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Q20296

- HDA6_CAEEL

UniProt

Q20296 - HDA6_CAEEL

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Protein

Histone deacetylase 6

Gene

hda-6

Organism
Caenorhabditis elegans
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Probable histone deacetylase. Histone deacetylases are responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes (By similarity).By similarity

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Cofactori

Binds 3 zinc ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei146 – 14611By similarity
Active sitei561 – 56112By similarity
Metal bindingi855 – 8551Zinc 1By similarity
Metal bindingi857 – 8571Zinc 1By similarity
Metal bindingi875 – 8751Zinc 3By similarity
Metal bindingi878 – 8781Zinc 3By similarity
Metal bindingi887 – 8871Zinc 2By similarity
Metal bindingi890 – 8901Zinc 2By similarity
Metal bindingi895 – 8951Zinc 3By similarity
Metal bindingi902 – 9021Zinc 3By similarity
Metal bindingi906 – 9061Zinc 2By similarity
Metal bindingi912 – 9121Zinc 2By similarity
Metal bindingi925 – 9251Zinc 1By similarity
Metal bindingi928 – 9281Zinc 1By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri873 – 93462UBP-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  2. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  3. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  4. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC
  5. protein deacetylase activity Source: WormBase
  6. zinc ion binding Source: InterPro

GO - Biological processi

  1. protein deacetylation Source: GOC
  2. regulation of transcription, DNA-templated Source: UniProtKB-KW
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Hydrolase, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylase 6 (EC:3.5.1.98)
Gene namesi
Name:hda-6
ORF Names:F41H10.6
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
ProteomesiUP000001940: Chromosome IV

Organism-specific databases

WormBaseiF41H10.6a; CE20772; WBGene00018319; hda-6.
F41H10.6b; CE25887; WBGene00018319; hda-6.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 955955Histone deacetylase 6PRO_0000114743Add
BLAST

Proteomic databases

PaxDbiQ20296.
PRIDEiQ20296.

Expressioni

Gene expression databases

ExpressionAtlasiQ20296. baseline.

Structurei

3D structure databases

ProteinModelPortaliQ20296.
SMRiQ20296. Positions 34-393, 442-816, 851-954.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni15 – 337323Histone deacetylase 1Add
BLAST
Regioni425 – 749325Histone deacetylase 2Add
BLAST
Regioni896 – 8983Ubiquitin bindingBy similarity
Regioni924 – 9318Ubiquitin bindingBy similarity

Sequence similaritiesi

Contains 1 UBP-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri873 – 93462UBP-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG0123.
GeneTreeiENSGT00530000062809.
HOGENOMiHOG000004769.
InParanoidiQ20296.
KOiK11407.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
3.40.800.20. 2 hits.
InterProiIPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 2 hits.
PF02148. zf-UBP. 1 hit.
[Graphical view]
PRINTSiPR01270. HDASUPER.
PROSITEiPS50271. ZF_UBP. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform b (identifier: Q20296-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLFEDRQKNR STGPTLIGFN QTQNEHENTV CPTHPESSDR ILKIKEALTK
60 70 80 90 100
TKILEKCTVL TNFLEIDDAD LEVTHDKSMV KDLMESEKKT QEDINSQCEK
110 120 130 140 150
YDSVFMTENS MKVAKDGVAC VRDLTNRIMA NEASNGFAVV RPPGHHADSV
160 170 180 190 200
SPCGFCLFNN VAQAAEEAFF SGAERILIVD LDVHHGHGTQ RIFYDDKRVL
210 220 230 240 250
YFSIHRHEHG LFWPHLPESD FDHIGSGKGL GYNANLALNE TGCTDSDYLS
260 270 280 290 300
IIFHVLLPLA TQFDPHFVII SAGFDALLGD PLGGMCLTPD GYSHILYHLK
310 320 330 340 350
SLAQGRMLVV LEGGYNHQIS AVAVQRCVRV LLGYAPFSIE LNEAPKESTV
360 370 380 390 400
DSCVSLVSVL RHHWNCFDYF PSRTSLRLAQ WPIVNTKVIY NYDPTTRRAD
410 420 430 440 450
TGEIIQDELA STEFTASDVI PTENMETLIY FNEGDDAHFD LEEDNHPEKP
460 470 480 490 500
ARTRRILKTL RESGVLEKCV DRNCERIATN EEIRLVHTKK MLEHLRTTET
510 520 530 540 550
MKDEELMEEA EKEFNSIYLT RDTLKVARKA VGAVLQSVDE IFEKDAGQRN
560 570 580 590 600
ALVIVRPPGH HASASKSSGF CIFNNVAVAA KYAQRRHKAK RVLILDWDVH
610 620 630 640 650
HGNGTQEIFY EDSNVMYMSI HRHDKGNFYP IGEPKDYSDV GEGAGEGMSV
660 670 680 690 700
NVPFSGVQMG DNEYQMAFQR VIMPIAYQFN PDLVLISAGF DAAVDDPLGE
710 720 730 740 750
YKVTPETFAL MTYQLSSLAG GRIITVLEGG YNLTSISNSA QAVCEVLQNR
760 770 780 790 800
SMLRRLREEK EQFATKPQKI ESSCIKTIRE VCAVQQKYWS ILKGFQVTPS
810 820 830 840 850
NYGLDIDDEA YDDDSIDMAD QSSSSGSSSS STRPSHNLEI MDSGPAHAVV
860 870 880 890 900
PLATCPHLKE VKPLPPAKIN ARTACSECQI GAEVWTCLTC YKYNCGRFVN
910 920 930 940 950
EHAMMHHLSS SHPMALSMAD LSVWCYPCDS YVHNPALIGA KSAAHESKFG

