ID   MIF_SHEEP               Reviewed;         115 AA.
AC   Q1ZZU7;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-APR-2006, sequence version 1.
DT   16-JUN-2009, entry version 15.
DE   RecName: Full=Macrophage migration inhibitory factor;
DE            Short=MIF;
DE            EC=5.3.2.1;
DE   AltName: Full=Phenylpyruvate tautomerase;
GN   Name=MIF;
OS   Ovis aries (Sheep).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia;
OC   Pecora; Bovidae; Caprinae; Ovis.
OX   NCBI_TaxID=9940;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Placenta;
RA   Lopes F., Ptak G., Arcuri F.;
RT   "The entire coding sequence of sheep macrophage migration inhibitory
RT   factor.";
RL   Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: The expression of MIF at sites of inflammation suggest a
CC       role for the mediator in regulating the function of macrophage in
CC       host defense. Also acts as a phenylpyruvate tautomerase (By
CC       similarity).
CC   -!- CATALYTIC ACTIVITY: Keto-phenylpyruvate = enol-phenylpyruvate.
CC   -!- SUBUNIT: Homotrimer. Interacts with COPS5 and BNIPL (By
CC       similarity).
CC   -!- SIMILARITY: Belongs to the MIF family.
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DR   EMBL; DQ414692; ABD67167.1; -; mRNA.
DR   RefSeq; NP_001072123.1; -.
DR   UniGene; Oar.4767; -.
DR   SMR; Q1ZZU7; 2-115.
DR   GeneID; 780466; -.
DR   HOVERGEN; Q1ZZU7; -.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0050178; F:phenylpyruvate tautomerase activity; IEA:EC.
DR   GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR   InterPro; IPR001398; Macrophage_inhib_fac.
DR   InterPro; IPR019829; Macrophage_inhib_fac_CS.
DR   InterPro; IPR014347; Tautomerase.
DR   Gene3D; G3DSA:3.30.429.10; Tautomerase; 1.
DR   PANTHER; PTHR11954; MIF; 1.
DR   Pfam; PF01187; MIF; 1.
DR   ProDom; PD004816; MIF; 1.
DR   PROSITE; PS01158; MIF; 1.
PE   3: Inferred from homology;
KW   Cytokine; Inflammatory response; Isomerase; Phosphoprotein.
FT   INIT_MET      1      1       Removed (By similarity).
FT   CHAIN         2    115       Macrophage migration inhibitory factor.
FT                                /FTId=PRO_0000344369.
FT   ACT_SITE      2      2       Proton acceptor; via imino nitrogen (By
FT                                similarity).
FT   MOD_RES      37     37       Phosphotyrosine (By similarity).
SQ   SEQUENCE   115 AA;  12343 MW;  750242BFF691975E CRC64;
     MPMFVVNTNV PRASVPDGLL SELTQQLAQA TGKPAQYIAV HVVPDQLMTF GGSSEPCALC
     SLHSIGKIGG AQNRSYSKLL CGLLTERLRI SPDRIYINFC DMNAANVGWN GSTFA
//