Q1ZXC6 (ELP3_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable elongator complex protein 3
EC=2.3.1.48

Gene names

Name:	elp3
ORF Names:	DDB_G0290103

Organism

Dictyostelium discoideum (Slime mold) [Reference proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	559 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling. May also have a methyltransferase activity By similarity.
Catalytic activity	Acetyl-CoA + [histone] = CoA + acetyl-[histone].
Cofactor	Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine By similarity.
Subunit structure	Component of the RNA polymerase II elongator complex (Elongator). Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the ELP3 family. Contains 1 N-acetyltransferase domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Ligand	Iron Iron-sulfur Metal-binding S-adenosyl-L-methionine
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	regulation of transcription from RNA polymerase II promoter Inferred from sequence or structural similarity. Source: dictyBase transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	DNA-directed RNA polymerase II, holoenzyme Inferred from sequence or structural similarity. Source: dictyBase transcription elongation factor complex Inferred from sequence or structural similarity. Source: dictyBase
Molecular_function	histone acetyltransferase activity Inferred from sequence or structural similarity. Source: dictyBase iron-sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 559	559	Probable elongator complex protein 3		PRO_0000327510
Regions
	Domain	408 – 559	152	N-acetyltransferase
Sites
	Metal binding	111	1	Iron-sulfur (4Fe-4S-S-AdoMet) By similarity
	Metal binding	121	1	Iron-sulfur (4Fe-4S-S-AdoMet) By similarity
	Metal binding	124	1	Iron-sulfur (4Fe-4S-S-AdoMet) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1ZXC6 [UniParc]. Last modified May 2, 2006. Version 1. Checksum: B69CD84788F24AE2	FASTA	559	63,210
	10 20 30 40 50 60 MSLMNDPRPV SKKAGAKPVY GKNTPQFTKT VGEIVNALIN AYKEGKKVNL LKIKTELAAK 70 80 90 100 110 120 NSLSDQPKSV DIISAIPESY KNTLLPLLKA KPVRTASGIA VVAVMCKPHR CPHLAMTGNI 130 140 150 160 170 180 CVYCPGGPDS DFEYSTQSYT GYEPTSMRAI RARYNPFLQT RHRIDQLKRL GHNVEKVEFI 190 200 210 220 230 240 IMGGTFMSLP SDYRDYFIRN LHDALSGHTS NNVAEAVKYS EQSNVKCVGI TIETRPDHCL 250 260 270 280 290 300 KLHLSNMLTY GCTRLEIGVQ SVFEDIARDT NRGHTVRAVL ESFQLAKDSG FKVVAHMMPD 310 320 330 340 350 360 LPNMGMERDI YGFMEFFENP AFRADGLKIY PTLVIRGTGL YELWKTGTYK NYSPDSLVDL 370 380 390 400 410 420 IAKVLALVPP WTRIYRIQRD IPMPLVTSGV EYGNLRELCL ARMKDFGTKC RDVRTREVGI 430 440 450 460 470 480 QEVHHKIKPD QVELIRRDYV ANGGWETFLS FEDPKQDILI GLLRLRKCSE TSFRPELKEN 490 500 510 520 530 540 CSIVRELHVY GSVVGIHNRD PTKFQHQGYG TLLMEEAERI AREEHGSIKL AVIAGVGTRH 550 YYRKLGYELD GVYVSKYLG

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000153 Genomic DNA. Translation: EAS66831.1.
RefSeq	XP_001134514.1. XM_001134514.1.
3D structure databases
ProteinModelPortal	Q1ZXC6.
ModBase	Search...
Protein-protein interaction databases
STRING	44689.DDB_0231756.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0231756; DDB0231756; DDB_G0290103.
GeneID	8627480.
KEGG	ddi:DDB_G0290103.
Organism-specific databases
dictyBase	DDB_G0290103. elp3.
Phylogenomic databases
eggNOG	COG1243.
KO	K07739.
OMA	GIQEVHH.
ProtClustDB	CLSZ2429079.
Family and domain databases
Gene3D	3.40.630.30. 1 hit. 3.80.30.20. 1 hit.
InterPro	IPR016181. Acyl_CoA_acyltransferase. IPR006638. Elp3/MiaB/NifB. IPR000182. GNAT_dom. IPR005910. Hist_AcTrfase_ELP3. IPR007197. rSAM. IPR023404. rSAM_horseshoe. [Graphical view]
Pfam	PF00583. Acetyltransf_1. 1 hit. PF04055. Radical_SAM. 1 hit. [Graphical view]
PIRSF	PIRSF005669. Hist_AcTrfase_ELP3. 1 hit.
SMART	SM00729. Elp3. 1 hit. [Graphical view]
SUPFAM	SSF55729. Acyl_CoA_acyltransferase. 1 hit.
TIGRFAMs	TIGR01211. ELP3. 1 hit.
PROSITE	PS51186. GNAT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ELP3_DICDI

Accession

Primary (citable) accession number: Q1ZXC6

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	May 2, 2006
Last modified:	May 1, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)