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Q1ZXQ4 (FCSB_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 47. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fatty acyl-CoA synthetase B

EC=6.2.1.3
Alternative name(s):
Long chain fatty acyl coenzyme A-synthetase 2
Short name=LC-FACS 2
Long-chain-fatty-acid--CoA synthetase 2
Gene names
Name:fcsB
ORF Names:DDB_G0269474
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length673 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Long chain fatty acid acyl-CoA synthetases catalyze the formation of a thiester bond between a free fatty acid and coenzyme A during fatty acid metabolic process By similarity.

Catalytic activity

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Subcellular location

Endoplasmic reticulum Ref.2.

Induction

Down-regulated by Pseudomonas aeruginosa, PAO1 strain and PA14 strain infection.

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 673655Fatty acyl-CoA synthetase B
PRO_0000384439

Amino acid modifications

Glycosylation2671N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q1ZXQ4 [UniParc].

Last modified May 2, 2006. Version 1.
Checksum: 6E1987AAB92B9D8D

FASTA67375,581
        10         20         30         40         50         60 
MINNWLAVGL LVVSGILAFN WKRKHPYGQT VEIGEKPENG GRIRRNSACA DHLISFLEDD 

        70         80         90        100        110        120 
EIYTLYDSLV KSCKKYGERK CFGERKKDSN GNLGKFEWIS YNTYLERCEY IQQGLCELGL 

       130        140        150        160        170        180 
KPKSKVGIFS KNRLEWLIVH SASFIQSYCV VSFYETLGVE SLSYVTEHAE IGLAFCSAET 

       190        200        210        220        230        240 
LQKTLDIAKG VKVLKTIICF DSIDKEHYNI AKELGVTLYT YDEIMKKGKE ANGKHKHTPP 

       250        260        270        280        290        300 
TPDTLSTIMY TSGTTGPPKG VMITHKNLTS VVCAVSDFIK VYDTDVHYSY LPYAHVLERV 

       310        320        330        340        350        360 
VILAAFHFGA AIGIFSGDIS NILVEVKLLS PTLFIGVPRV FERIKTNVFK EISKKPALLR 

       370        380        390        400        410        420 
TLFNGAYNLK YLSIQHGFKL PIIEKVLDLV FFSKIKQALG GKVRVILSGS APLSFDTEVF 

       430        440        450        460        470        480 
LRVVMCCCVL QGYGASEGCG GDACKRLDDE SVGTIGPPFA SNEIKLVDVP ELGYDSNGEV 

       490        500        510        520        530        540 
QTGEVCLRGP SISSGYYKDE EKTREEFKDG WFHTGDIGRW NRDGSLSIVD RKKNIFKLSQ 

       550        560        570        580        590        600 
GEYVAVEKIE TIVVKSEYVE QVCIYGDSQK SCVIAIIHPH PESCSEWAGS KKTDKDIKEI 

       610        620        630        640        650        660 
CKNQDFIKVV LDDIIKNCKK SGLHGFEIPK AIHLTPEAFS DQNNLLTPSF KLKRHEIKKY 

       670 
FEDEIKKLYS KLD 

« Hide

References

« Hide 'large scale' references
[1]"The genome of the social amoeba Dictyostelium discoideum."
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. expand/collapse author list , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.
[2]"A Dictyostelium long chain fatty acyl coenzyme A-synthetase mediates fatty acid retrieval from endosomes."
von Loehneysen K., Pawolleck N., Ruehling H., Maniak M.
Eur. J. Cell Biol. 82:505-514(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION.
[3]"Dictyostelium transcriptional responses to Pseudomonas aeruginosa: common and specific effects from PAO1 and PA14 strains."
Carilla-Latorre S., Calvo-Garrido J., Bloomfield G., Skelton J., Kay R.R., Ivens A., Martinez J.L., Escalante R.
BMC Microbiol. 8:109-109(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: INDUCTION [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000005 Genomic DNA. Translation: EAS66934.1.

3D structure databases

ProteinModelPortalQ1ZXQ4.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDB_0231574.

Proteomic databases

PRIDEQ1ZXQ4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0231574; DDB0231574; DDB_G0269474.
KEGGddi:DDB_G0269474.

Organism-specific databases

dictyBaseDDB_G0269474. fcsB.

Phylogenomic databases

eggNOGCOG1022.
InParanoidQ1ZXQ4.
KOK01897.
OMALSTIMYT.
PhylomeDBQ1ZXQ4.

Family and domain databases

InterProIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamPF00501. AMP-binding. 1 hit.
[Graphical view]
PROSITEPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFCSB_DICDI
AccessionPrimary (citable) accession number: Q1ZXQ4
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: May 2, 2006
Last modified: April 16, 2014
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase