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Q20296

- HDA6_CAEEL

UniProt

Q20296 - HDA6_CAEEL

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Protein
Histone deacetylase 6
Gene
hda-6, F41H10.6
Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Probable histone deacetylase. Histone deacetylases are responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity.

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Cofactori

Binds 3 zinc ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei146 – 14611 By similarity
Active sitei561 – 56112 By similarity
Metal bindingi855 – 8551Zinc 1 By similarity
Metal bindingi857 – 8571Zinc 1 By similarity
Metal bindingi875 – 8751Zinc 3 By similarity
Metal bindingi878 – 8781Zinc 3 By similarity
Metal bindingi887 – 8871Zinc 2 By similarity
Metal bindingi890 – 8901Zinc 2 By similarity
Metal bindingi895 – 8951Zinc 3 By similarity
Metal bindingi902 – 9021Zinc 3 By similarity
Metal bindingi906 – 9061Zinc 2 By similarity
Metal bindingi912 – 9121Zinc 2 By similarity
Metal bindingi925 – 9251Zinc 1 By similarity
Metal bindingi928 – 9281Zinc 1 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri873 – 93462UBP-type
Add
BLAST

GO - Molecular functioni

  1. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  2. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  3. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  4. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC
  5. protein deacetylase activity Source: WormBase
  6. zinc ion binding Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. protein deacetylation Source: GOC
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase 6 (EC:3.5.1.98)
Gene namesi
Name:hda-6
ORF Names:F41H10.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome IV

Organism-specific databases

WormBaseiF41H10.6a; CE20772; WBGene00018319; hda-6.
F41H10.6b; CE25887; WBGene00018319; hda-6.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 955955Histone deacetylase 6
PRO_0000114743Add
BLAST

Proteomic databases

PaxDbiQ20296.
PRIDEiQ20296.

Structurei

3D structure databases

ProteinModelPortaliQ20296.
SMRiQ20296. Positions 34-393, 442-816, 851-954.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni15 – 337323Histone deacetylase 1
Add
BLAST
Regioni425 – 749325Histone deacetylase 2
Add
BLAST
Regioni896 – 8983Ubiquitin binding By similarity
Regioni924 – 9318Ubiquitin binding By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG0123.
GeneTreeiENSGT00530000062809.
HOGENOMiHOG000004769.
KOiK11407.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
3.40.800.20. 2 hits.
InterProiIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 2 hits.
PF02148. zf-UBP. 1 hit.
[Graphical view]
PRINTSiPR01270. HDASUPER.
PROSITEiPS50271. ZF_UBP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform b (identifier: Q20296-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MLFEDRQKNR STGPTLIGFN QTQNEHENTV CPTHPESSDR ILKIKEALTK    50
TKILEKCTVL TNFLEIDDAD LEVTHDKSMV KDLMESEKKT QEDINSQCEK 100
YDSVFMTENS MKVAKDGVAC VRDLTNRIMA NEASNGFAVV RPPGHHADSV 150
SPCGFCLFNN VAQAAEEAFF SGAERILIVD LDVHHGHGTQ RIFYDDKRVL 200
YFSIHRHEHG LFWPHLPESD FDHIGSGKGL GYNANLALNE TGCTDSDYLS 250
IIFHVLLPLA TQFDPHFVII SAGFDALLGD PLGGMCLTPD GYSHILYHLK 300
SLAQGRMLVV LEGGYNHQIS AVAVQRCVRV LLGYAPFSIE LNEAPKESTV 350
DSCVSLVSVL RHHWNCFDYF PSRTSLRLAQ WPIVNTKVIY NYDPTTRRAD 400
TGEIIQDELA STEFTASDVI PTENMETLIY FNEGDDAHFD LEEDNHPEKP 450
ARTRRILKTL RESGVLEKCV DRNCERIATN EEIRLVHTKK MLEHLRTTET 500
MKDEELMEEA EKEFNSIYLT RDTLKVARKA VGAVLQSVDE IFEKDAGQRN 550
ALVIVRPPGH HASASKSSGF CIFNNVAVAA KYAQRRHKAK RVLILDWDVH 600
HGNGTQEIFY EDSNVMYMSI HRHDKGNFYP IGEPKDYSDV GEGAGEGMSV 650
NVPFSGVQMG DNEYQMAFQR VIMPIAYQFN PDLVLISAGF DAAVDDPLGE 700
YKVTPETFAL MTYQLSSLAG GRIITVLEGG YNLTSISNSA QAVCEVLQNR 750
SMLRRLREEK EQFATKPQKI ESSCIKTIRE VCAVQQKYWS ILKGFQVTPS 800
NYGLDIDDEA YDDDSIDMAD QSSSSGSSSS STRPSHNLEI MDSGPAHAVV 850
PLATCPHLKE VKPLPPAKIN ARTACSECQI GAEVWTCLTC YKYNCGRFVN 900
EHAMMHHLSS SHPMALSMAD LSVWCYPCDS YVHNPALIGA KSAAHESKFG 950
ETMPS 955

