQR VIMPIAYQFN PDLVLISAGF DAAVDDPLGE YKVTPETFAL MTYQLSSLAG 

       730        740        750        760        770        780 
GRIITVLEGG YNLTSISNSA QAVCEVLQNR SMLRRLREEK EQFATKPQKI ESSCIKTIRE 

       790        800        810        820        830        840 
VCAVQQKYWS ILKGFQVTPS NYGLDIDDEA YDDDSIDMAD QSSSSGSSSS STRPSHNLEI 

       850        860        870        880        890        900 
MDSGPAHAVV PLATCPHLKE VKPLPPAKIN ARTACSECQI GAEVWTCLTC YKYNCGRFVN 

       910        920        930        940        950 
EHAMMHHLSS SHPMALSMAD LSVWCYPCDS YVHNPALIGA KSAAHESKFG ETMPS 

« Hide

Isoform a [UniParc].

Checksum: F36CAF4F3DC93AB7
Show »

FASTA86397,087

References

[1]"Genome sequence of the nematode C. elegans: a platform for investigating biology."
The C. elegans sequencing consortium
Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Bristol N2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
FO081367 Genomic DNA. Translation: CCD71098.1.
FO081367 Genomic DNA. Translation: CCD71099.1.
RefSeqNP_500787.1. NM_068386.3.
NP_500788.1. NM_068387.3.
UniGeneCel.12964.

3D structure databases

ProteinModelPortalQ20296.
SMRQ20296. Positions 34-367, 442-793, 851-954.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PaxDbQ20296.
PRIDEQ20296.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaF41H10.6b; F41H10.6b; F41H10.6. [Q20296-1]
GeneID177316.
KEGGcel:CELE_F41H10.6.
UCSCY51H1A.5.1. c. elegans. [Q20296-1]

Organism-specific databases

CTD177316.
WormBaseF41H10.6a; CE20772; WBGene00018319; hda-6.
F41H10.6b; CE25887; WBGene00018319; hda-6.

Phylogenomic databases

eggNOGCOG0123.
HOGENOMHOG000004769.
KOK11407.

Family and domain databases

Gene3D3.30.40.10. 1 hit.
3.40.800.20. 2 hits.
InterProIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view]
PANTHERPTHR10625. PTHR10625. 1 hit.
PfamPF00850. Hist_deacetyl. 2 hits.
PF02148. zf-UBP. 1 hit.
[Graphical view]
PRINTSPR01270. HDASUPER.
PROSITEPS50271. ZF_UBP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio896234.
PROQ20296.

Entry information

Entry nameHDA6_CAEEL
AccessionPrimary (citable) accession number: Q20296
Secondary accession number(s): Q9BI90, Q9BI91
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 16, 2003
Last modified: April 16, 2014
This is version 99 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Relevant documents

SIMILARITY comments

Index of protein domains and families

Caenorhabditis elegans

Caenorhabditis elegans: entries, gene names and cross-references to WormBase