Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q1ZZU3

- SWI5_HUMAN

UniProt

Q1ZZU3 - SWI5_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

DNA repair protein SWI5 homolog

Gene

SWI5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination.1 Publication

GO - Biological processi

  1. cellular response to ionizing radiation Source: UniProtKB
  2. double-strand break repair via homologous recombination Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

DNA damage, DNA repair

Names & Taxonomyi

Protein namesi
Recommended name:
DNA repair protein SWI5 homolog
Alternative name(s):
HBV DNAPTP1-transactivated protein A
Protein SAE3 homolog
Gene namesi
Name:SWI5
Synonyms:C9orf119, SAE3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:31412. SWI5.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB
  2. Swi5-Sfr1 complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi173 – 1731L → P: Does not affect interaction with SFR1/MEI5. 1 Publication

Organism-specific databases

PharmGKBiPA134903574.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 235235DNA repair protein SWI5 homologPRO_0000324584Add
BLAST

Proteomic databases

MaxQBiQ1ZZU3.
PaxDbiQ1ZZU3.
PRIDEiQ1ZZU3.

PTM databases

PhosphoSiteiQ1ZZU3.

Expressioni

Gene expression databases

BgeeiQ1ZZU3.
CleanExiHS_C9orf119.
ExpressionAtlasiQ1ZZU3. baseline and differential.
GenevestigatoriQ1ZZU3.

Organism-specific databases

HPAiHPA052032.

Interactioni

Subunit structurei

Component of the SWI5-SFR1 complex. Interacts with RAD51.2 Publications

Protein-protein interaction databases

BioGridi131997. 3 interactions.
STRINGi9606.ENSP00000316609.

Structurei

3D structure databases

ProteinModelPortaliQ1ZZU3.
SMRiQ1ZZU3. Positions 166-232.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili156 – 18328Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the SWI5/SAE3 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG40898.
GeneTreeiENSGT00390000009349.
InParanoidiQ1ZZU3.
OMAiNKSCARN.
PhylomeDBiQ1ZZU3.
TreeFamiTF336078.

Family and domain databases

InterProiIPR010760. DNA-repair_Swi5.
[Graphical view]
PfamiPF07061. Swi5. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1ZZU3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQRRGQRDLW RHNKSCARNR CPRPPRERGG AGFPWVRAQL SVRQFTLRVR
60 70 80 90 100
VPGPVHLRGR SPTPALDPLA PLNPLIRGPR TPGLRRWIQS LALLLPNCSS
110 120 130 140 150
SRIPTVPRPH SGLWVQSDFP LGFLSRTEPR LTRSCRGAFR SPRPLPKSGQ
160 170 180 190 200
ADGTSEESLH LDIQKLKEKR DMLDKEISQF VSEGYSVDEL EDHITQLHEY
210 220 230
NDIKDVGQML MGKLAVIRGV TTKELYPEFG LDMND
Length:235
Mass (Da):26,739
Last modified:April 18, 2006 - v1
Checksum:i5DCA1CE228987987
GO

Sequence cautioni

The sequence CAI13843.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence CAI13840.1 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAI13844.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ414820 mRNA. Translation: ABD72916.1.
AL590708 Genomic DNA. Translation: CAI13840.1. Sequence problems.
AL590708 Genomic DNA. Translation: CAI13843.1. Different initiation.
AL590708 Genomic DNA. Translation: CAI13844.1. Sequence problems.
BC029911 mRNA. Translation: AAH29911.1.
CCDSiCCDS43883.1.
RefSeqiNP_001035100.1. NM_001040011.1.
UniGeneiHs.259594.

Genome annotation databases

EnsembliENST00000320188; ENSP00000316609; ENSG00000175854.
GeneIDi375757.
KEGGihsa:375757.
UCSCiuc004bup.3. human.

Polymorphism databases

DMDMi121940938.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DQ414820 mRNA. Translation: ABD72916.1 .
AL590708 Genomic DNA. Translation: CAI13840.1 . Sequence problems.
AL590708 Genomic DNA. Translation: CAI13843.1 . Different initiation.
AL590708 Genomic DNA. Translation: CAI13844.1 . Sequence problems.
BC029911 mRNA. Translation: AAH29911.1 .
CCDSi CCDS43883.1.
RefSeqi NP_001035100.1. NM_001040011.1.
UniGenei Hs.259594.

3D structure databases

ProteinModelPortali Q1ZZU3.
SMRi Q1ZZU3. Positions 166-232.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 131997. 3 interactions.
STRINGi 9606.ENSP00000316609.

PTM databases

PhosphoSitei Q1ZZU3.

Polymorphism databases

DMDMi 121940938.

Proteomic databases

MaxQBi Q1ZZU3.
PaxDbi Q1ZZU3.
PRIDEi Q1ZZU3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000320188 ; ENSP00000316609 ; ENSG00000175854 .
GeneIDi 375757.
KEGGi hsa:375757.
UCSCi uc004bup.3. human.

Organism-specific databases

CTDi 375757.
GeneCardsi GC09P131059.
H-InvDB HIX0025860.
HGNCi HGNC:31412. SWI5.
HPAi HPA052032.
neXtProti NX_Q1ZZU3.
PharmGKBi PA134903574.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG40898.
GeneTreei ENSGT00390000009349.
InParanoidi Q1ZZU3.
OMAi NKSCARN.
PhylomeDBi Q1ZZU3.
TreeFami TF336078.

Miscellaneous databases

ChiTaRSi SWI5. human.
GenomeRNAii 375757.
NextBioi 100599.
PROi Q1ZZU3.

Gene expression databases

Bgeei Q1ZZU3.
CleanExi HS_C9orf119.
ExpressionAtlasi Q1ZZU3. baseline and differential.
Genevestigatori Q1ZZU3.

Family and domain databases

InterProi IPR010760. DNA-repair_Swi5.
[Graphical view ]
Pfami PF07061. Swi5. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Homo sapiens HBV DNAPTP1-transactivated protein A."
    Lun Y.Z., Cheng J., Guo J., Zhang L.Y., Zhao B.C.
    Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 27-235.
    Tissue: Brain.
  4. "The role of human SWI5-MEI5 complex in homologous recombination repair."
    Yuan J., Chen J.
    J. Biol. Chem. 286:9888-9893(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, IDENTIFICATION IN THE SWI5-SFR1 COMPLEX, INTERACTION WITH RAD51, MUTAGENESIS OF LEU-173.
  5. "FIGNL1-containing protein complex is required for efficient homologous recombination repair."
    Yuan J., Chen J.
    Proc. Natl. Acad. Sci. U.S.A. 110:10640-10645(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH RAD51.

Entry informationi

Entry nameiSWI5_HUMAN
AccessioniPrimary (citable) accession number: Q1ZZU3
Secondary accession number(s): Q5SYX7, Q5SYX8, Q8N2W6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: April 18, 2006
Last modified: October 29, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3