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Protein

Calsequestrin

Gene

csq-1

Organism
Caenorhabditis elegans
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.UniRule annotation

GO - Molecular functioni

  • calcium ion binding Source: WormBase

GO - Biological processi

  • calcium ion homeostasis Source: WormBase
Complete GO annotation...

Keywords - Ligandi

CalciumUniRule annotation

Enzyme and pathway databases

ReactomeiR-CEL-2672351. Stimuli-sensing channels.
R-CEL-5578775. Ion homeostasis.

Names & Taxonomyi

Protein namesi
Recommended name:
CalsequestrinUniRule annotation
Gene namesi
Name:csq-1Imported
ORF Names:CELE_F40E10.3Imported, F40E10.3Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiF40E10.3; CE05839; WBGene00000822; csq-1.

Subcellular locationi

GO - Cellular componenti

  • apical plasma membrane Source: WormBase
  • cytoplasm Source: WormBase
  • nucleus Source: WormBase
  • sarcolemma Source: WormBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Chaini19 – 417399CalsequestrinSequence analysisPRO_5004199248Add
BLAST

Proteomic databases

EPDiQ20203.
PaxDbiQ20203.

Interactioni

Protein-protein interaction databases

IntActiQ20203. 1 interaction.
STRINGi6239.F40E10.3.2.

Structurei

3D structure databases

ProteinModelPortaliQ20203.
SMRiQ20203. Positions 37-365.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the calsequestrin family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiENOG410IGY5. Eukaryota.
ENOG4111R2M. LUCA.
GeneTreeiENSGT00390000019377.
HOGENOMiHOG000018341.
InParanoidiQ20203.
OMAiVYVFKGD.
PhylomeDBiQ20203.

Family and domain databases

Gene3Di3.40.30.10. 3 hits.
InterProiIPR001393. Calsequestrin.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF01216. Calsequestrin. 1 hit.
[Graphical view]
PRINTSiPR00312. CALSEQUESTRN.
SUPFAMiSSF52833. SSF52833. 3 hits.

Sequencei

Sequence statusi: Complete.

Q20203-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTWIKLASLA LVVVLASAGI SKNEDLECMF LGYPDLEYDG FDRTEVLTEK
60 70 80 90 100
NFNRTVFAED TKSVVFFNDV EEDDSELDQY ECFLQLSAQI MTKRGYNFYT
110 120 130 140 150
VNTTKEHRLR KQEEVEKGED TIHVYKDGYK IEYNGVRDPE TFVSWLMDIP
160 170 180 190 200
DDPVTIINDE HDLEEFENMD DECVRIIGYF EPGSVALKEF EEAAEDFMGE
210 220 230 240 250
IEFFAVVTSK WARKVGLKRV GEVQMRRPFE EDPLFAPTSA DTEEEFEDWV
260 270 280 290 300
EKNKEPVMQK LTLDNYFNLW RDPEEEERMI LAFVDEETRE GRAMKRLLDK
310 320 330 340 350
IADENSEHAG TLEIILVDPD EFPLMVDVWE DMFGIDIEEG PQIGLIDISE
360 370 380 390 400
KEGIWFDMSQ VNLDDPKKHS DSNFEALQSW IDQILSGSIS LDDDDDDEPE
410
PPAPPPTPKG KKSRKEL
Length:417
Mass (Da):48,327
Last modified:November 1, 1996 - v1
Checksum:i02B52D4CDBC92BA1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA. Translation: CAA93667.1.
PIRiT22024.
RefSeqiNP_510438.1. NM_078037.4.
UniGeneiCel.5077.

Genome annotation databases

EnsemblMetazoaiF40E10.3; F40E10.3; WBGene00000822.
GeneIDi181563.
KEGGicel:CELE_F40E10.3.
UCSCiF40E10.3.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284606 Genomic DNA. Translation: CAA93667.1.
PIRiT22024.
RefSeqiNP_510438.1. NM_078037.4.
UniGeneiCel.5077.

3D structure databases

ProteinModelPortaliQ20203.
SMRiQ20203. Positions 37-365.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ20203. 1 interaction.
STRINGi6239.F40E10.3.2.

Proteomic databases

EPDiQ20203.
PaxDbiQ20203.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF40E10.3; F40E10.3; WBGene00000822.
GeneIDi181563.
KEGGicel:CELE_F40E10.3.
UCSCiF40E10.3.1. c. elegans.

Organism-specific databases

CTDi181563.
WormBaseiF40E10.3; CE05839; WBGene00000822; csq-1.

Phylogenomic databases

eggNOGiENOG410IGY5. Eukaryota.
ENOG4111R2M. LUCA.
GeneTreeiENSGT00390000019377.
HOGENOMiHOG000018341.
InParanoidiQ20203.
OMAiVYVFKGD.
PhylomeDBiQ20203.

Enzyme and pathway databases

ReactomeiR-CEL-2672351. Stimuli-sensing channels.
R-CEL-5578775. Ion homeostasis.

Family and domain databases

Gene3Di3.40.30.10. 3 hits.
InterProiIPR001393. Calsequestrin.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF01216. Calsequestrin. 1 hit.
[Graphical view]
PRINTSiPR00312. CALSEQUESTRN.
SUPFAMiSSF52833. SSF52833. 3 hits.
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    Caenorhabditis elegans Sequencing Consortium
    Sulson J.E., Waterston R.
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2Imported.

Entry informationi

Entry nameiQ20203_CAEEL
AccessioniPrimary (citable) accession number: Q20203
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: June 8, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.