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Q1ZXQ4

- FCSB_DICDI

UniProt

Q1ZXQ4 - FCSB_DICDI

Protein

Fatty acyl-CoA synthetase B

Gene

fcsB

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (02 May 2006)
      Previous versions | rss
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    Functioni

    Long chain fatty acid acyl-CoA synthetases catalyze the formation of a thiester bond between a free fatty acid and coenzyme A during fatty acid metabolic process.By similarity

    Catalytic activityi

    ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. long-chain fatty acid-CoA ligase activity Source: dictyBase

    GO - Biological processi

    1. fatty acid metabolic process Source: dictyBase
    2. long-chain fatty acid metabolic process Source: GOC
    3. positive regulation of phagocytosis Source: dictyBase

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Fatty acid metabolism, Lipid metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Fatty acyl-CoA synthetase B (EC:6.2.1.3)
    Alternative name(s):
    Long chain fatty acyl coenzyme A-synthetase 2
    Short name:
    LC-FACS 2
    Long-chain-fatty-acid--CoA synthetase 2
    Gene namesi
    Name:fcsB
    ORF Names:DDB_G0269474
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 1, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0269474. fcsB.

    Subcellular locationi

    Endoplasmic reticulum 1 Publication

    GO - Cellular componenti

    1. endoplasmic reticulum Source: dictyBase
    2. integral component of membrane Source: dictyBase
    3. peroxisome Source: dictyBase

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 673655Fatty acyl-CoA synthetase BPRO_0000384439Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi267 – 2671N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiQ1ZXQ4.

    Expressioni

    Inductioni

    Down-regulated by Pseudomonas aeruginosa, PAO1 strain and PA14 strain infection.1 Publication

    Interactioni

    Protein-protein interaction databases

    STRINGi44689.DDB_0231574.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1ZXQ4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG1022.
    InParanoidiQ1ZXQ4.
    KOiK01897.
    OMAiAVIAYTS.
    PhylomeDBiQ1ZXQ4.

    Family and domain databases

    InterProiIPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view]
    PfamiPF00501. AMP-binding. 1 hit.
    [Graphical view]
    PROSITEiPS00455. AMP_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q1ZXQ4-1 [UniParc]FASTAAdd to Basket

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    MINNWLAVGL LVVSGILAFN WKRKHPYGQT VEIGEKPENG GRIRRNSACA    50
    DHLISFLEDD EIYTLYDSLV KSCKKYGERK CFGERKKDSN GNLGKFEWIS 100
    YNTYLERCEY IQQGLCELGL KPKSKVGIFS KNRLEWLIVH SASFIQSYCV 150
    VSFYETLGVE SLSYVTEHAE IGLAFCSAET LQKTLDIAKG VKVLKTIICF 200
    DSIDKEHYNI AKELGVTLYT YDEIMKKGKE ANGKHKHTPP TPDTLSTIMY 250
    TSGTTGPPKG VMITHKNLTS VVCAVSDFIK VYDTDVHYSY LPYAHVLERV 300
    VILAAFHFGA AIGIFSGDIS NILVEVKLLS PTLFIGVPRV FERIKTNVFK 350
    EISKKPALLR TLFNGAYNLK YLSIQHGFKL PIIEKVLDLV FFSKIKQALG 400
    GKVRVILSGS APLSFDTEVF LRVVMCCCVL QGYGASEGCG GDACKRLDDE 450
    SVGTIGPPFA SNEIKLVDVP ELGYDSNGEV QTGEVCLRGP SISSGYYKDE 500
    EKTREEFKDG WFHTGDIGRW NRDGSLSIVD RKKNIFKLSQ GEYVAVEKIE 550
    TIVVKSEYVE QVCIYGDSQK SCVIAIIHPH PESCSEWAGS KKTDKDIKEI 600
    CKNQDFIKVV LDDIIKNCKK SGLHGFEIPK AIHLTPEAFS DQNNLLTPSF 650
    KLKRHEIKKY FEDEIKKLYS KLD 673
    Length:673
    Mass (Da):75,581
    Last modified:May 2, 2006 - v1
    Checksum:i6E1987AAB92B9D8D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000005 Genomic DNA. Translation: EAS66934.1.
    RefSeqiXP_001134470.1. XM_001134470.1.

    Genome annotation databases

    EnsemblProtistsiDDB0231574; DDB0231574; DDB_G0269474.
    GeneIDi8616941.
    KEGGiddi:DDB_G0269474.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000005 Genomic DNA. Translation: EAS66934.1 .
    RefSeqi XP_001134470.1. XM_001134470.1.

    3D structure databases

    ProteinModelPortali Q1ZXQ4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDB_0231574.

    Proteomic databases

    PRIDEi Q1ZXQ4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0231574 ; DDB0231574 ; DDB_G0269474 .
    GeneIDi 8616941.
    KEGGi ddi:DDB_G0269474.

    Organism-specific databases

    dictyBasei DDB_G0269474. fcsB.

    Phylogenomic databases

    eggNOGi COG1022.
    InParanoidi Q1ZXQ4.
    KOi K01897.
    OMAi AVIAYTS.
    PhylomeDBi Q1ZXQ4.

    Family and domain databases

    InterProi IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view ]
    Pfami PF00501. AMP-binding. 1 hit.
    [Graphical view ]
    PROSITEi PS00455. AMP_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.
    2. "A Dictyostelium long chain fatty acyl coenzyme A-synthetase mediates fatty acid retrieval from endosomes."
      von Loehneysen K., Pawolleck N., Ruehling H., Maniak M.
      Eur. J. Cell Biol. 82:505-514(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    3. "Dictyostelium transcriptional responses to Pseudomonas aeruginosa: common and specific effects from PAO1 and PA14 strains."
      Carilla-Latorre S., Calvo-Garrido J., Bloomfield G., Skelton J., Kay R.R., Ivens A., Martinez J.L., Escalante R.
      BMC Microbiol. 8:109-109(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INDUCTION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiFCSB_DICDI
    AccessioniPrimary (citable) accession number: Q1ZXQ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: May 2, 2006
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3