ETMPS

Note: Derived from EST data. No experimental confirmation available.

Length:955
Mass (Da):106,749
Last modified:May 16, 2003 - v2
Checksum:i315C314B5ACC9E0E
GO
Isoform a (identifier: Q20296-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     797-863: VTPSNYGLDI...TCPHLKEVKP → IIIGSVLNSK...VMEKLENMKL
     864-955: Missing.

Note: Derived from EST data. No experimental confirmation available.

Show »
Length:863
Mass (Da):97,087
Checksum:iF36CAF4F3DC93AB7
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei797 – 86367VTPSN…KEVKP → IIIGSVLNSKLINKNGKSSA ATLKVKGKAATDPVKQADDS RRYNTRRRRSANDEVEDVME KLENMKL in isoform a. CuratedVSP_007436Add
BLAST
Alternative sequencei864 – 95592Missing in isoform a. CuratedVSP_007437Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO081367 Genomic DNA. Translation: CCD71098.1.
FO081367 Genomic DNA. Translation: CCD71099.1.
RefSeqiNP_500787.1. NM_068386.3. [Q20296-1]
NP_500788.1. NM_068387.3. [Q20296-2]
UniGeneiCel.12964.

Genome annotation databases

EnsemblMetazoaiF41H10.6b; F41H10.6b; WBGene00018319. [Q20296-1]
GeneIDi177316.
KEGGicel:CELE_F41H10.6.
UCSCiY51H1A.5.1. c. elegans. [Q20296-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
FO081367 Genomic DNA. Translation: CCD71098.1 .
FO081367 Genomic DNA. Translation: CCD71099.1 .
RefSeqi NP_500787.1. NM_068386.3. [Q20296-1 ]
NP_500788.1. NM_068387.3. [Q20296-2 ]
UniGenei Cel.12964.

3D structure databases

ProteinModelPortali Q20296.
SMRi Q20296. Positions 34-393, 442-816, 851-954.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q20296.
PRIDEi Q20296.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblMetazoai F41H10.6b ; F41H10.6b ; WBGene00018319 . [Q20296-1 ]
GeneIDi 177316.
KEGGi cel:CELE_F41H10.6.
UCSCi Y51H1A.5.1. c. elegans. [Q20296-1 ]

Organism-specific databases

CTDi 177316.
WormBasei F41H10.6a ; CE20772 ; WBGene00018319 ; hda-6.
F41H10.6b ; CE25887 ; WBGene00018319 ; hda-6.

Phylogenomic databases

eggNOGi COG0123.
GeneTreei ENSGT00530000062809.
HOGENOMi HOG000004769.
InParanoidi Q20296.
KOi K11407.

Miscellaneous databases

NextBioi 896234.
PROi Q20296.

Gene expression databases

ExpressionAtlasi Q20296. baseline.

Family and domain databases

Gene3Di 3.30.40.10. 1 hit.
3.40.800.20. 2 hits.
InterProi IPR000286. His_deacetylse.
IPR023801. His_deacetylse_dom.
IPR013083. Znf_RING/FYVE/PHD.
IPR001607. Znf_UBP.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF00850. Hist_deacetyl. 2 hits.
PF02148. zf-UBP. 1 hit.
[Graphical view ]
PRINTSi PR01270. HDASUPER.
PROSITEi PS50271. ZF_UBP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiHDA6_CAEEL
AccessioniPrimary (citable) accession number: Q20296
Secondary accession number(s): Q9BI90, Q9BI91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 16, 2003
Last modified: October 29, 2014
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3