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Protein

Frizzled and smoothened-like protein O

Gene

fslO

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Keywordsi

Molecular functionReceptor

Names & Taxonomyi

Protein namesi
Recommended name:
Frizzled and smoothened-like protein O
Gene namesi
Name:fslO
ORF Names:DDB_G0278289
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0278289. fslO.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 233ExtracellularSequence analysisAdd BLAST210
Transmembranei234 – 254Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini255 – 262CytoplasmicSequence analysis8
Transmembranei263 – 283Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini284 – 307ExtracellularSequence analysisAdd BLAST24
Transmembranei308 – 328Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini329 – 343CytoplasmicSequence analysisAdd BLAST15
Transmembranei344 – 364Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini365 – 387ExtracellularSequence analysisAdd BLAST23
Transmembranei388 – 408Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini409 – 435CytoplasmicSequence analysisAdd BLAST27
Transmembranei436 – 456Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini457 – 500ExtracellularSequence analysisAdd BLAST44
Transmembranei501 – 521Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini522 – 695CytoplasmicSequence analysisAdd BLAST174

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000037137624 – 695Frizzled and smoothened-like protein OAdd BLAST672

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 96PROSITE-ProRule annotation
Disulfide bondi42 ↔ 89PROSITE-ProRule annotation
Glycosylationi47N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi80 ↔ 125PROSITE-ProRule annotation
Disulfide bondi114 ↔ 170PROSITE-ProRule annotation
Disulfide bondi118 ↔ 138PROSITE-ProRule annotation
Glycosylationi137N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi178N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ1ZXI9.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0231534.

Structurei

3D structure databases

ProteinModelPortaliQ1ZXI9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 173FZPROSITE-ProRule annotationAdd BLAST146

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili653 – 691Sequence analysisAdd BLAST39

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi626 – 672Poly-AsnAdd BLAST47
Compositional biasi675 – 686Poly-AsnAdd BLAST12

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ1ZXI9.
PhylomeDBiQ1ZXI9.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiView protein in InterPro
IPR020067. Frizzled_dom.
IPR036790. Frizzled_dom_sf.
PfamiView protein in Pfam
PF01392. Fz. 1 hit.
SUPFAMiSSF63501. SSF63501. 1 hit.
PROSITEiView protein in PROSITE
PS50038. FZ. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q1ZXI9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKLNYLLIV SFIFILNLLI SKSQVLIDVT AKCELIDSLS PCKDNLNYTH
60 70 80 90 100
IYLPTGYTQA AISAQITPLF QQASILPTDC QSNLKNLLCI SSYMECNENI
110 120 130 140 150
PNISPSFPLP SYPCNKYCEK VKDVCSAYMA ILGPYVNCSA VQNGNEFFPH
160 170 180 190 200
TGTDYDLTAY GGSANEEIQC SGPNLASNST SAPIKFCPSP LIWVDSDTIN
210 220 230 240 250
NKRAYQETTP NCVLPCPTNV YTEKEYKTKF YSEAILFSFS TACSFYLIFT
260 270 280 290 300
FGVFPNKYTN RNWIIVYLGI TAICLAISYA VQEARYGGGD WRCTSDPGRY
310 320 330 340 350
KSSEDGTCIL GGFFFQIGGL GTILFLSLYS FDMFLTMNMM TNKYFIQTSV
360 370 380 390 400
GMWALIIFYA LLPIKHYESS IASAGCWLSN EDNMFWQYFC FYVPSYVATF
410 420 430 440 450
FLGVFIITSI YKVFKMTVMF KSIKDKRILL LNIRSIIFLI AIMFCVSFST
460 470 480 490 500
MYPLYVTYNG DDFSKSVEVY VTCLYANIPN GNEVCPQIVF PQFSLRYMNA
510 520 530 540 550
ITMAIIGIVG LIGLGIDPHI LQIYRESIRF KFLLGLVGIQ WGTNSPQPLK
560 570 580 590 600
QGSTTDSSSG SGSGNGSNSG NNRENRKSQR KSRGVSIGMK KINLSASSES
610 620 630 640 650
SNNLLNQSTP GNLNINESIS SIDTSNNNNN NNNNNNNNNN NNNNNNNNNN
660 670 680 690
NNNNNNNNNN NNNNNNNNNN NNYSNNNNNN NNNNNNIERI NSDNV
Length:695
Mass (Da):77,709
Last modified:May 2, 2006 - v1
Checksum:iA603D1A96B69EC69
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000023 Genomic DNA. Translation: EAS66898.1.
RefSeqiXP_001134582.1. XM_001134582.1.

Genome annotation databases

EnsemblProtistsiEAS66898; EAS66898; DDB_G0278289.
GeneIDi8621475.
KEGGiddi:DDB_G0278289.

Similar proteinsi

Entry informationi

Entry nameiFSLO_DICDI
AccessioniPrimary (citable) accession number: Q1ZXI9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 2, 2006
Last modified: October 25, 2017
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  3. SIMILARITY comments
    Index of protein domains and families