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Protein

Adenylate kinase isoenzyme 1

Gene

F38B2.4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.UniRule annotation

Catalytic activityi

ATP + AMP = 2 ADP.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei51AMPUniRule annotation1
Binding sitei56AMPUniRule annotation1
Binding sitei114AMPUniRule annotation1
Binding sitei145ATPUniRule annotation1
Binding sitei151AMPUniRule annotation1
Binding sitei162AMPUniRule annotation1
Binding sitei190ATP; via carbonyl oxygenUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi30 – 35ATPUniRule annotation6
Nucleotide bindingi77 – 79AMPUniRule annotation3
Nucleotide bindingi107 – 110AMPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.4.3. 1045.
ReactomeiR-CEL-499943. Synthesis and interconversion of nucleotide di- and triphosphates.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate kinase isoenzyme 1UniRule annotation (EC:2.7.4.3UniRule annotation)
Short name:
AK 1UniRule annotation
Alternative name(s):
ATP-AMP transphosphorylase 1UniRule annotation
ATP:AMP phosphotransferaseUniRule annotation
Adenylate monophosphate kinaseUniRule annotation
Gene namesi
ORF Names:F38B2.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiF38B2.4a; CE02218; WBGene00009531.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001589321 – 210Adenylate kinase isoenzyme 1Add BLAST210

Proteomic databases

EPDiQ20140.
PaxDbiQ20140.
PeptideAtlasiQ20140.
PRIDEiQ20140.

Expressioni

Gene expression databases

BgeeiWBGene00009531.

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi6239.F38B2.4a.

Structurei

3D structure databases

ProteinModelPortaliQ20140.
SMRiQ20140.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni50 – 79NMPbindUniRule annotationAdd BLAST30
Regioni144 – 154LIDUniRule annotationAdd BLAST11

Domaini

Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.UniRule annotation

Sequence similaritiesi

Belongs to the adenylate kinase family. AK1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG3079. Eukaryota.
COG0563. LUCA.
GeneTreeiENSGT00390000016215.
HOGENOMiHOG000238771.
InParanoidiQ20140.
KOiK00939.
OMAiPREKNQG.
OrthoDBiEOG091G0OQ7.
PhylomeDBiQ20140.

Family and domain databases

CDDicd01428. ADK. 1 hit.
Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00235. Adenylate_kinase_Adk. 1 hit.
MF_03171. Adenylate_kinase_AK1. 1 hit.
InterProiIPR000850. Adenylat/UMP-CMP_kin.
IPR033690. Adenylat_kinase_CS.
IPR028582. AK1.
IPR006267. AK1/5.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR23359. PTHR23359. 1 hit.
PRINTSiPR00094. ADENYLTKNASE.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01360. aden_kin_iso1. 1 hit.
PROSITEiPS00113. ADENYLATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q20140-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPTVERKNI NLAPLKAAGV PIFFIVGGPG SGKGTQCDKI VAKYGLTHLS
60 70 80 90 100
SGDLLRDEVK SGSPRGAQLT AIMESGALVP LEVVLDLVKE AMLKAIEKGS
110 120 130 140 150
KGFLIDGYPR EVAQGQQFES EIQEAKLVLF FDVAEETLVK RLLHRAQTSG
160 170 180 190 200
RADDNADTIK KRLHTFVTST APVVDYYESK GKLVRINAEG SVDDIFAVVV
210
ANLDKATSKL
Length:210
Mass (Da):22,597
Last modified:November 1, 1996 - v1
Checksum:i786CB879D83DDFFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z50045 Genomic DNA. Translation: CAA90364.1.
AF304123 mRNA. Translation: AAG50236.1.
PIRiT21947.
RefSeqiNP_001257141.1. NM_001270212.1.
UniGeneiCel.7837.

Genome annotation databases

EnsemblMetazoaiF38B2.4a; F38B2.4a; WBGene00009531.
GeneIDi181317.
KEGGicel:CELE_F38B2.4.
UCSCiF38B2.4. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z50045 Genomic DNA. Translation: CAA90364.1.
AF304123 mRNA. Translation: AAG50236.1.
PIRiT21947.
RefSeqiNP_001257141.1. NM_001270212.1.
UniGeneiCel.7837.

3D structure databases

ProteinModelPortaliQ20140.
SMRiQ20140.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F38B2.4a.

Proteomic databases

EPDiQ20140.
PaxDbiQ20140.
PeptideAtlasiQ20140.
PRIDEiQ20140.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF38B2.4a; F38B2.4a; WBGene00009531.
GeneIDi181317.
KEGGicel:CELE_F38B2.4.
UCSCiF38B2.4. c. elegans.

Organism-specific databases

CTDi181317.
WormBaseiF38B2.4a; CE02218; WBGene00009531.

Phylogenomic databases

eggNOGiKOG3079. Eukaryota.
COG0563. LUCA.
GeneTreeiENSGT00390000016215.
HOGENOMiHOG000238771.
InParanoidiQ20140.
KOiK00939.
OMAiPREKNQG.
OrthoDBiEOG091G0OQ7.
PhylomeDBiQ20140.

Enzyme and pathway databases

BRENDAi2.7.4.3. 1045.
ReactomeiR-CEL-499943. Synthesis and interconversion of nucleotide di- and triphosphates.

Miscellaneous databases

PROiQ20140.

Gene expression databases

BgeeiWBGene00009531.

Family and domain databases

CDDicd01428. ADK. 1 hit.
Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00235. Adenylate_kinase_Adk. 1 hit.
MF_03171. Adenylate_kinase_AK1. 1 hit.
InterProiIPR000850. Adenylat/UMP-CMP_kin.
IPR033690. Adenylat_kinase_CS.
IPR028582. AK1.
IPR006267. AK1/5.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR23359. PTHR23359. 1 hit.
PRINTSiPR00094. ADENYLTKNASE.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01360. aden_kin_iso1. 1 hit.
PROSITEiPS00113. ADENYLATE_KINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKAD1_CAEEL
AccessioniPrimary (citable) accession number: Q20140
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.