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Q1ZXC6 (ELP3_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable elongator complex protein 3

EC=2.3.1.48
Gene names
Name:elp3
ORF Names:DDB_G0290103
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length559 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalytic histone acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling. May also have a methyltransferase activity By similarity.

Catalytic activity

Acetyl-CoA + [histone] = CoA + acetyl-[histone].

Cofactor

Binds 1 4Fe-4S cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine By similarity.

Subunit structure

Component of the RNA polymerase II elongator complex (Elongator). Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the ELP3 family.

Contains 1 N-acetyltransferase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 559559Probable elongator complex protein 3
PRO_0000327510

Regions

Domain408 – 559152N-acetyltransferase

Sites

Metal binding1111Iron-sulfur (4Fe-4S-S-AdoMet) By similarity
Metal binding1211Iron-sulfur (4Fe-4S-S-AdoMet) By similarity
Metal binding1241Iron-sulfur (4Fe-4S-S-AdoMet) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1ZXC6 [UniParc].

Last modified May 2, 2006. Version 1.
Checksum: B69CD84788F24AE2

FASTA55963,210
        10         20         30         40         50         60 
MSLMNDPRPV SKKAGAKPVY GKNTPQFTKT VGEIVNALIN AYKEGKKVNL LKIKTELAAK 

        70         80         90        100        110        120 
NSLSDQPKSV DIISAIPESY KNTLLPLLKA KPVRTASGIA VVAVMCKPHR CPHLAMTGNI 

       130        140        150        160        170        180 
CVYCPGGPDS DFEYSTQSYT GYEPTSMRAI RARYNPFLQT RHRIDQLKRL GHNVEKVEFI 

       190        200        210        220        230        240 
IMGGTFMSLP SDYRDYFIRN LHDALSGHTS NNVAEAVKYS EQSNVKCVGI TIETRPDHCL 

       250        260        270        280        290        300 
KLHLSNMLTY GCTRLEIGVQ SVFEDIARDT NRGHTVRAVL ESFQLAKDSG FKVVAHMMPD 

       310        320        330        340        350        360 
LPNMGMERDI YGFMEFFENP AFRADGLKIY PTLVIRGTGL YELWKTGTYK NYSPDSLVDL 

       370        380        390        400        410        420 
IAKVLALVPP WTRIYRIQRD IPMPLVTSGV EYGNLRELCL ARMKDFGTKC RDVRTREVGI 

       430        440        450        460        470        480 
QEVHHKIKPD QVELIRRDYV ANGGWETFLS FEDPKQDILI GLLRLRKCSE TSFRPELKEN 

       490        500        510        520        530        540 
CSIVRELHVY GSVVGIHNRD PTKFQHQGYG TLLMEEAERI AREEHGSIKL AVIAGVGTRH 

       550 
YYRKLGYELD GVYVSKYLG 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000153 Genomic DNA. Translation: EAS66831.1.

3D structure databases

ProteinModelPortalQ1ZXC6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDB_0231756.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0231756; DDB0231756; DDB_G0290103.
KEGGddi:DDB_G0290103.

Organism-specific databases

dictyBaseDDB_G0290103. elp3.

Phylogenomic databases

eggNOGCOG1243.
KOK07739.
OMAGYKVVSH.
PhylomeDBQ1ZXC6.
ProtClustDBCLSZ2429079.

Family and domain databases

Gene3D3.40.630.30. 1 hit.
3.80.30.20. 1 hit.
InterProIPR016181. Acyl_CoA_acyltransferase.
IPR006638. Elp3/MiaB/NifB.
IPR000182. GNAT_dom.
IPR005910. Hist_AcTrfase_ELP3.
IPR007197. rSAM.
IPR023404. rSAM_horseshoe.
[Graphical view]
PfamPF00583. Acetyltransf_1. 1 hit.
PF04055. Radical_SAM. 1 hit.
[Graphical view]
PIRSFPIRSF005669. Hist_AcTrfase_ELP3. 1 hit.
SMARTSM00729. Elp3. 1 hit.
[Graphical view]
SUPFAMSSF55729. SSF55729. 1 hit.
TIGRFAMsTIGR01211. ELP3. 1 hit.
PROSITEPS51186. GNAT. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ1ZXC6.

Entry information

Entry nameELP3_DICDI
AccessionPrimary (citable) accession number: Q1ZXC6
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 2, 2006
Last modified: April 16, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase