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Protein

Adenylate kinase isoenzyme 1

Gene

F38B2.4

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.UniRule annotation

Catalytic activityi

ATP + AMP = 2 ADP.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei51 – 511AMPUniRule annotation
Binding sitei56 – 561AMPUniRule annotation
Binding sitei114 – 1141AMPUniRule annotation
Binding sitei145 – 1451ATPUniRule annotation
Binding sitei151 – 1511AMPUniRule annotation
Binding sitei162 – 1621AMPUniRule annotation
Binding sitei190 – 1901ATP; via carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi30 – 356ATPUniRule annotation
Nucleotide bindingi77 – 793AMPUniRule annotation
Nucleotide bindingi107 – 1104AMPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.4.3. 1045.
ReactomeiR-CEL-499943. Synthesis and interconversion of nucleotide di- and triphosphates.

Names & Taxonomyi

Protein namesi
Recommended name:
Adenylate kinase isoenzyme 1UniRule annotation (EC:2.7.4.3UniRule annotation)
Short name:
AK 1UniRule annotation
Alternative name(s):
ATP-AMP transphosphorylase 1UniRule annotation
ATP:AMP phosphotransferaseUniRule annotation
Adenylate monophosphate kinaseUniRule annotation
Gene namesi
ORF Names:F38B2.4
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome X

Organism-specific databases

WormBaseiF38B2.4a; CE02218; WBGene00009531.

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 210210Adenylate kinase isoenzyme 1PRO_0000158932Add
BLAST

Proteomic databases

EPDiQ20140.
PaxDbiQ20140.
PRIDEiQ20140.

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi6239.F38B2.4a.

Structurei

3D structure databases

ProteinModelPortaliQ20140.
SMRiQ20140. Positions 22-204.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni50 – 7930NMPbindUniRule annotationAdd
BLAST
Regioni144 – 15411LIDUniRule annotationAdd
BLAST

Domaini

Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.UniRule annotation

Sequence similaritiesi

Belongs to the adenylate kinase family. AK1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG3079. Eukaryota.
COG0563. LUCA.
GeneTreeiENSGT00390000016215.
HOGENOMiHOG000238771.
InParanoidiQ20140.
OMAiDCVLKKK.
OrthoDBiEOG7060S3.
PhylomeDBiQ20140.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00235. Adenylate_kinase_Adk.
MF_03171. Adenylate_kinase_AK1.
InterProiIPR000850. Adenylat/UMP-CMP_kin.
IPR028582. AK1.
IPR006267. AK1/5.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR23359. PTHR23359. 1 hit.
PRINTSiPR00094. ADENYLTKNASE.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01360. aden_kin_iso1. 1 hit.
PROSITEiPS00113. ADENYLATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q20140-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAPTVERKNI NLAPLKAAGV PIFFIVGGPG SGKGTQCDKI VAKYGLTHLS
60 70 80 90 100
SGDLLRDEVK SGSPRGAQLT AIMESGALVP LEVVLDLVKE AMLKAIEKGS
110 120 130 140 150
KGFLIDGYPR EVAQGQQFES EIQEAKLVLF FDVAEETLVK RLLHRAQTSG
160 170 180 190 200
RADDNADTIK KRLHTFVTST APVVDYYESK GKLVRINAEG SVDDIFAVVV
210
ANLDKATSKL
Length:210
Mass (Da):22,597
Last modified:November 1, 1996 - v1
Checksum:i786CB879D83DDFFC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z50045 Genomic DNA. Translation: CAA90364.1.
AF304123 mRNA. Translation: AAG50236.1.
PIRiT21947.
RefSeqiNP_001257141.1. NM_001270212.1.
UniGeneiCel.7837.

Genome annotation databases

EnsemblMetazoaiF38B2.4a; F38B2.4a; WBGene00009531.
GeneIDi181317.
KEGGicel:CELE_F38B2.4.
UCSCiF38B2.4. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z50045 Genomic DNA. Translation: CAA90364.1.
AF304123 mRNA. Translation: AAG50236.1.
PIRiT21947.
RefSeqiNP_001257141.1. NM_001270212.1.
UniGeneiCel.7837.

3D structure databases

ProteinModelPortaliQ20140.
SMRiQ20140. Positions 22-204.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi6239.F38B2.4a.

Proteomic databases

EPDiQ20140.
PaxDbiQ20140.
PRIDEiQ20140.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiF38B2.4a; F38B2.4a; WBGene00009531.
GeneIDi181317.
KEGGicel:CELE_F38B2.4.
UCSCiF38B2.4. c. elegans.

Organism-specific databases

CTDi181317.
WormBaseiF38B2.4a; CE02218; WBGene00009531.

Phylogenomic databases

eggNOGiKOG3079. Eukaryota.
COG0563. LUCA.
GeneTreeiENSGT00390000016215.
HOGENOMiHOG000238771.
InParanoidiQ20140.
OMAiDCVLKKK.
OrthoDBiEOG7060S3.
PhylomeDBiQ20140.

Enzyme and pathway databases

BRENDAi2.7.4.3. 1045.
ReactomeiR-CEL-499943. Synthesis and interconversion of nucleotide di- and triphosphates.

Miscellaneous databases

NextBioi913424.
PROiQ20140.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00235. Adenylate_kinase_Adk.
MF_03171. Adenylate_kinase_AK1.
InterProiIPR000850. Adenylat/UMP-CMP_kin.
IPR028582. AK1.
IPR006267. AK1/5.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR23359. PTHR23359. 1 hit.
PRINTSiPR00094. ADENYLTKNASE.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR01360. aden_kin_iso1. 1 hit.
PROSITEiPS00113. ADENYLATE_KINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of the nematode C. elegans: a platform for investigating biology."
    The C. elegans sequencing consortium
    Science 282:2012-2018(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bristol N2.
  2. "The Caenorhabditis elegans transcriptome project, a complementary view of the genome."
    Kohara Y., Shin-i T., Suzuki Y., Sugano S., Potdevin M., Thierry-Mieg Y., Thierry-Mieg D., Thierry-Mieg J.
    Submitted (SEP-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Bristol N2.

Entry informationi

Entry nameiKAD1_CAEEL
AccessioniPrimary (citable) accession number: Q20140
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: November 1, 1996
Last modified: March 16, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.