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Protein

Zinc finger protein zfp-2

Gene

zfp-2

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Probable zinc finger transcription factor that acts as a transcriptional repressor. Acts redundantly with the transcriptional repressor lin-35 to control the development of somatic gonad lineages. May, in addition, suppress sensitivity to RNAi.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri171 – 194C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri200 – 222C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri229 – 251C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri255 – 278C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri300 – 322C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri328 – 350C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri356 – 379C2H2-type 7PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein zfp-2Imported
Gene namesi
Name:zfp-2Imported
ORF Names:F35H8.3Imported
OrganismiCaenorhabditis elegansImported
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome II

Organism-specific databases

WormBaseiF35H8.3; CE00981; WBGene00009448; zfp-2.

Subcellular locationi

  • Nucleus 1 Publication

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

No visible phenotype. Double knockout with lin-35 results in sterility, defects in gonad migration and vulval morphology.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004410151 – 422Zinc finger protein zfp-2CuratedAdd BLAST422

Proteomic databases

PaxDbiQ20082.

Expressioni

Tissue specificityi

Expressed in vulval cells and all somatic gonad structures such as spermatheca, sheath cells, uterine cells and distal tip cells.1 Publication

Gene expression databases

BgeeiWBGene00009448.

Interactioni

Protein-protein interaction databases

STRINGi6239.F35H8.3.

Structurei

3D structure databases

ProteinModelPortaliQ20082.
SMRiQ20082.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri171 – 194C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri200 – 222C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri229 – 251C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri255 – 278C2H2-type 4PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri300 – 322C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri328 – 350C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri356 – 379C2H2-type 7PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00880000137986.
HOGENOMiHOG000016220.
InParanoidiQ20082.
OMAiVEMDGEY.
OrthoDBiEOG091G0AMB.
PhylomeDBiQ20082.

Family and domain databases

Gene3Di3.30.40.10. 3 hits.
InterProiView protein in InterPro
IPR013087. Znf_C2H2_type.
IPR013083. Znf_RING/FYVE/PHD.
SMARTiView protein in SMART
SM00355. ZnF_C2H2. 7 hits.
SUPFAMiSSF57667. SSF57667. 3 hits.
PROSITEiView protein in PROSITE
PS00028. ZINC_FINGER_C2H2_1. 7 hits.
PS50157. ZINC_FINGER_C2H2_2. 7 hits.

Sequencei

Sequence statusi: Complete.

Q20082-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEMMMNDPS AMVIYEEEVT TAPNLPCSLI QQRSWDEEKP IGYELTNTKC
60 70 80 90 100
YKTPNGVQKT ATIQREQLST SKDFGEQQIV EMDGEFSIEG TDMHAIPCTS
110 120 130 140 150
SSMQPSTSSN PSSGEHQPVP LRRMAIKIGQ RVLRFKVISA EEAPEAPLDT
160 170 180 190 200
QDSWINDPKP VTTPKALAGL YRCTNCKTYF GNKEVYQRHI QEVHGDARPF
210 220 230 240 250
RCFNCGMRFA NKTSMTHHLK DHSLLKPMFS CDYCPRIFSK LESKTRHHKM
260 270 280 290 300
HFTRSTCQTC MRFFTTEDAL RHHQSTAHPA TFDSGPPPED LLPNGKSARY
310 320 330 340 350
SCSYCNLRFH FKKDMLVHER IHTGEKPYSC GYCMKSFAQS QALTAHIRTH
360 370 380 390 400
TKELPYGCGK CDKRFRDNSC LRKHELAAHT DEPIVRPISV AYSNQVQKQM
410 420
QRQRENRRKQ ELLIAERHPY RI
Length:422
Mass (Da):48,607
Last modified:November 1, 1996 - v1
Checksum:iCB3BF05E74B00E56
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX284602 Genomic DNA. Translation: CAA85325.1.
PIRiT21820.
RefSeqiNP_496055.1. NM_063654.4.
UniGeneiCel.15213.

Genome annotation databases

EnsemblMetazoaiF35H8.3; F35H8.3; WBGene00009448.
GeneIDi174505.
KEGGicel:CELE_F35H8.3.
UCSCiF35H8.3. c. elegans.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiZNF2_CAEEL
AccessioniPrimary (citable) accession number: Q20082
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2017
Last sequence update: November 1, 1996
Last modified: July 5, 2017
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase