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Q1ZZU3 (SWI5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
DNA repair protein SWI5 homolog
Alternative name(s):
HBV DNAPTP1-transactivated protein A
Protein SAE3 homolog
Gene names
Name:SWI5
Synonyms:C9orf119, SAE3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length235 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination. Ref.4

Subunit structure

Component of the SWI5-SFR1 complex. Interacts with RAD51. Ref.4 Ref.5

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the SWI5/SAE3 family.

Sequence caution

The sequence CAI13840.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence CAI13843.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence CAI13844.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 235235DNA repair protein SWI5 homolog
PRO_0000324584

Regions

Coiled coil156 – 18328 Potential

Experimental info

Mutagenesis1731L → P: Does not affect interaction with SFR1/MEI5. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q1ZZU3 [UniParc].

Last modified April 18, 2006. Version 1.
Checksum: 5DCA1CE228987987

FASTA23526,739
        10         20         30         40         50         60 
MQRRGQRDLW RHNKSCARNR CPRPPRERGG AGFPWVRAQL SVRQFTLRVR VPGPVHLRGR 

        70         80         90        100        110        120 
SPTPALDPLA PLNPLIRGPR TPGLRRWIQS LALLLPNCSS SRIPTVPRPH SGLWVQSDFP 

       130        140        150        160        170        180 
LGFLSRTEPR LTRSCRGAFR SPRPLPKSGQ ADGTSEESLH LDIQKLKEKR DMLDKEISQF 

       190        200        210        220        230 
VSEGYSVDEL EDHITQLHEY NDIKDVGQML MGKLAVIRGV TTKELYPEFG LDMND 

« Hide

References

« Hide 'large scale' references
[1]"Homo sapiens HBV DNAPTP1-transactivated protein A."
Lun Y.Z., Cheng J., Guo J., Zhang L.Y., Zhao B.C.
Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 27-235.
Tissue: Brain.
[4]"The role of human SWI5-MEI5 complex in homologous recombination repair."
Yuan J., Chen J.
J. Biol. Chem. 286:9888-9893(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, IDENTIFICATION IN THE SWI5-SFR1 COMPLEX, INTERACTION WITH RAD51, MUTAGENESIS OF LEU-173.
[5]"FIGNL1-containing protein complex is required for efficient homologous recombination repair."
Yuan J., Chen J.
Proc. Natl. Acad. Sci. U.S.A. 110:10640-10645(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH RAD51.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ414820 mRNA. Translation: ABD72916.1.
AL590708 Genomic DNA. Translation: CAI13840.1. Sequence problems.
AL590708 Genomic DNA. Translation: CAI13843.1. Different initiation.
AL590708 Genomic DNA. Translation: CAI13844.1. Sequence problems.
BC029911 mRNA. Translation: AAH29911.1.
RefSeqNP_001035100.1. NM_001040011.1.
UniGeneHs.259594.

3D structure databases

ProteinModelPortalQ1ZZU3.
SMRQ1ZZU3. Positions 166-232.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid131997. 3 interactions.
STRING9606.ENSP00000316609.

PTM databases

PhosphoSiteQ1ZZU3.

Polymorphism databases

DMDM121940938.

Proteomic databases

PaxDbQ1ZZU3.
PRIDEQ1ZZU3.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000320188; ENSP00000316609; ENSG00000175854.
GeneID375757.
KEGGhsa:375757.
UCSCuc004bup.3. human.

Organism-specific databases

CTD375757.
GeneCardsGC09P131044.
H-InvDBHIX0025860.
HGNCHGNC:31412. SWI5.
HPAHPA052032.
neXtProtNX_Q1ZZU3.
PharmGKBPA134903574.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG40898.
InParanoidQ1ZZU3.
OMANCSSSRI.
PhylomeDBQ1ZZU3.
TreeFamTF336078.

Gene expression databases

BgeeQ1ZZU3.
CleanExHS_C9orf119.
GenevestigatorQ1ZZU3.

Family and domain databases

InterProIPR010760. DNA-repair_Swi5.
[Graphical view]
PfamPF07061. Swi5. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSWI5. human.
GenomeRNAi375757.
NextBio100599.
PROQ1ZZU3.

Entry information

Entry nameSWI5_HUMAN
AccessionPrimary (citable) accession number: Q1ZZU3
Secondary accession number(s): Q5SYX7, Q5SYX8, Q8N2W6
Entry history
Integrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: April 18, 2006
Last modified: April 16, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM