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Q1ZZU3

- SWI5_HUMAN

UniProt

Q1ZZU3 - SWI5_HUMAN

Protein

DNA repair protein SWI5 homolog

Gene

SWI5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (18 Apr 2006)
      Previous versions | rss
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    Functioni

    Component of the SWI5-SFR1 complex, a complex required for double-strand break repair via homologous recombination.1 Publication

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. cellular response to ionizing radiation Source: UniProtKB
    2. double-strand break repair via homologous recombination Source: UniProtKB

    Keywords - Biological processi

    DNA damage, DNA repair

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA repair protein SWI5 homolog
    Alternative name(s):
    HBV DNAPTP1-transactivated protein A
    Protein SAE3 homolog
    Gene namesi
    Name:SWI5
    Synonyms:C9orf119, SAE3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:31412. SWI5.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. nucleus Source: UniProtKB
    2. Swi5-Sfr1 complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi173 – 1731L → P: Does not affect interaction with SFR1/MEI5. 1 Publication

    Organism-specific databases

    PharmGKBiPA134903574.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 235235DNA repair protein SWI5 homologPRO_0000324584Add
    BLAST

    Proteomic databases

    MaxQBiQ1ZZU3.
    PaxDbiQ1ZZU3.
    PRIDEiQ1ZZU3.

    PTM databases

    PhosphoSiteiQ1ZZU3.

    Expressioni

    Gene expression databases

    BgeeiQ1ZZU3.
    CleanExiHS_C9orf119.
    GenevestigatoriQ1ZZU3.

    Organism-specific databases

    HPAiHPA052032.

    Interactioni

    Subunit structurei

    Component of the SWI5-SFR1 complex. Interacts with RAD51.2 Publications

    Protein-protein interaction databases

    BioGridi131997. 3 interactions.
    STRINGi9606.ENSP00000316609.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1ZZU3.
    SMRiQ1ZZU3. Positions 166-232.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili156 – 18328Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SWI5/SAE3 family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG40898.
    InParanoidiQ1ZZU3.
    OMAiNKSCARN.
    PhylomeDBiQ1ZZU3.
    TreeFamiTF336078.

    Family and domain databases

    InterProiIPR010760. DNA-repair_Swi5.
    [Graphical view]
    PfamiPF07061. Swi5. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1ZZU3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQRRGQRDLW RHNKSCARNR CPRPPRERGG AGFPWVRAQL SVRQFTLRVR    50
    VPGPVHLRGR SPTPALDPLA PLNPLIRGPR TPGLRRWIQS LALLLPNCSS 100
    SRIPTVPRPH SGLWVQSDFP LGFLSRTEPR LTRSCRGAFR SPRPLPKSGQ 150
    ADGTSEESLH LDIQKLKEKR DMLDKEISQF VSEGYSVDEL EDHITQLHEY 200
    NDIKDVGQML MGKLAVIRGV TTKELYPEFG LDMND 235
    Length:235
    Mass (Da):26,739
    Last modified:April 18, 2006 - v1
    Checksum:i5DCA1CE228987987
    GO

    Sequence cautioni

    The sequence CAI13843.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence CAI13840.1 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI13844.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ414820 mRNA. Translation: ABD72916.1.
    AL590708 Genomic DNA. Translation: CAI13840.1. Sequence problems.
    AL590708 Genomic DNA. Translation: CAI13843.1. Different initiation.
    AL590708 Genomic DNA. Translation: CAI13844.1. Sequence problems.
    BC029911 mRNA. Translation: AAH29911.1.
    CCDSiCCDS43883.1.
    RefSeqiNP_001035100.1. NM_001040011.1.
    UniGeneiHs.259594.

    Genome annotation databases

    EnsembliENST00000320188; ENSP00000316609; ENSG00000175854.
    GeneIDi375757.
    KEGGihsa:375757.
    UCSCiuc004bup.3. human.

    Polymorphism databases

    DMDMi121940938.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ414820 mRNA. Translation: ABD72916.1 .
    AL590708 Genomic DNA. Translation: CAI13840.1 . Sequence problems.
    AL590708 Genomic DNA. Translation: CAI13843.1 . Different initiation.
    AL590708 Genomic DNA. Translation: CAI13844.1 . Sequence problems.
    BC029911 mRNA. Translation: AAH29911.1 .
    CCDSi CCDS43883.1.
    RefSeqi NP_001035100.1. NM_001040011.1.
    UniGenei Hs.259594.

    3D structure databases

    ProteinModelPortali Q1ZZU3.
    SMRi Q1ZZU3. Positions 166-232.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 131997. 3 interactions.
    STRINGi 9606.ENSP00000316609.

    PTM databases

    PhosphoSitei Q1ZZU3.

    Polymorphism databases

    DMDMi 121940938.

    Proteomic databases

    MaxQBi Q1ZZU3.
    PaxDbi Q1ZZU3.
    PRIDEi Q1ZZU3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000320188 ; ENSP00000316609 ; ENSG00000175854 .
    GeneIDi 375757.
    KEGGi hsa:375757.
    UCSCi uc004bup.3. human.

    Organism-specific databases

    CTDi 375757.
    GeneCardsi GC09P131044.
    H-InvDB HIX0025860.
    HGNCi HGNC:31412. SWI5.
    HPAi HPA052032.
    neXtProti NX_Q1ZZU3.
    PharmGKBi PA134903574.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG40898.
    InParanoidi Q1ZZU3.
    OMAi NKSCARN.
    PhylomeDBi Q1ZZU3.
    TreeFami TF336078.

    Miscellaneous databases

    ChiTaRSi SWI5. human.
    GenomeRNAii 375757.
    NextBioi 100599.
    PROi Q1ZZU3.

    Gene expression databases

    Bgeei Q1ZZU3.
    CleanExi HS_C9orf119.
    Genevestigatori Q1ZZU3.

    Family and domain databases

    InterProi IPR010760. DNA-repair_Swi5.
    [Graphical view ]
    Pfami PF07061. Swi5. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Homo sapiens HBV DNAPTP1-transactivated protein A."
      Lun Y.Z., Cheng J., Guo J., Zhang L.Y., Zhao B.C.
      Submitted (FEB-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 27-235.
      Tissue: Brain.
    4. "The role of human SWI5-MEI5 complex in homologous recombination repair."
      Yuan J., Chen J.
      J. Biol. Chem. 286:9888-9893(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, IDENTIFICATION IN THE SWI5-SFR1 COMPLEX, INTERACTION WITH RAD51, MUTAGENESIS OF LEU-173.
    5. "FIGNL1-containing protein complex is required for efficient homologous recombination repair."
      Yuan J., Chen J.
      Proc. Natl. Acad. Sci. U.S.A. 110:10640-10645(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH RAD51.

    Entry informationi

    Entry nameiSWI5_HUMAN
    AccessioniPrimary (citable) accession number: Q1ZZU3
    Secondary accession number(s): Q5SYX7, Q5SYX8, Q8N2W6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 18, 2008
    Last sequence update: April 18, 2006
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3