Q20117 (GSH1_CAEEL) Reviewed, UniProtKB/Swiss-Prot
Last modified
November 16, 2011.
Version 72.
History...
Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Glutamate--cysteine ligase EC=6.3.2.2 Alternative name(s): Gamma-ECS Short name=GCS Gamma-glutamylcysteine synthetase | ||||
| Gene names |
| ||||
| Organism | Caenorhabditis elegans | ||||
| Taxonomic identifier | 6239 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis |
Protein attributes
| Sequence length | 654 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Catalytic activity | ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine. |
| Pathway | Sulfur metabolism; glutathione biosynthesis; glutathione from L-cysteine and L-glutamate: step 1/2. |
| Sequence similarities | Belongs to the glutamate--cysteine ligase type 3 family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Glutathione biosynthesis |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Ligase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | glutathione biosynthetic process Inferred from mutant phenotype. Source: WormBase response to arsenic-containing substanceInferred from mutant phenotype. Source: WormBase response to heatInferred from expression pattern. Source: WormBase response to herbicideInferred from expression pattern. Source: WormBase |
| Cellular component | cytoplasm Inferred from Biological aspect of Ancestor. Source: RefGenome |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW glutamate-cysteine ligase activityInferred from Biological aspect of Ancestor. Source: RefGenome protein bindingInferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| E01A2.1 | Q966L2 | 2 | EBI-311822,EBI-311817 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 654 | 654 | Glutamate--cysteine ligase | PRO_0000192566 | |||
Sequences
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References
| [1] | "Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | Z54218 Genomic DNA. Translation: CAA90955.2. |
| PIR | T21908. |
| RefSeq | NP_495927.2. NM_063526.4. |
| UniGene | Cel.17240. |
3D structure databases | |
| ProteinModelPortal | Q20117. |
| SMR | Q20117. Positions 2-636. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q20117. 1 interaction. |
| MINT | MINT-1060220. |
| STRING | Q20117. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblMetazoa | F37B12.2.1; F37B12.2.1; F37B12.2. F37B12.2.2; F37B12.2.2; F37B12.2. |
| GeneID | 174438. |
| KEGG | cel:F37B12.2. |
| UCSC | F37B12.2.1. c. elegans. |
Organism-specific databases | |
| CTD | 174438. |
| WormBase | F37B12.2; CE32886; WBGene00001527; gcs-1. |
Phylogenomic databases | |
| eggNOG | meNOG04688. |
| GeneTree | EMGT00050000016273. |
| HOGENOM | HBG331200. |
| InParanoid | Q20117. |
| OMA | QVTFQAC. |
| PhylomeDB | Q20117. |
Gene expression databases | |
| ArrayExpress | Q20117. |
Family and domain databases | |
| InterPro | IPR004308. GCS. [Graphical view] |
| KO | K11204. |
| PANTHER | PTHR11164. GCS. 1 hit. |
| Pfam | PF03074. GCS. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 884042. |
Entry information
| Entry name | GSH1_CAEEL | ||||||||
| Accession | Primary (citable) accession number: Q20117 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Caenorhabditis annotation project | ||||||||
Relevant documents
| Caenorhabditis elegans Caenorhabditis elegans: entries, gene names and cross-references to WormPep |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with