Q20086 (UGT58_CAEEL) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative UDP-glucuronosyltransferase ugt-58
Short name=UDPGT 58
EC=2.4.1.17

Gene names

Name:	ugt-58
Synonyms:	ugt5
ORF Names:	F35H8.6

Organism

Caenorhabditis elegans

Taxonomic identifier

6239 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Nematoda › Chromadorea › Rhabditida › Rhabditoidea › Rhabditidae › Peloderinae › Caenorhabditis

Protein attributes

Sequence length	533 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside.
Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the UDP-glycosyltransferase family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane Transmembrane helix
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glucuronosyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 16	16	Potential
	Chain	17 – 533	517	Putative UDP-glucuronosyltransferase ugt-58		PRO_0000036050
Regions
	Transmembrane	481 – 501	21	Helical; Potential
Amino acid modifications
	Glycosylation	88	1	N-linked (GlcNAc...) Potential
	Glycosylation	243	1	N-linked (GlcNAc...) Potential
	Glycosylation	336	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q20086 [UniParc]. Last modified December 6, 2002. Version 2. Checksum: B094511E73D55D46	FASTA	533	61,143
	10 20 30 40 50 60 MKSWLLLLGT IGWVTAGDVL FIPSTLYPVH AQTMSVLARE LAERGHKVTW LEIGPERSDI 70 80 90 100 110 120 VLHQQVSREF WPAQFGDRTL QEIYQFKNHT SHSELWNPQY TNENEQTTGW LASIRLCDSV 130 140 150 160 170 180 LSRSKSKFDK MVEKQFSTVI VDDLYNSCGV LMAGLKKSVY IYWSMTGLRT ESAWANQSPS 190 200 210 220 230 240 PPSYLPVAGT GLTDDLTFSQ RLYNVASYFK QLYIHQHIVQ PRIDAVFQKY YPGVESTFEI 250 260 270 280 290 300 ERNASINFVN TPPIFDFSRP YMPRVNFIGA IQCRKPKELP KEFTSWISAY PDGFVVLSTG 310 320 330 340 350 360 FTVQWNKSPE HIRQAYLDTF KYLPNLLFIW QTGLPNSSNL PSNLLVKPWL PLQDLLGHQK 370 380 390 400 410 420 CRCHVSHGGL NSVIESVYHG VPVVGVPLTS RGYDNLLRIT ARDSGVMVEK SEFSGEILTA 430 440 450 460 470 480 AINEVIENEK YKKEMLIFQD MVIDVPYTEL YHAAFWVEFI ERHQEVPHAR SGADHLNFLQ 490 500 510 520 530 YFLVDVIAFF FFVIFCTLSI IYYTIRTVFR TIRSVVNGVR GVPKIVSRGK KNN

References

[1]	"Genome sequence of the nematode C. elegans: a platform for investigating biology." The C. elegans sequencing consortium Science 282:2012-2018(1998) [PubMed: 9851916] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Bristol N2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z36752 Genomic DNA. Translation: CAA85328.2.
PIR	T21823.
RefSeq	NP_496059.2. NM_063658.5.
UniGene	Cel.17672.
3D structure databases
ProteinModelPortal	Q20086.
ModBase	Search...
Protein-protein interaction databases
STRING	Q20086.
Protein family/group databases
CAZy	GT1. Glycosyltransferase Family 1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblMetazoa	F35H8.6.1; F35H8.6.1; F35H8.6. F35H8.6.2; F35H8.6.2; F35H8.6.
GeneID	174507.
KEGG	cel:F35H8.6.
NMPDR	fig|6239.3.peg.6962.
UCSC	F35H8.6. c. elegans.
Organism-specific databases
CTD	174507.
WormBase	F35H8.6; CE00984; WBGene00009450; ugt-58.
Phylogenomic databases
eggNOG	meNOG12023.
GeneTree	EMGT00050000001225.
HOGENOM	HBG379367.
InParanoid	Q20086.
OMA	ERNASIN.
PhylomeDB	Q20086.
Gene expression databases
ArrayExpress	Q20086.
Family and domain databases
InterPro	IPR002213. UDP_glucos_trans. [Graphical view]
KO	K00699.
PANTHER	PTHR11926. UDP_glucos_trans. 1 hit.
Pfam	PF00201. UDPGT. 1 hit. [Graphical view]
PROSITE	PS00375. UDPGT. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	884324.

Entry information

Entry name

UGT58_CAEEL

Accession

Primary (citable) accession number: Q20086

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	December 6, 2002
Last modified:	November 16, 2011
This is version 73 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Caenorhabditis annotation project