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Q1ZXC6

- ELP3_DICDI

UniProt

Q1ZXC6 - ELP3_DICDI

Protein

Probable elongator complex protein 3

Gene

elp3

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 1 (02 May 2006)
      Previous versions | rss
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    Functioni

    Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling. May also have a methyltransferase activity By similarity.By similarity

    Catalytic activityi

    Acetyl-CoA + [histone] = CoA + acetyl-[histone].

    Cofactori

    Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi111 – 1111Iron-sulfur (4Fe-4S-S-AdoMet)By similarity
    Metal bindingi121 – 1211Iron-sulfur (4Fe-4S-S-AdoMet)By similarity
    Metal bindingi124 – 1241Iron-sulfur (4Fe-4S-S-AdoMet)By similarity

    GO - Molecular functioni

    1. histone acetyltransferase activity Source: dictyBase
    2. iron-sulfur cluster binding Source: UniProtKB-KW
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. histone acetylation Source: GOC
    2. regulation of transcription from RNA polymerase II promoter Source: dictyBase
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable elongator complex protein 3 (EC:2.3.1.48)
    Gene namesi
    Name:elp3
    ORF Names:DDB_G0290103
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 5, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0290103. elp3.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. DNA-directed RNA polymerase II, holoenzyme Source: dictyBase
    2. transcription elongation factor complex Source: dictyBase

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 559559Probable elongator complex protein 3PRO_0000327510Add
    BLAST

    Interactioni

    Subunit structurei

    Component of the RNA polymerase II elongator complex (Elongator). Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit By similarity.By similarity

    Protein-protein interaction databases

    STRINGi44689.DDB_0231756.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1ZXC6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini408 – 559152N-acetyltransferasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the ELP3 family.Curated
    Contains 1 N-acetyltransferase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG1243.
    KOiK07739.
    OMAiGYKVVSH.
    PhylomeDBiQ1ZXC6.

    Family and domain databases

    Gene3Di3.40.630.30. 1 hit.
    3.80.30.20. 1 hit.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR006638. Elp3/MiaB/NifB.
    IPR000182. GNAT_dom.
    IPR005910. Hist_AcTrfase_ELP3.
    IPR007197. rSAM.
    IPR023404. rSAM_horseshoe.
    [Graphical view]
    PfamiPF00583. Acetyltransf_1. 1 hit.
    PF04055. Radical_SAM. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005669. Hist_AcTrfase_ELP3. 1 hit.
    SMARTiSM00729. Elp3. 1 hit.
    [Graphical view]
    SUPFAMiSSF55729. SSF55729. 1 hit.
    TIGRFAMsiTIGR01211. ELP3. 1 hit.
    PROSITEiPS51186. GNAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1ZXC6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLMNDPRPV SKKAGAKPVY GKNTPQFTKT VGEIVNALIN AYKEGKKVNL    50
    LKIKTELAAK NSLSDQPKSV DIISAIPESY KNTLLPLLKA KPVRTASGIA 100
    VVAVMCKPHR CPHLAMTGNI CVYCPGGPDS DFEYSTQSYT GYEPTSMRAI 150
    RARYNPFLQT RHRIDQLKRL GHNVEKVEFI IMGGTFMSLP SDYRDYFIRN 200
    LHDALSGHTS NNVAEAVKYS EQSNVKCVGI TIETRPDHCL KLHLSNMLTY 250
    GCTRLEIGVQ SVFEDIARDT NRGHTVRAVL ESFQLAKDSG FKVVAHMMPD 300
    LPNMGMERDI YGFMEFFENP AFRADGLKIY PTLVIRGTGL YELWKTGTYK 350
    NYSPDSLVDL IAKVLALVPP WTRIYRIQRD IPMPLVTSGV EYGNLRELCL 400
    ARMKDFGTKC RDVRTREVGI QEVHHKIKPD QVELIRRDYV ANGGWETFLS 450
    FEDPKQDILI GLLRLRKCSE TSFRPELKEN CSIVRELHVY GSVVGIHNRD 500
    PTKFQHQGYG TLLMEEAERI AREEHGSIKL AVIAGVGTRH YYRKLGYELD 550
    GVYVSKYLG 559
    Length:559
    Mass (Da):63,210
    Last modified:May 2, 2006 - v1
    Checksum:iB69CD84788F24AE2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000153 Genomic DNA. Translation: EAS66831.1.
    RefSeqiXP_001134514.1. XM_001134514.1.

    Genome annotation databases

    EnsemblProtistsiDDB0231756; DDB0231756; DDB_G0290103.
    GeneIDi8627480.
    KEGGiddi:DDB_G0290103.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000153 Genomic DNA. Translation: EAS66831.1 .
    RefSeqi XP_001134514.1. XM_001134514.1.

    3D structure databases

    ProteinModelPortali Q1ZXC6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDB_0231756.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0231756 ; DDB0231756 ; DDB_G0290103 .
    GeneIDi 8627480.
    KEGGi ddi:DDB_G0290103.

    Organism-specific databases

    dictyBasei DDB_G0290103. elp3.

    Phylogenomic databases

    eggNOGi COG1243.
    KOi K07739.
    OMAi GYKVVSH.
    PhylomeDBi Q1ZXC6.

    Miscellaneous databases

    PROi Q1ZXC6.

    Family and domain databases

    Gene3Di 3.40.630.30. 1 hit.
    3.80.30.20. 1 hit.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR006638. Elp3/MiaB/NifB.
    IPR000182. GNAT_dom.
    IPR005910. Hist_AcTrfase_ELP3.
    IPR007197. rSAM.
    IPR023404. rSAM_horseshoe.
    [Graphical view ]
    Pfami PF00583. Acetyltransf_1. 1 hit.
    PF04055. Radical_SAM. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005669. Hist_AcTrfase_ELP3. 1 hit.
    SMARTi SM00729. Elp3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55729. SSF55729. 1 hit.
    TIGRFAMsi TIGR01211. ELP3. 1 hit.
    PROSITEi PS51186. GNAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiELP3_DICDI
    AccessioniPrimary (citable) accession number: Q1ZXC6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: May 2, 2006
    Last modified: October 1, 2014
    This is version 65 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3