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Q1ZXC6

- ELP3_DICDI

UniProt

Q1ZXC6 - ELP3_DICDI

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Protein
Probable elongator complex protein 3
Gene
elp3, DDB_G0290103
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling. May also have a methyltransferase activity By similarity.

Catalytic activityi

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Cofactori

Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi111 – 1111Iron-sulfur (4Fe-4S-S-AdoMet) By similarity
Metal bindingi121 – 1211Iron-sulfur (4Fe-4S-S-AdoMet) By similarity
Metal bindingi124 – 1241Iron-sulfur (4Fe-4S-S-AdoMet) By similarity

GO - Molecular functioni

  1. histone acetyltransferase activity Source: dictyBase
  2. iron-sulfur cluster binding Source: UniProtKB-KW
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. histone acetylation Source: GOC
  2. regulation of transcription from RNA polymerase II promoter Source: dictyBase
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Probable elongator complex protein 3 (EC:2.3.1.48)
Gene namesi
Name:elp3
ORF Names:DDB_G0290103
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 5, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0290103. elp3.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. DNA-directed RNA polymerase II, holoenzyme Source: dictyBase
  2. transcription elongation factor complex Source: dictyBase
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 559559Probable elongator complex protein 3
PRO_0000327510Add
BLAST

Interactioni

Subunit structurei

Component of the RNA polymerase II elongator complex (Elongator). Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit By similarity.

Protein-protein interaction databases

STRINGi44689.DDB_0231756.

Structurei

3D structure databases

ProteinModelPortaliQ1ZXC6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini408 – 559152N-acetyltransferase
Add
BLAST

Sequence similaritiesi

Belongs to the ELP3 family.

Phylogenomic databases

eggNOGiCOG1243.
KOiK07739.
OMAiGYKVVSH.
PhylomeDBiQ1ZXC6.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
3.80.30.20. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR006638. Elp3/MiaB/NifB.
IPR000182. GNAT_dom.
IPR005910. Hist_AcTrfase_ELP3.
IPR007197. rSAM.
IPR023404. rSAM_horseshoe.
[Graphical view]
PfamiPF00583. Acetyltransf_1. 1 hit.
PF04055. Radical_SAM. 1 hit.
[Graphical view]
PIRSFiPIRSF005669. Hist_AcTrfase_ELP3. 1 hit.
SMARTiSM00729. Elp3. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
TIGRFAMsiTIGR01211. ELP3. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1ZXC6-1 [UniParc]FASTAAdd to Basket

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MSLMNDPRPV SKKAGAKPVY GKNTPQFTKT VGEIVNALIN AYKEGKKVNL    50
LKIKTELAAK NSLSDQPKSV DIISAIPESY KNTLLPLLKA KPVRTASGIA 100
VVAVMCKPHR CPHLAMTGNI CVYCPGGPDS DFEYSTQSYT GYEPTSMRAI 150
RARYNPFLQT RHRIDQLKRL GHNVEKVEFI IMGGTFMSLP SDYRDYFIRN 200
LHDALSGHTS NNVAEAVKYS EQSNVKCVGI TIETRPDHCL KLHLSNMLTY 250
GCTRLEIGVQ SVFEDIARDT NRGHTVRAVL ESFQLAKDSG FKVVAHMMPD 300
LPNMGMERDI YGFMEFFENP AFRADGLKIY PTLVIRGTGL YELWKTGTYK 350
NYSPDSLVDL IAKVLALVPP WTRIYRIQRD IPMPLVTSGV EYGNLRELCL 400
ARMKDFGTKC RDVRTREVGI QEVHHKIKPD QVELIRRDYV ANGGWETFLS 450
FEDPKQDILI GLLRLRKCSE TSFRPELKEN CSIVRELHVY GSVVGIHNRD 500
PTKFQHQGYG TLLMEEAERI AREEHGSIKL AVIAGVGTRH YYRKLGYELD 550
GVYVSKYLG 559
Length:559
Mass (Da):63,210
Last modified:May 2, 2006 - v1
Checksum:iB69CD84788F24AE2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000153 Genomic DNA. Translation: EAS66831.1.
RefSeqiXP_001134514.1. XM_001134514.1.

Genome annotation databases

EnsemblProtistsiDDB0231756; DDB0231756; DDB_G0290103.
GeneIDi8627480.
KEGGiddi:DDB_G0290103.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000153 Genomic DNA. Translation: EAS66831.1 .
RefSeqi XP_001134514.1. XM_001134514.1.

3D structure databases

ProteinModelPortali Q1ZXC6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0231756.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0231756 ; DDB0231756 ; DDB_G0290103 .
GeneIDi 8627480.
KEGGi ddi:DDB_G0290103.

Organism-specific databases

dictyBasei DDB_G0290103. elp3.

Phylogenomic databases

eggNOGi COG1243.
KOi K07739.
OMAi GYKVVSH.
PhylomeDBi Q1ZXC6.

Miscellaneous databases

PROi Q1ZXC6.

Family and domain databases

Gene3Di 3.40.630.30. 1 hit.
3.80.30.20. 1 hit.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR006638. Elp3/MiaB/NifB.
IPR000182. GNAT_dom.
IPR005910. Hist_AcTrfase_ELP3.
IPR007197. rSAM.
IPR023404. rSAM_horseshoe.
[Graphical view ]
Pfami PF00583. Acetyltransf_1. 1 hit.
PF04055. Radical_SAM. 1 hit.
[Graphical view ]
PIRSFi PIRSF005669. Hist_AcTrfase_ELP3. 1 hit.
SMARTi SM00729. Elp3. 1 hit.
[Graphical view ]
SUPFAMi SSF55729. SSF55729. 1 hit.
TIGRFAMsi TIGR01211. ELP3. 1 hit.
PROSITEi PS51186. GNAT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiELP3_DICDI
AccessioniPrimary (citable) accession number: Q1ZXC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 2, 2006
Last modified: September 3, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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