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Protein

Fumarylacetoacetase

Gene

fah

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

4-fumarylacetoacetate + H2O = acetoacetate + fumarate.By similarity

Cofactori

Protein has several cofactor binding sites:
  • Ca2+By similarity
  • Mg2+By similarity

Pathwayi: L-phenylalanine degradation

This protein is involved in step 6 of the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine.
Proteins known to be involved in the 6 steps of the subpathway in this organism are:
  1. Phenylalanine-4-hydroxylase (pah)
  2. Tyrosine aminotransferase (tat)
  3. 4-hydroxyphenylpyruvate dioxygenase (hpd)
  4. Homogentisate 1,2-dioxygenase (hgd)
  5. Maleylacetoacetate isomerase (mai)
  6. Fumarylacetoacetase (fah)
This subpathway is part of the pathway L-phenylalanine degradation, which is itself part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetoacetate and fumarate from L-phenylalanine, the pathway L-phenylalanine degradation and in Amino-acid degradation.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi130 – 1301CalciumBy similarity
Binding sitei132 – 1321SubstrateBy similarity
Active sitei137 – 1371Proton acceptorBy similarity
Binding sitei146 – 1461SubstrateBy similarity
Metal bindingi204 – 2041CalciumBy similarity
Metal bindingi206 – 2061CalciumBy similarity
Metal bindingi239 – 2391CalciumBy similarity
Metal bindingi239 – 2391MagnesiumBy similarity
Binding sitei246 – 2461SubstrateBy similarity
Binding sitei250 – 2501SubstrateBy similarity
Metal bindingi259 – 2591MagnesiumBy similarity
Metal bindingi263 – 2631MagnesiumBy similarity
Binding sitei356 – 3561SubstrateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Phenylalanine catabolism, Tyrosine catabolism

Keywords - Ligandi

Calcium, Magnesium, Metal-binding

Enzyme and pathway databases

ReactomeiR-DDI-71182. Phenylalanine and tyrosine catabolism.
UniPathwayiUPA00139; UER00341.

Names & Taxonomyi

Protein namesi
Recommended name:
Fumarylacetoacetase (EC:3.7.1.2By similarity)
Short name:
FAA
Alternative name(s):
Beta-diketonase
Fumarylacetoacetate hydrolase
Gene namesi
Name:fah
ORF Names:DDB_G0271094
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 1, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0271094. fah.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 427427FumarylacetoacetasePRO_0000318805Add
BLAST

Proteomic databases

PaxDbiQ1ZXQ1.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0231609.

Structurei

3D structure databases

ProteinModelPortaliQ1ZXQ1.
SMRiQ1ZXQ1. Positions 6-423.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAH family.Curated

Phylogenomic databases

eggNOGiKOG2843. Eukaryota.
COG0179. LUCA.
InParanoidiQ1ZXQ1.
KOiK01555.
OMAiLPNWLHI.
PhylomeDBiQ1ZXQ1.

Family and domain databases

Gene3Di2.30.30.230. 1 hit.
3.90.850.10. 1 hit.
InterProiIPR005959. Fumarylacetoacetase.
IPR011234. Fumarylacetoacetase_C-rel.
IPR015377. Fumarylacetoacetase_N.
[Graphical view]
PANTHERiPTHR11820:SF1. PTHR11820:SF1. 2 hits.
PfamiPF01557. FAA_hydrolase. 1 hit.
PF09298. FAA_hydrolase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56529. SSF56529. 1 hit.
SSF63433. SSF63433. 1 hit.
TIGRFAMsiTIGR01266. fum_ac_acetase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1ZXQ1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSILKSFIEV SEDSHFPIQN LPYGVFKPTL NDQARIGVAI GDFVCDLSVL
60 70 80 90 100
ADLKLFDGKL KDTKVFHQEN LNSFMSLGKE LWSEARKTIQ NLLSSETSTI
110 120 130 140 150
RDNKEYREKI FHSISSVTML LPARIGDYTD FYASKEHATN VGIMFRGKEN
160 170 180 190 200
ALMPNWVHLP VGYHGRSSSI VVSGTPLKRP WGQTKSDEPD SLPTFNPCRL
210 220 230 240 250
LDFELEMGAL IGGESTKLGE PISIESAKDH IFGLVLLNDW SARDIQKWEY
260 270 280 290 300
VPLGPFLAKN FGSTISPWVV TMEALQPFAT KPPTQDPQPM KYLQEQGNTT
310 320 330 340 350
FDIELSVSIK SPKMSKPHKV STSNLKYMYW TLTQQLAHHT VNGCNMNAGD
360 370 380 390 400
LLGTGTISGP TEDSYGSMLE LSWKGSKVVS LGTETNEERK FIQDGDSVIL
410 420
SGLCKGNGYQ IGFGNCEGTI LPADKRQ
Length:427
Mass (Da):47,429
Last modified:May 2, 2006 - v1
Checksum:i7A83720EFB17516A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000005 Genomic DNA. Translation: EAS66937.1.
RefSeqiXP_001134473.1. XM_001134473.1.

Genome annotation databases

EnsemblProtistsiDDB0231609; DDB0231609; DDB_G0271094.
GeneIDi8617161.
KEGGiddi:DDB_G0271094.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000005 Genomic DNA. Translation: EAS66937.1.
RefSeqiXP_001134473.1. XM_001134473.1.

3D structure databases

ProteinModelPortaliQ1ZXQ1.
SMRiQ1ZXQ1. Positions 6-423.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0231609.

Proteomic databases

PaxDbiQ1ZXQ1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0231609; DDB0231609; DDB_G0271094.
GeneIDi8617161.
KEGGiddi:DDB_G0271094.

Organism-specific databases

dictyBaseiDDB_G0271094. fah.

Phylogenomic databases

eggNOGiKOG2843. Eukaryota.
COG0179. LUCA.
InParanoidiQ1ZXQ1.
KOiK01555.
OMAiLPNWLHI.
PhylomeDBiQ1ZXQ1.

Enzyme and pathway databases

UniPathwayiUPA00139; UER00341.
ReactomeiR-DDI-71182. Phenylalanine and tyrosine catabolism.

Miscellaneous databases

PROiQ1ZXQ1.

Family and domain databases

Gene3Di2.30.30.230. 1 hit.
3.90.850.10. 1 hit.
InterProiIPR005959. Fumarylacetoacetase.
IPR011234. Fumarylacetoacetase_C-rel.
IPR015377. Fumarylacetoacetase_N.
[Graphical view]
PANTHERiPTHR11820:SF1. PTHR11820:SF1. 2 hits.
PfamiPF01557. FAA_hydrolase. 1 hit.
PF09298. FAA_hydrolase_N. 1 hit.
[Graphical view]
SUPFAMiSSF56529. SSF56529. 1 hit.
SSF63433. SSF63433. 1 hit.
TIGRFAMsiTIGR01266. fum_ac_acetase. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiFAAA_DICDI
AccessioniPrimary (citable) accession number: Q1ZXQ1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 2, 2006
Last modified: December 9, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.