Q20140 (KAD1_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable adenylate kinase isoenzyme F38B2.4
Short name=AK
EC=2.7.4.3

Alternative name(s):
ATP-AMP transphosphorylase

Gene names

ORF Names:

F38B2.4

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	210 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth By similarity.
Catalytic activity	ATP + AMP = 2 ADP.
Subunit structure	Monomer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the adenylate kinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	ATP metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW adenylate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 210	210	Probable adenylate kinase isoenzyme F38B2.4		PRO_0000158932
Regions
	Nucleotide binding	27 – 35	9	ATP
	Nucleotide binding	107 – 114	8	AMP By similarity
Sites
	Binding site	51	1	AMP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q20140 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 786CB879D83DDFFC	FASTA	210	22,597
	10 20 30 40 50 60 MAPTVERKNI NLAPLKAAGV PIFFIVGGPG SGKGTQCDKI VAKYGLTHLS SGDLLRDEVK 70 80 90 100 110 120 SGSPRGAQLT AIMESGALVP LEVVLDLVKE AMLKAIEKGS KGFLIDGYPR EVAQGQQFES 130 140 150 160 170 180 EIQEAKLVLF FDVAEETLVK RLLHRAQTSG RADDNADTIK KRLHTFVTST APVVDYYESK 190 200 210 GKLVRINAEG SVDDIFAVVV ANLDKATSKL

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
[2]	"The Caenorhabditis elegans transcriptome project, a complementary view of the genome." Kohara Y., Shin-i T., Suzuki Y., Sugano S., Potdevin M., Thierry-Mieg Y., Thierry-Mieg D., Thierry-Mieg J. Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z50045 Genomic DNA. Translation: CAA90364.1. AF304123 mRNA. Translation: AAG50236.1.
PIR	T21947.
RefSeq	NP_509884.1. NM_077483.4.
UniGene	Cel.7837.
3D structure databases
ProteinModelPortal	Q20140.
SMR	Q20140. Positions 22-204.
ModBase	Search...
Protein-protein interaction databases
STRING	Q20140.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	F38B2.4a; F38B2.4a; F38B2.4.
GeneID	181317.
KEGG	cel:F38B2.4.
UCSC	F38B2.4. c. elegans.
Organism-specific databases
CTD	181317.
WormBase	F38B2.4a; CE02218; WBGene00009531.
Phylogenomic databases
eggNOG	meNOG07915.
GeneTree	EMGT00050000010442.
HOGENOM	HBG630208.
InParanoid	Q20140.
OMA	HEIASGS.
PhylomeDB	Q20140.
Gene expression databases
ArrayExpress	Q20140.
Family and domain databases
InterPro	IPR000850. Adenylate_kin. IPR006267. Adenylate_kin1. [Graphical view]
KO	K00939.
PANTHER	PTHR23359. Adenylate_kin. 1 hit.
Pfam	PF00406. ADK. 1 hit. [Graphical view]
PRINTS	PR00094. ADENYLTKNASE.
TIGRFAMs	TIGR01360. Aden_kin_iso1. 1 hit.
PROSITE	PS00113. ADENYLATE_KINASE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	913424.

Entry information

Entry name

KAD1_CAEEL

Accession

Primary (citable) accession number: Q20140

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2002
Last sequence update:	November 1, 1996
Last modified:	November 16, 2011
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project