Reviewed,
UniProtKB/Swiss-Prot Q20117 (GSH1_CAEEL)
Last modified
June 16, 2009.
Version 53.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Glutamate--cysteine ligase EC=6.3.2.2 Alternative name(s): Gamma-glutamylcysteine synthetase Gamma-ECS Short name=GCS | ||||
| Gene names |
| ||||
| Organism | Caenorhabditis elegans [Complete proteome] | ||||
| Taxonomic identifier | 6239 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Protein attributes
| Sequence length | 654 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Catalytic activity | ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine. |
| Pathway | Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2. |
| Sequence similarities | Belongs to the glutamate--cysteine ligase type 3 family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Glutathione biosynthesis |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Ligase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | glutathione biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW glutamate-cysteine ligase activityInferred from electronic annotation. Source: EC protein bindingInferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 654 | 654 | Glutamate--cysteine ligase | PRO_0000192566 | |||
Sequences
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References
| [1] | "Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| Z54218 Genomic DNA. Translation: CAA90955.2. | |
| PIR | T21908. |
| RefSeq | NP_495927.2. |
| UniGene | Cel.17240 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q20117. 1 interaction. |
Genome annotation databases | |
| Ensembl | F37B12.2. Caenorhabditis elegans. [Contig view] |
| GeneID | 174438. |
| KEGG | cel:F37B12.2. |
Organism-specific databases | |
| WormBase | WBGene00001527. gcs-1. |
| WormPep | F37B12.2. CE32886. [WorfDB] |
Phylogenomic databases | |
| OMA | Q20117. FNTVEDN. |
Enzyme and pathway databases | |
| BRENDA | 6.3.2.2. 672. |
Gene expression databases | |
| ArrayExpress | Q20117. |
Family and domain databases | |
| InterPro | IPR004308. GCS. [Graphical view] |
| PANTHER | PTHR11164. GCS. 1 hit. |
| Pfam | PF03074. GCS. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 884042. |
Entry information
| Entry name | GSH1_CAEEL | ||||||||
| Accession | Primary (citable) accession number: Q20117 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Caenorhabditis annotation project | ||||||||
Relevant documents
| Caenorhabditis elegans Caenorhabditis elegans: entries, gene names and cross-references to WormPep |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