Note: Derived from EST data. No experimental confirmation available.

Length:955
Mass (Da):106,749
Last modified:May 16, 2003 - v2
Checksum:i315C314B5ACC9E0E
GO
Isoform a (identifier: Q20296-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     797-863: VTPSNYGLDI...TCPHLKEVKP → IIIGSVLNSK...VMEKLENMKL
     864-955: Missing.

Note: Derived from EST data. No experimental confirmation available.

Show »
Length:863
Mass (Da):97,087
Checksum:iF36CAF4F3DC93AB7
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei797 – 86367VTPSN…KEVKP → IIIGSVLNSKLINKNGKSSA ATLKVKGKAATDPVKQADDS RRYNTRRRRSANDEVEDVME KLENMKL in isoform a.
VSP_007436Add
BLAST
Alternative sequencei864 – 95592Missing in isoform a.
VSP_007437Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO081367 Genomic DNA. Translation: CCD71098.1.
FO081367 Genomic DNA. Translation: CCD71099.1.
RefSeqiNP_500787.1. NM_068386.3. [Q20296-1]
NP_500788.1. NM_068387.3. [Q20296-2]
UniGeneiCel.12964.

Genome annotation databases

EnsemblMetazoaiF41H10.6b; F41H10.6b; WBGene00018319. [Q20296-1]
GeneIDi177316.
KEGGicel:CELE_F41H10.6.
UCSCiY51H1A.5.1. c. elegans. [Q20296-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO081367 Genomic DNA. Translation: CCD71098.1 .
FO081367 Genomic DNA. Translation: CCD71099.1 .
RefSeqi NP_500787.1. NM_068386.3. [Q20296-1 ]
NP_500788.1. NM_068387.3. [Q20296-2 ]
UniGenei Cel.12964.

3D structure databases

ProteinModelPortali Q20296.
SMRi Q20296. Positions 34-393, 442-816, 851-954.
ModBasei Search...

Proteomic databases

PaxDbi Q20296.
PRIDEi Q20296.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai F41H10.6b ; F41H10.6b ; WBGene00018319 . [Q20296-1 ]
GeneIDi 177316.
KEGGi cel:CELE_F41H10.6.
UCSCi Y51H1A.5.1. c. elegans. [Q20296-1 ]

Organism-specific databases

CTDi 177316.
WormBasei F41H10.6a ; CE20772 ; WBGene00018319 ; hda-6.
F41H10.6b ; CE25887 ; WBGene00018319 ; hda-6.

Phylogenomic databases

eggNOGi COG0123.
GeneTreei ENSGT00530000062809.
HOGENOMi HOG000004769.
KOi K11407.

Miscellaneous databases

NextBioi 896234.
PROi Q20296.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
3.40.800.20. 2 hits.
InterProi IPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF00850. Hist_deacetyl. 2 hits.
PF02148. zf-UBP. 1 hit.
[Graphical view ]
PRINTSi PR01270. HDASUPER.
PROSITEi PS50271. ZF_UBP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiHDA6_CAEEL
AccessioniPrimary (citable) accession number: Q20296
Secondary accession number(s): Q9BI90, Q9BI91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 16, 2003
Last modified: June 11, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi