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Q1ZXQ4

- FCSB_DICDI

UniProt

Q1ZXQ4 - FCSB_DICDI

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Protein

Fatty acyl-CoA synthetase B

Gene

fcsB

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Long chain fatty acid acyl-CoA synthetases catalyze the formation of a thiester bond between a free fatty acid and coenzyme A during fatty acid metabolic process.By similarity

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. long-chain fatty acid-CoA ligase activity Source: dictyBase

GO - Biological processi

  1. fatty acid metabolic process Source: dictyBase
  2. long-chain fatty acid metabolic process Source: GOC
  3. positive regulation of phagocytosis Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acyl-CoA synthetase B (EC:6.2.1.3)
Alternative name(s):
Long chain fatty acyl coenzyme A-synthetase 2
Short name:
LC-FACS 2
Long-chain-fatty-acid--CoA synthetase 2
Gene namesi
Name:fcsB
ORF Names:DDB_G0269474
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 1, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0269474. fcsB.

Subcellular locationi

Endoplasmic reticulum 1 Publication

GO - Cellular componenti

  1. endoplasmic reticulum Source: dictyBase
  2. integral component of membrane Source: dictyBase
  3. peroxisome Source: dictyBase
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 673655Fatty acyl-CoA synthetase BPRO_0000384439Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi267 – 2671N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiQ1ZXQ4.

Expressioni

Inductioni

Down-regulated by Pseudomonas aeruginosa, PAO1 strain and PA14 strain infection.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB_0231574.

Structurei

3D structure databases

ProteinModelPortaliQ1ZXQ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG1022.
InParanoidiQ1ZXQ4.
KOiK01897.
OMAiAVIAYTS.
PhylomeDBiQ1ZXQ4.

Family and domain databases

InterProiIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q1ZXQ4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MINNWLAVGL LVVSGILAFN WKRKHPYGQT VEIGEKPENG GRIRRNSACA
60 70 80 90 100
DHLISFLEDD EIYTLYDSLV KSCKKYGERK CFGERKKDSN GNLGKFEWIS
110 120 130 140 150
YNTYLERCEY IQQGLCELGL KPKSKVGIFS KNRLEWLIVH SASFIQSYCV
160 170 180 190 200
VSFYETLGVE SLSYVTEHAE IGLAFCSAET LQKTLDIAKG VKVLKTIICF
210 220 230 240 250
DSIDKEHYNI AKELGVTLYT YDEIMKKGKE ANGKHKHTPP TPDTLSTIMY
260 270 280 290 300
TSGTTGPPKG VMITHKNLTS VVCAVSDFIK VYDTDVHYSY LPYAHVLERV
310 320 330 340 350
VILAAFHFGA AIGIFSGDIS NILVEVKLLS PTLFIGVPRV FERIKTNVFK
360 370 380 390 400
EISKKPALLR TLFNGAYNLK YLSIQHGFKL PIIEKVLDLV FFSKIKQALG
410 420 430 440 450
GKVRVILSGS APLSFDTEVF LRVVMCCCVL QGYGASEGCG GDACKRLDDE
460 470 480 490 500
SVGTIGPPFA SNEIKLVDVP ELGYDSNGEV QTGEVCLRGP SISSGYYKDE
510 520 530 540 550
EKTREEFKDG WFHTGDIGRW NRDGSLSIVD RKKNIFKLSQ GEYVAVEKIE
560 570 580 590 600
TIVVKSEYVE QVCIYGDSQK SCVIAIIHPH PESCSEWAGS KKTDKDIKEI
610 620 630 640 650
CKNQDFIKVV LDDIIKNCKK SGLHGFEIPK AIHLTPEAFS DQNNLLTPSF
660 670
KLKRHEIKKY FEDEIKKLYS KLD
Length:673
Mass (Da):75,581
Last modified:May 2, 2006 - v1
Checksum:i6E1987AAB92B9D8D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000005 Genomic DNA. Translation: EAS66934.1.
RefSeqiXP_001134470.1. XM_001134470.1.

Genome annotation databases

EnsemblProtistsiDDB0231574; DDB0231574; DDB_G0269474.
GeneIDi8616941.
KEGGiddi:DDB_G0269474.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000005 Genomic DNA. Translation: EAS66934.1 .
RefSeqi XP_001134470.1. XM_001134470.1.

3D structure databases

ProteinModelPortali Q1ZXQ4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0231574.

Proteomic databases

PRIDEi Q1ZXQ4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0231574 ; DDB0231574 ; DDB_G0269474 .
GeneIDi 8616941.
KEGGi ddi:DDB_G0269474.

Organism-specific databases

dictyBasei DDB_G0269474. fcsB.

Phylogenomic databases

eggNOGi COG1022.
InParanoidi Q1ZXQ4.
KOi K01897.
OMAi AVIAYTS.
PhylomeDBi Q1ZXQ4.

Family and domain databases

InterProi IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
[Graphical view ]
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. "A Dictyostelium long chain fatty acyl coenzyme A-synthetase mediates fatty acid retrieval from endosomes."
    von Loehneysen K., Pawolleck N., Ruehling H., Maniak M.
    Eur. J. Cell Biol. 82:505-514(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  3. "Dictyostelium transcriptional responses to Pseudomonas aeruginosa: common and specific effects from PAO1 and PA14 strains."
    Carilla-Latorre S., Calvo-Garrido J., Bloomfield G., Skelton J., Kay R.R., Ivens A., Martinez J.L., Escalante R.
    BMC Microbiol. 8:109-109(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiFCSB_DICDI
AccessioniPrimary (citable) accession number: Q1ZXQ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 2, 2006
Last modified: October 1, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3