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Q1ZXI8 (MANE_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alpha-mannosidase E

EC=3.2.1.24
Gene names
Name:manE
ORF Names:DDB_G0278651
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length1123 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides.

Cofactor

Binds 1 zinc ion per subunit By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Sequence similarities

Belongs to the glycosyl hydrolase 38 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 11231102Alpha-mannosidase E
PRO_0000327844

Regions

Topological domain22 – 10721051Extracellular Potential
Transmembrane1073 – 109321Helical; Potential
Topological domain1094 – 112330Cytoplasmic Potential
Compositional bias451 – 4566Poly-Asn
Compositional bias1020 – 10234Poly-Asn

Sites

Active site1501Nucleophile By similarity
Metal binding671Zinc By similarity
Metal binding691Zinc By similarity
Metal binding1501Zinc By similarity
Metal binding4091Zinc By similarity

Amino acid modifications

Glycosylation21N-linked (GlcNAc...) Potential
Glycosylation381N-linked (GlcNAc...) Potential
Glycosylation1401N-linked (GlcNAc...) Potential
Glycosylation5211N-linked (GlcNAc...) Potential
Glycosylation6751N-linked (GlcNAc...) Potential
Glycosylation8581N-linked (GlcNAc...) Potential
Glycosylation8871N-linked (GlcNAc...) Potential
Glycosylation9751N-linked (GlcNAc...) Potential
Glycosylation9901N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q1ZXI8 [UniParc].

Last modified May 2, 2006. Version 1.
Checksum: 7EAB06BD0CC3966C

FASTA1,123129,935
        10         20         30         40         50         60 
MNKTKLIKII FVIGVWILLS TFIINIYNEN FEIVNYNNNS QSLKKIFQLN GDLKDEKLSI 

        70         80         90        100        110        120 
FLIPHSHCDS GWLQDYDWYY NHVVQYILSG IVNELNLDKE KKFNWVEIGG WVQNDEATAT 

       130        140        150        160        170        180 
IDDVITQMTQ GHQWLKDTLN YTIEYAWQID PFGYSSSTPT IFSSMGIKGL IINRVSDDVK 

       190        200        210        220        230        240 
SYMKSAKEME FIWKGSESLG EQSQMLVSTL NVHYDYPKHI DPKKDFSLEE RVKGFTKYIK 

       250        260        270        280        290        300 
DLSNTRESSI LMIPLGDDFR YSNAKNEFSV SKEWLKVIQD NKEKYNIKEI KYATIDEYFI 

       310        320        330        340        350        360 
ALEDEFMNKL GKTVEENLKT GFSSTLSLYN KDFFPYSTGD LEYWTGYYTT RPLLKRLIRE 

       370        380        390        400        410        420 
SSLLQKSSDI LYTLAIGENS NNQIDINNLQ TLSNQLNENR NTIALVQHHD IVTGTSRSFV 

       430        440        450        460        470        480 
LNDNFQRLQK SRISNYNIIS NSLEYLLNKD NNNNENTDST NEPFNFENVI DLSNEINNQY 

       490        500        510        520        530        540 
SLVFHNTLGW EVNQHVSFRI KVNKNDNQLL ESIQLVEAIS NKTIQIQIIP IQDDSNCQSI 

       550        560        570        580        590        600 
ENNYIVFAII NLPPLGLNTY YLSISSNEDS KPNTILSKPK LLKKGNEINF NNNRFKVEFE 

       610        620        630        640        650        660 
SNGLISKITD KNSNEIKTIE QTFHQYSTKK SGPYIFNVKG GKKHGFLENP DKFIYHDGPL 

       670        680        690        700        710        720 
VSQLTMLYGV DDGCNVTSIV VQRIYKNNEI DNSNSKSLIT ENYIETGYSI NGDMNRETTI 

       730        740        750        760        770        780 
NYKVKDLEND DIFYTDNGLE SRKRIYNHDR TVNQNYYPVL GYIKLKETSE NNNHQYTVYV 

       790        800        810        820        830        840 
DRSVGATSPS DGEMEIMIHR TMDTDDWKGV NWPSKDIGRS DAKLYFNMDL VNNQLQNEKR 

       850        860        870        880        890        900 
ISLHITNQPI MFVKKHNNQT GYLLKYSPLS NQLPSNIHLQ SLLTLKNNTV GLRLFNIHEV 

       910        920        930        940        950        960 
DSNTQSTTDT DKSTLFNELE ISNFIETGLS FLKLTKNNLI DKYSTRINKK FPVKCGESEY 

       970        980        990       1000       1010       1020 
SFINEKPSSI IFSNNGTNNI IDGENKGENN KTIETIQIKP HEIKSFTFNF NFQLDQIIPN 

      1030       1040       1050       1060       1070       1080 
NNNYAINKEL NNEYIEQSIE NQRYEYDFSF FPIKPTFYDD RGKYNRPNHL ALILSLSIGT 

      1090       1100       1110       1120 
PAGILIIVIA LVVIYKKRKN RKTLTSSYSL LNLILKDRAD SSP 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000023 Genomic DNA. Translation: EAS66899.1.

3D structure databases

ProteinModelPortalQ1ZXI8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDB_0231615.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0231615; DDB0231615; DDB_G0278651.
KEGGddi:DDB_G0278651.

Organism-specific databases

dictyBaseDDB_G0278651. manE.

Phylogenomic databases

eggNOGCOG0383.
OMATRESSIL.
PhylomeDBQ1ZXI8.
ProtClustDBCLSZ2430771.

Family and domain databases

Gene3D1.20.1270.50. 1 hit.
2.60.40.1180. 1 hit.
3.20.110.10. 2 hits.
InterProIPR011013. Gal_mutarotase_SF_dom.
IPR011330. Glyco_hydro/deAcase_b/a-brl.
IPR013780. Glyco_hydro_13_b.
IPR027291. Glyco_hydro_38/57_N.
IPR015341. Glyco_hydro_38_cen.
IPR000602. Glyco_hydro_38_N.
[Graphical view]
PfamPF09261. Alpha-mann_mid. 1 hit.
PF01074. Glyco_hydro_38. 2 hits.
[Graphical view]
SMARTSM00872. Alpha-mann_mid. 1 hit.
[Graphical view]
SUPFAMSSF74650. SSF74650. 2 hits.
SSF88713. SSF88713. 1 hit.
ProtoNetSearch...

Entry information

Entry nameMANE_DICDI
AccessionPrimary (citable) accession number: Q1ZXI8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 2, 2006
Last modified: April 16, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase