Q1ZXG8 (D1060_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable tyrosine-protein phosphatase DG1060
EC=3.1.3.48

Alternative name(s):
Developmental gene 1060 protein

Gene names

Name:	DG1060
ORF Names:	DDB_G0281953

Organism

Dictyostelium discoideum (Slime mold) [Reference proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	166 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase Protein phosphatase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	peptidyl-tyrosine dephosphorylation Inferred from electronic annotation. Source: GOC
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 166	166	Probable tyrosine-protein phosphatase DG1060		PRO_0000368208
Sites
	Active site	101	1	Phosphocysteine intermediate Potential

Sequences

	Sequence		Length	Mass (Da)
	Q1ZXG8 [UniParc]. Last modified May 2, 2006. Version 1. Checksum: 632F2F84E8D17050	FASTA	166	19,380
	10 20 30 40 50 60 MAHHIPPLNF GMVADDLYRS GQPNELNFPF LEKLQLKKII FLAPDDPSQQ FQNFVEDQDI 70 80 90 100 110 120 ELIHLGMDTH QNPWNPISEE IVISALKIIL NPDNYPLHIM CNLGRHRTGT VVGCLRKLQR 130 140 150 160 WNLTSIFEEY RRFAGSKVKL LNEQFIELFD TDLVTYNNAP QWLYLS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
[2]	Loomis W.F., Iranfar N. Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-46. Strain: AX4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000044 Genomic DNA. Translation: EAS66873.1. AF020278 Genomic DNA. Translation: AAB70846.1.
RefSeq	XP_001134556.1. XM_001134556.1.
3D structure databases
ProteinModelPortal	Q1ZXG8.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0232939; DDB0232939; DDB_G0281953.
GeneID	8623336.
KEGG	ddi:DDB_G0281953.
Organism-specific databases
dictyBase	DDB_G0281953.
Phylogenomic databases
eggNOG	COG2365.
InParanoid	Q1ZXG8.
OMA	KLQRWNL.
ProtClustDB	CLSZ2733545.
Family and domain databases
InterPro	IPR020428. Tyr_Pase_dualsp-Pase_euk. IPR004861. Tyr_Pase_SIW14-like. [Graphical view]
Pfam	PF03162. Y_phosphatase2. 1 hit. [Graphical view]
PRINTS	PR01911. PFDSPHPHTASE.
PROSITE	PS00383. TYR_PHOSPHATASE_1. False negative. PS50056. TYR_PHOSPHATASE_2. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

D1060_DICDI

Accession

Primary (citable) accession number: Q1ZXG8
Secondary accession number(s): O15745

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	May 2, 2006
Last modified:	May 1, 2013
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)