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Protein

DNA repair protein SWI5 homolog

Gene

SWI5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination.1 Publication

GO - Biological processi

  • cellular response to ionizing radiation Source: UniProtKB
  • DNA recombinase assembly Source: GO_Central
  • double-strand break repair via homologous recombination Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
DNA repair protein SWI5 homolog
Alternative name(s):
HBV DNAPTP1-transactivated protein A
Protein SAE3 homolog
Gene namesi
Name:SWI5
Synonyms:C9orf119, SAE3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:31412. SWI5.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: UniProtKB
  • Swi5-Sfr1 complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi173L → P: Does not affect interaction with SFR1/MEI5. 1 Publication1

Organism-specific databases

DisGeNETi375757.
OpenTargetsiENSG00000175854.
PharmGKBiPA134903574.

Polymorphism and mutation databases

BioMutaiSWI5.
DMDMi121940938.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003245841 – 235DNA repair protein SWI5 homologAdd BLAST235

Proteomic databases

EPDiQ1ZZU3.
MaxQBiQ1ZZU3.
PaxDbiQ1ZZU3.
PeptideAtlasiQ1ZZU3.
PRIDEiQ1ZZU3.

PTM databases

iPTMnetiQ1ZZU3.
PhosphoSitePlusiQ1ZZU3.

Expressioni

Gene expression databases

BgeeiENSG00000175854.
CleanExiHS_C9orf119.
ExpressionAtlasiQ1ZZU3. baseline and differential.
GenevisibleiQ1ZZU3. HS.

Organism-specific databases

HPAiHPA052032.
HPA055472.

Interactioni

Subunit structurei

Component of the SWI5-SFR1 complex. Interacts with RAD51.2 Publications

Protein-protein interaction databases

BioGridi131997. 2 interactors.
STRINGi9606.ENSP00000316609.

Structurei

3D structure databases

ProteinModelPortaliQ1ZZU3.
SMRiQ1ZZU3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili156 – 183Sequence analysisAdd BLAST28

Sequence similaritiesi

Belongs to the SWI5/SAE3 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410J117. Eukaryota.
ENOG410XYJT. LUCA.
GeneTreeiENSGT00390000009349.
InParanoidiQ1ZZU3.
OrthoDBiEOG091G1C5U.
PhylomeDBiQ1ZZU3.
TreeFamiTF336078.

Family and domain databases

InterProiIPR010760. DNA-repair_Swi5.
[Graphical view]
PfamiPF07061. Swi5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1ZZU3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRRGQRDLW RHNKSCARNR CPRPPRERGG AGFPWVRAQL SVRQFTLRVR
60 70 80 90 100
VPGPVHLRGR SPTPALDPLA PLNPLIRGPR TPGLRRWIQS LALLLPNCSS
110 120 130 140 150
SRIPTVPRPH SGLWVQSDFP LGFLSRTEPR LTRSCRGAFR SPRPLPKSGQ
160 170 180 190 200
ADGTSEESLH LDIQKLKEKR DMLDKEISQF VSEGYSVDEL EDHITQLHEY
210 220 230
NDIKDVGQML MGKLAVIRGV TTKELYPEFG LDMND
Length:235
Mass (Da):26,739
Last modified:April 18, 2006 - v1
Checksum:i5DCA1CE228987987
GO

Sequence cautioni

The sequence CAI13840 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI13843 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAI13844 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ414820 mRNA. Translation: ABD72916.1.
AL590708 Genomic DNA. Translation: CAI13840.1. Sequence problems.
AL590708 Genomic DNA. Translation: CAI13843.1. Different initiation.
AL590708 Genomic DNA. Translation: CAI13844.1. Sequence problems.
BC029911 mRNA. Translation: AAH29911.1.
CCDSiCCDS43883.1.
RefSeqiNP_001035100.1. NM_001040011.1.
NP_001305018.1. NM_001318089.1.
NP_001305021.1. NM_001318092.1.
UniGeneiHs.259594.

Genome annotation databases

EnsembliENST00000320188; ENSP00000316609; ENSG00000175854.
GeneIDi375757.
KEGGihsa:375757.
UCSCiuc004bup.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ414820 mRNA. Translation: ABD72916.1.
AL590708 Genomic DNA. Translation: CAI13840.1. Sequence problems.
AL590708 Genomic DNA. Translation: CAI13843.1. Different initiation.
AL590708 Genomic DNA. Translation: CAI13844.1. Sequence problems.
BC029911 mRNA. Translation: AAH29911.1.
CCDSiCCDS43883.1.
RefSeqiNP_001035100.1. NM_001040011.1.
NP_001305018.1. NM_001318089.1.
NP_001305021.1. NM_001318092.1.
UniGeneiHs.259594.

3D structure databases

ProteinModelPortaliQ1ZZU3.
SMRiQ1ZZU3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi131997. 2 interactors.
STRINGi9606.ENSP00000316609.

PTM databases

iPTMnetiQ1ZZU3.
PhosphoSitePlusiQ1ZZU3.

Polymorphism and mutation databases

BioMutaiSWI5.
DMDMi121940938.

Proteomic databases

EPDiQ1ZZU3.
MaxQBiQ1ZZU3.
PaxDbiQ1ZZU3.
PeptideAtlasiQ1ZZU3.
PRIDEiQ1ZZU3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320188; ENSP00000316609; ENSG00000175854.
GeneIDi375757.
KEGGihsa:375757.
UCSCiuc004bup.4. human.

Organism-specific databases

CTDi375757.
DisGeNETi375757.
GeneCardsiSWI5.
H-InvDBHIX0025860.
HGNCiHGNC:31412. SWI5.
HPAiHPA052032.
HPA055472.
MIMi616528. gene.
neXtProtiNX_Q1ZZU3.
OpenTargetsiENSG00000175854.
PharmGKBiPA134903574.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J117. Eukaryota.
ENOG410XYJT. LUCA.
GeneTreeiENSGT00390000009349.
InParanoidiQ1ZZU3.
OrthoDBiEOG091G1C5U.
PhylomeDBiQ1ZZU3.
TreeFamiTF336078.

Miscellaneous databases

ChiTaRSiSWI5. human.
GenomeRNAii375757.
PROiQ1ZZU3.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000175854.
CleanExiHS_C9orf119.
ExpressionAtlasiQ1ZZU3. baseline and differential.
GenevisibleiQ1ZZU3. HS.

Family and domain databases

InterProiIPR010760. DNA-repair_Swi5.
[Graphical view]
PfamiPF07061. Swi5. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSWI5_HUMAN
AccessioniPrimary (citable) accession number: Q1ZZU3
Secondary accession number(s): Q5SYX7, Q5SYX8, Q8N2W6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: April 18, 2006
Last modified: November 2, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.