Reviewed, UniProtKB/Swiss-Prot Q1ZZU7 (MIF_SHEEP)

Names and origin

Protein names

Recommended name:
    Macrophage migration inhibitory factor
      Short name=MIF
    EC=5.3.2.1
Alternative name(s):
    Phenylpyruvate tautomerase

Gene names

Name:

MIF

Organism

Ovis aries (Sheep)

Taxonomic identifier

9940 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Caprinae › Ovis

Protein attributes

Sequence length	115 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	The expression of MIF at sites of inflammation suggest a role for the mediator in regulating the function of macrophage in host defense. Also acts as a phenylpyruvate tautomerase By similarity.
Catalytic activity	Keto-phenylpyruvate = enol-phenylpyruvate.
Subunit structure	Homotrimer. Interacts with COPS5 and BNIPL By similarity.
Sequence similarities	Belongs to the MIF family.

Ontologies

Keywords
Biological process	Inflammatory response
Molecular function	Cytokine Isomerase
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	inflammatory response Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular space Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	cytokine activity Inferred from electronic annotation. Source: UniProtKB-KW phenylpyruvate tautomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity
	Chain	2 – 115	114	Macrophage migration inhibitory factor		PRO_0000344369
Sites
	Active site	2	1	Proton acceptor; via imino nitrogen By similarity
Amino acid modifications
	Modified residue	37	1	Phosphotyrosine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1ZZU7-1 [UniParc]. Last modified April 18, 2006. Version 1. Checksum: 750242BFF691975E	FASTA	115	12,343
	10 20 30 40 50 60 MPMFVVNTNV PRASVPDGLL SELTQQLAQA TGKPAQYIAV HVVPDQLMTF GGSSEPCALC 70 80 90 100 110 SLHSIGKIGG AQNRSYSKLL CGLLTERLRI SPDRIYINFC DMNAANVGWN GSTFA

References

[1]	"The entire coding sequence of sheep macrophage migration inhibitory factor." Lopes F., Ptak G., Arcuri F. Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Placenta.

Cross-references

Sequence databases
EMBLGenBankDDBJ	DQ414692 mRNA. Translation: ABD67167.1.
RefSeq	NP_001072123.1.
UniGene	Oar.4767
3D structure databases
SMR	Q1ZZU7. Positions 2-115.
ModBase	Search...
Genome annotation databases
GeneID	780466.
Phylogenomic databases
HOVERGEN	Q1ZZU7.
Family and domain databases
InterPro	IPR001398. Macrophage_inhib_fac. IPR019829. Macrophage_inhib_fac_CS. IPR014347. Tautomerase. [Graphical view]
Gene3D	G3DSA:3.30.429.10. Tautomerase. 1 hit.
PANTHER	PTHR11954. MIF. 1 hit.
Pfam	PF01187. MIF. 1 hit. [Graphical view]
ProDom	PD004816. MIF. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS01158. MIF. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MIF_SHEEP

Accession

Primary (citable) accession number: Q1ZZU7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 22, 2008
Last sequence update:	April 18, 2006
Last modified:	June 16, 2009
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)