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Protein

Probable enoyl-CoA hydratase, mitochondrial

Gene

echs1

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Straight-chain enoyl-CoA thioesters from C4 up to at least C16 are processed, although with decreasing catalytic rate.By similarity

Catalytic activityi

(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O.

Pathwayi: fatty acid beta-oxidation

This protein is involved in the pathway fatty acid beta-oxidation, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid beta-oxidation and in Lipid metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei128 – 1281Substrate; via amide nitrogenBy similarity
Sitei151 – 1511Important for catalytic activityBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Enzyme and pathway databases

ReactomeiR-DDI-77310. Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA.
R-DDI-77346. Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA.
R-DDI-77348. Beta oxidation of octanoyl-CoA to hexanoyl-CoA.
R-DDI-77350. Beta oxidation of hexanoyl-CoA to butanoyl-CoA.
R-DDI-77352. Beta oxidation of butanoyl-CoA to acetyl-CoA.
UniPathwayiUPA00659.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable enoyl-CoA hydratase, mitochondrial (EC:4.2.1.17)
Alternative name(s):
Enoyl-CoA hydratase 1
Short-chain enoyl-CoA hydratase
Short name:
SCEH
Gene namesi
Name:echs1
ORF Names:DDB_G0285071
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 4, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0285071. echs1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4242MitochondrionAdd
BLAST
Chaini43 – 277235Probable enoyl-CoA hydratase, mitochondrialPRO_0000331592Add
BLAST

Proteomic databases

PaxDbiQ1ZXF1.
PRIDEiQ1ZXF1.

Interactioni

Subunit structurei

Homohexamer; dimer of trimers.By similarity

Protein-protein interaction databases

STRINGi44689.DDB0232942.

Structurei

3D structure databases

ProteinModelPortaliQ1ZXF1.
SMRiQ1ZXF1. Positions 28-270.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni85 – 884Substrate bindingBy similarity

Domaini

The monomer is folded into a right-handed spiral of four turns, followed by two small domains which are involved in trimerization.By similarity

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG1680. Eukaryota.
COG1024. LUCA.
InParanoidiQ1ZXF1.
KOiK07511.
OMAiVSKIYPV.
PhylomeDBiQ1ZXF1.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
InterProiIPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
IPR018376. Enoyl-CoA_hyd/isom_CS.
[Graphical view]
PfamiPF00378. ECH_1. 1 hit.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 1 hit.
PROSITEiPS00166. ENOYL_COA_HYDRATASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q1ZXF1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKQVIKTVS SSQAPKKYFF KQFCTSTTEK KGRVGLVTLN RPKSLNALSD
60 70 80 90 100
GLISEINSAV KLFQEDKDVG SIIITGSEKA FAAGADIKEM EKVTLPDAYN
110 120 130 140 150
NDLLAQWHDL TKIRKPIIAA VNGYALGGGC ELAMMCDIII AGEKAVFGQP
160 170 180 190 200
EIKLGTIPGC GGTQRLIRAI GKSKAMELVL TGNNLTAVEA EKAGLVSKVV
210 220 230 240 250
PVEELLTEAT KMAEKIASYS QLTVAMAKEA VNASYELTLQ EGIRFERRMF
260 270
HSTFGTHDQK EGMNAFVEKR TPTWHNK
Length:277
Mass (Da):30,187
Last modified:May 2, 2006 - v1
Checksum:i69C207F4D78F792B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000073 Genomic DNA. Translation: EAS66856.1.
RefSeqiXP_001134539.1. XM_001134539.1.

Genome annotation databases

EnsemblProtistsiDDB0232942; DDB0232942; DDB_G0285071.
GeneIDi8624884.
KEGGiddi:DDB_G0285071.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000073 Genomic DNA. Translation: EAS66856.1.
RefSeqiXP_001134539.1. XM_001134539.1.

3D structure databases

ProteinModelPortaliQ1ZXF1.
SMRiQ1ZXF1. Positions 28-270.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0232942.

Proteomic databases

PaxDbiQ1ZXF1.
PRIDEiQ1ZXF1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0232942; DDB0232942; DDB_G0285071.
GeneIDi8624884.
KEGGiddi:DDB_G0285071.

Organism-specific databases

dictyBaseiDDB_G0285071. echs1.

Phylogenomic databases

eggNOGiKOG1680. Eukaryota.
COG1024. LUCA.
InParanoidiQ1ZXF1.
KOiK07511.
OMAiVSKIYPV.
PhylomeDBiQ1ZXF1.

Enzyme and pathway databases

UniPathwayiUPA00659.
ReactomeiR-DDI-77310. Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA.
R-DDI-77346. Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA.
R-DDI-77348. Beta oxidation of octanoyl-CoA to hexanoyl-CoA.
R-DDI-77350. Beta oxidation of hexanoyl-CoA to butanoyl-CoA.
R-DDI-77352. Beta oxidation of butanoyl-CoA to acetyl-CoA.

Miscellaneous databases

PROiQ1ZXF1.

Family and domain databases

Gene3Di3.90.226.10. 1 hit.
InterProiIPR029045. ClpP/crotonase-like_dom.
IPR001753. Crotonase_core_superfam.
IPR018376. Enoyl-CoA_hyd/isom_CS.
[Graphical view]
PfamiPF00378. ECH_1. 1 hit.
[Graphical view]
SUPFAMiSSF52096. SSF52096. 1 hit.
PROSITEiPS00166. ENOYL_COA_HYDRATASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiECHM_DICDI
AccessioniPrimary (citable) accession number: Q1ZXF1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 2, 2006
Last modified: September 7, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.