ID   D1060_DICDI             Reviewed;         166 AA.
AC   Q1ZXG8; O15745;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2006, sequence version 1.
DT   27-MAR-2024, entry version 80.
DE   RecName: Full=Probable tyrosine-protein phosphatase DG1060;
DE            EC=3.1.3.48;
DE   AltName: Full=Developmental gene 1060 protein;
GN   Name=DG1060; ORFNames=DDB_G0281953;
OS   Dictyostelium discoideum (Social amoeba).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-46.
RC   STRAIN=AX4;
RA   Loomis W.F., Iranfar N.;
RL   Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC         phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC         COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC         ChEBI:CHEBI:82620; EC=3.1.3.48;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000044; EAS66873.1; -; Genomic_DNA.
DR   EMBL; AF020278; AAB70846.1; -; Genomic_DNA.
DR   RefSeq; XP_001134556.1; XM_001134556.1.
DR   AlphaFoldDB; Q1ZXG8; -.
DR   SMR; Q1ZXG8; -.
DR   STRING; 44689.Q1ZXG8; -.
DR   PaxDb; 44689-DDB0232939; -.
DR   EnsemblProtists; EAS66873; EAS66873; DDB_G0281953.
DR   GeneID; 8623336; -.
DR   KEGG; ddi:DDB_G0281953; -.
DR   dictyBase; DDB_G0281953; -.
DR   eggNOG; KOG1572; Eukaryota.
DR   HOGENOM; CLU_047845_5_1_1; -.
DR   InParanoid; Q1ZXG8; -.
DR   OMA; MAHHIPP; -.
DR   PhylomeDB; Q1ZXG8; -.
DR   PRO; PR:Q1ZXG8; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0016791; F:phosphatase activity; IBA:GO_Central.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR   CDD; cd14531; PFA-DSP_Oca1; 1.
DR   Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR   InterPro; IPR020428; PFA-DSPs.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR004861; Siw14-like.
DR   InterPro; IPR020422; TYR_PHOSPHATASE_DUAL_dom.
DR   PANTHER; PTHR31126; TYROSINE-PROTEIN PHOSPHATASE; 1.
DR   PANTHER; PTHR31126:SF8; TYROSINE-PROTEIN PHOSPHATASE OCA1-RELATED; 1.
DR   Pfam; PF03162; Y_phosphatase2; 1.
DR   PRINTS; PR01911; PFDSPHPHTASE.
DR   SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR   PROSITE; PS50054; TYR_PHOSPHATASE_DUAL; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Hydrolase; Protein phosphatase; Reference proteome.
FT   CHAIN           1..166
FT                   /note="Probable tyrosine-protein phosphatase DG1060"
FT                   /id="PRO_0000368208"
FT   DOMAIN          9..162
FT                   /note="Tyrosine-protein phosphatase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00160"
FT   ACT_SITE        101
FT                   /note="Phosphocysteine intermediate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00160"
SQ   SEQUENCE   166 AA;  19380 MW;  632F2F84E8D17050 CRC64;
     MAHHIPPLNF GMVADDLYRS GQPNELNFPF LEKLQLKKII FLAPDDPSQQ FQNFVEDQDI
     ELIHLGMDTH QNPWNPISEE IVISALKIIL NPDNYPLHIM CNLGRHRTGT VVGCLRKLQR
     WNLTSIFEEY RRFAGSKVKL LNEQFIELFD TDLVTYNNAP QWLYLS
//