Q1ZXQ1 (FAAA_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Fumarylacetoacetase
Short name=FAA
EC=3.7.1.2

Alternative name(s):
Beta-diketonase
Fumarylacetoacetate hydrolase

Gene names

Name:	fah
ORF Names:	DDB_G0271094

Organism

Dictyostelium discoideum (Slime mold)

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	427 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	4-fumarylacetoacetate + H2O = acetoacetate + fumarate.
Cofactor	Calcium By similarity. Magnesium By similarity.
Pathway	Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 6/6.
Sequence similarities	Belongs to the FAH family.

Ontologies

Keywords
Biological process	Phenylalanine catabolism Tyrosine catabolism
Ligand	Calcium Magnesium Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	L-phenylalanine catabolic process Inferred from electronic annotation. Source: UniProtKB-KW tyrosine catabolic process Inferred from sequence or structural similarity. Source: dictyBase
Molecular function	fumarylacetoacetase activity Inferred from sequence or structural similarity. Source: dictyBase metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 427	427	Fumarylacetoacetase		PRO_0000318805
Sites
	Active site	137	1	Proton acceptor By similarity
	Metal binding	130	1	Calcium By similarity
	Metal binding	204	1	Calcium By similarity
	Metal binding	206	1	Calcium By similarity
	Metal binding	239	1	Calcium By similarity
	Metal binding	239	1	Magnesium By similarity
	Metal binding	259	1	Magnesium By similarity
	Metal binding	263	1	Magnesium By similarity
	Binding site	132	1	Substrate By similarity
	Binding site	146	1	Substrate By similarity
	Binding site	246	1	Substrate By similarity
	Binding site	250	1	Substrate By similarity
	Binding site	356	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1ZXQ1 [UniParc]. Last modified May 2, 2006. Version 1. Checksum: 7A83720EFB17516A	FASTA	427	47,429
	10 20 30 40 50 60 MSILKSFIEV SEDSHFPIQN LPYGVFKPTL NDQARIGVAI GDFVCDLSVL ADLKLFDGKL 70 80 90 100 110 120 KDTKVFHQEN LNSFMSLGKE LWSEARKTIQ NLLSSETSTI RDNKEYREKI FHSISSVTML 130 140 150 160 170 180 LPARIGDYTD FYASKEHATN VGIMFRGKEN ALMPNWVHLP VGYHGRSSSI VVSGTPLKRP 190 200 210 220 230 240 WGQTKSDEPD SLPTFNPCRL LDFELEMGAL IGGESTKLGE PISIESAKDH IFGLVLLNDW 250 260 270 280 290 300 SARDIQKWEY VPLGPFLAKN FGSTISPWVV TMEALQPFAT KPPTQDPQPM KYLQEQGNTT 310 320 330 340 350 360 FDIELSVSIK SPKMSKPHKV STSNLKYMYW TLTQQLAHHT VNGCNMNAGD LLGTGTISGP 370 380 390 400 410 420 TEDSYGSMLE LSWKGSKVVS LGTETNEERK FIQDGDSVIL SGLCKGNGYQ IGFGNCEGTI LPADKRQ

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000005 Genomic DNA. Translation: EAS66937.1.
RefSeq	XP_001134473.1. XM_001134473.1.
3D structure databases
ProteinModelPortal	Q1ZXQ1.
SMR	Q1ZXQ1. Positions 6-423.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1ZXQ1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0231609; DDB0231609; DDB_G0271094.
GeneID	8617161.
GenomeReviews	Gene locus fah in contig CM000150_GR.
KEGG	ddi:DDB_G0271094.
Organism-specific databases
dictyBase	DDB_G0271094. fah.
Phylogenomic databases
eggNOG	KOG2843.
GeneTree	EPrGT00050000005672.
HOGENOM	HBG289935.
OMA	HSVNGCN.
ProtClustDB	CLSZ2445170.
Family and domain databases
InterPro	IPR005959. Fumarylacetoacetase. IPR002529. Fumarylacetoacetase_C. IPR011234. Fumarylacetoacetase_C-rel. IPR015377. Fumarylacetoacetase_N. [Graphical view]
Gene3D	G3DSA:3.90.850.10. Fumarylacetoacetase_C-rel. 1 hit. G3DSA:2.30.30.230. Fumarylacetoacetase_N. 1 hit.
KO	K01555.
PANTHER	PTHR11820:SF1. Fum_ac_acetase. 1 hit.
Pfam	PF09298. DUF1969. 1 hit. PF01557. FAA_hydrolase. 1 hit. [Graphical view]
SUPFAM	SSF56529. Fumarylacetoacetase_C-rel. 1 hit. SSF63433. Fumarylacetoacetase_N. 1 hit.
TIGRFAMs	TIGR01266. Fum_ac_acetase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

FAAA_DICDI

Accession

Primary (citable) accession number: Q1ZXQ1

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
Last sequence update:	May 2, 2006
Last modified:	November 16, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)