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Reviewed, UniProtKB/Swiss-Prot Q1ZXF7 (GMDS_DICDI)

Last modified February 9, 2010. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    GDP-mannose 4,6 dehydratase
    EC=4.2.1.47
Alternative name(s):
    GDP-D-mannose dehydratase
      Short name=GMD
Gene names
Name: gmd
ORF Names: DDB_G0284553
OrganismDictyostelium discoideum (Slime mold) [Complete proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length356 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Conversion of GDP-D-mannose to GDP-4-keto-6-D-deoxymannose.

Catalytic activity

GDP-mannose = GDP-4-dehydro-6-deoxy-D-mannose + H2O.

Cofactor

NADP By similarity.

Pathway

Nucleotide-sugar biosynthesis; GDP-L-fucose biosynthesis via de novo pathway; GDP-L-fucose from GDP-alpha-D-mannose: step 1/2.

Sequence similarities

Belongs to the GDP-mannose 4,6-dehydratase family.

Ontologies

Keywords
   LigandNADP
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processGDP-mannose metabolic process

Inferred from electronic annotation. Source: InterPro

   Cellular componentintracellular

Inferred from electronic annotation. Source: InterPro

   Molecular functionGDP-mannose 4,6-dehydratase activity

Inferred from electronic annotation. Source: EC

coenzyme binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 356356GDP-mannose 4,6 dehydratase
PRO_0000327628

Sites

Active site1381 By similarity
Active site1401Nucleophile By similarity
Active site1621Nucleophile By similarity
Binding site1661NADP By similarity

Natural variations

Natural variant1081G → D in strain: HL250; loss of activity.

Sequences

Sequence LengthMass (Da)Tools
Q1ZXF7-1 [UniParc].

Last modified May 2, 2006. Version 1.
Checksum: 9DB1B513B28E16CA

FASTA35641,061
        10         20         30         40         50         60 
MSEERKVALI TGITGQDGSY LTEFLISKGY YVHGIIQKIF HHFNTIVKNI YIKIDMLKEK 

        70         80         90        100        110        120 
ESLTLHYGDL TDASNLHSIV SKVNPTEIYN LGAQSHVKVS FDMSEYTGDV DGLGCLRLLD 

       130        140        150        160        170        180 
AIRSCGMEKK VKYYQASTSE LYGKVQEIPQ SETTPFYPRS PYAVAKQYAY WIVVNYREAY 

       190        200        210        220        230        240 
DMYACNGILF NHESPRRGPT FVTRKITRFV AGIACGRDEI LYLGNINAKR DWGHARDYVE 

       250        260        270        280        290        300 
AMWLMLQQEK PEDFVIATGE THSVREFVEK SFKEIDIIIK WRGEAEKEEG YCEKTGKVYV 

       310        320        330        340        350 
KIDEKYYRPT EVDLLLGNPN KAKKLLQWQI KTSFGELVKE MVAKDIEYIK NGDKYN 

« Hide

References

« Hide 'large scale' references
[1]"Development of Dictyostelium discoideum is associated with alteration of fucosylated N-glycan structures."
Schiller B., Hykollari A., Voglmeir J., Poltl G., Hummel K., Razzazi-Fazeli E., Geyer R., Wilson I.B.H.
Biochem. J. 423:41-52(2009) [PubMed: 19614564] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], IDENTIFICATION.
Strain: HL250.
[2]"The genome of the social amoeba Dictyostelium discoideum."
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. expand/collapse author list , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
Nature 435:43-57(2005) [PubMed: 15875012] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000066 Genomic DNA. Translation: EAS66860.1.
RefSeqXP_001134543.1.

3D structure databases

SMRQ1ZXF7. Positions 5-350.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ1ZXF7.

Genome annotation databases

GeneID8624624.
KEGGddi:DDB_0231676.

Organism-specific databases

dictyBaseDDB_G0284553. gmd.

Phylogenomic databases

eggNOGKOG1372.
HOGENOMHBG755066.
OMATQRVDHI.
PhylomeDBQ1ZXF7.

Enzyme and pathway databases

BRENDA4.2.1.47. 424.

Family and domain databases

InterProIPR001509. Epimerase_deHydtase.
IPR006368. GDP_Man_deHydtase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHERPTHR10366:SF32. GDP_mann_dehyd. 1 hit.
PfamPF01370. Epimerase. 1 hit.
[Graphical view]
TIGRFAMsTIGR01472. gmd. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGMDS_DICDI
AccessionPrimary (citable) accession number: Q1ZXF7
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 2, 2006
Last modified: February 9, 2010
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents