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Protein

Fatty acyl-CoA synthetase B

Gene

fcsB

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Long chain fatty acid acyl-CoA synthetases catalyze the formation of a thiester bond between a free fatty acid and coenzyme A during fatty acid metabolic process.By similarity

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • decanoate-CoA ligase activity Source: UniProtKB-EC
  • long-chain fatty acid-CoA ligase activity Source: dictyBase

GO - Biological processi

  • fatty acid metabolic process Source: dictyBase
  • positive regulation of phagocytosis Source: dictyBase

Keywordsi

Molecular functionLigase
Biological processFatty acid metabolism, Lipid metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DDI-2046105 Linoleic acid (LA) metabolism
R-DDI-2046106 alpha-linolenic acid (ALA) metabolism
R-DDI-75876 Synthesis of very long-chain fatty acyl-CoAs

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acyl-CoA synthetase B (EC:6.2.1.3)
Alternative name(s):
Long chain fatty acyl coenzyme A-synthetase 2
Short name:
LC-FACS 2
Long-chain-fatty-acid--CoA synthetase 2
Gene namesi
Name:fcsB
ORF Names:DDB_G0269474
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 1, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0269474 fcsB

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum Source: dictyBase
  • integral component of membrane Source: dictyBase
  • peroxisome Source: dictyBase

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000038443919 – 673Fatty acyl-CoA synthetase BAdd BLAST655

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi267N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ1ZXQ4

Expressioni

Inductioni

Down-regulated by Pseudomonas aeruginosa, PAO1 strain and PA14 strain infection.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0231574

Structurei

3D structure databases

ProteinModelPortaliQ1ZXQ4
SMRiQ1ZXQ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1256 Eukaryota
COG1022 LUCA
InParanoidiQ1ZXQ4
KOiK01897
OMAiSVLPIWH
PhylomeDBiQ1ZXQ4

Family and domain databases

InterProiView protein in InterPro
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
PfamiView protein in Pfam
PF00501 AMP-binding, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q1ZXQ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINNWLAVGL LVVSGILAFN WKRKHPYGQT VEIGEKPENG GRIRRNSACA
60 70 80 90 100
DHLISFLEDD EIYTLYDSLV KSCKKYGERK CFGERKKDSN GNLGKFEWIS
110 120 130 140 150
YNTYLERCEY IQQGLCELGL KPKSKVGIFS KNRLEWLIVH SASFIQSYCV
160 170 180 190 200
VSFYETLGVE SLSYVTEHAE IGLAFCSAET LQKTLDIAKG VKVLKTIICF
210 220 230 240 250
DSIDKEHYNI AKELGVTLYT YDEIMKKGKE ANGKHKHTPP TPDTLSTIMY
260 270 280 290 300
TSGTTGPPKG VMITHKNLTS VVCAVSDFIK VYDTDVHYSY LPYAHVLERV
310 320 330 340 350
VILAAFHFGA AIGIFSGDIS NILVEVKLLS PTLFIGVPRV FERIKTNVFK
360 370 380 390 400
EISKKPALLR TLFNGAYNLK YLSIQHGFKL PIIEKVLDLV FFSKIKQALG
410 420 430 440 450
GKVRVILSGS APLSFDTEVF LRVVMCCCVL QGYGASEGCG GDACKRLDDE
460 470 480 490 500
SVGTIGPPFA SNEIKLVDVP ELGYDSNGEV QTGEVCLRGP SISSGYYKDE
510 520 530 540 550
EKTREEFKDG WFHTGDIGRW NRDGSLSIVD RKKNIFKLSQ GEYVAVEKIE
560 570 580 590 600
TIVVKSEYVE QVCIYGDSQK SCVIAIIHPH PESCSEWAGS KKTDKDIKEI
610 620 630 640 650
CKNQDFIKVV LDDIIKNCKK SGLHGFEIPK AIHLTPEAFS DQNNLLTPSF
660 670
KLKRHEIKKY FEDEIKKLYS KLD
Length:673
Mass (Da):75,581
Last modified:May 2, 2006 - v1
Checksum:i6E1987AAB92B9D8D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000005 Genomic DNA Translation: EAS66934.1
RefSeqiXP_001134470.1, XM_001134470.1

Genome annotation databases

EnsemblProtistsiEAS66934; EAS66934; DDB_G0269474
GeneIDi8616941
KEGGiddi:DDB_G0269474

Similar proteinsi

Entry informationi

Entry nameiFCSB_DICDI
AccessioniPrimary (citable) accession number: Q1ZXQ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 2, 2006
Last modified: April 25, 2018
This is version 71 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health