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Protein

Interphotoreceptor matrix proteoglycan 2

Gene

IMPG2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Chondroitin sulfate- and hyaluronan-binding proteoglycan involved in the organization of interphotoreceptor matrix.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHeparin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Interphotoreceptor matrix proteoglycan 2
Alternative name(s):
Sialoprotein associated with cones and rods proteoglycan
Short name:
Spacrcan
Gene namesi
Name:IMPG2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini28 – 1289ExtracellularSequence analysisAdd BLAST1262
Transmembranei1290 – 1310HelicalSequence analysisAdd BLAST21
Topological domaini1311 – 1423CytoplasmicSequence analysisAdd BLAST113

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000032015228 – 1423Interphotoreceptor matrix proteoglycan 2Add BLAST1396

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi150N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi325N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi375N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi676N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1128N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1142N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1160N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1200 ↔ 1211PROSITE-ProRule annotation
Disulfide bondi1205 ↔ 1222PROSITE-ProRule annotation
Disulfide bondi1240 ↔ 1253PROSITE-ProRule annotation
Disulfide bondi1247 ↔ 1263PROSITE-ProRule annotation
Disulfide bondi1265 ↔ 1278PROSITE-ProRule annotation

Post-translational modificationi

Highly glycosylated (N- and O-linked carbohydrates).1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ1XI86.

Expressioni

Tissue specificityi

Expressed in retina.1 Publication

Developmental stagei

Detected in retina at E12 with increased expression up to a peak at E16.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000036121.

Structurei

3D structure databases

ProteinModelPortaliQ1XI86.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini245 – 358SEA 1PROSITE-ProRule annotationAdd BLAST114
Domaini1083 – 1196SEA 2PROSITE-ProRule annotationAdd BLAST114
Domaini1196 – 1234EGF-like 1PROSITE-ProRule annotationAdd BLAST39
Domaini1237 – 1279EGF-like 2PROSITE-ProRule annotationAdd BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni265 – 273Hyaluronan-binding motif involved in chondroitin sulfate A-bindingBy similarity9
Regioni1266 – 1274Hyaluronan-binding motif involved in chondroitin sulfate C-bindingBy similarity9
Regioni1322 – 1327Hyaluronan-binding motif involved in chondroitin sulfate C-bindingBy similarity6

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IH0G. Eukaryota.
ENOG410Y9FF. LUCA.
HOGENOMiHOG000113064.
HOVERGENiHBG108006.
InParanoidiQ1XI86.
KOiK19017.
PhylomeDBiQ1XI86.

Family and domain databases

Gene3Di3.30.70.960. 2 hits.
InterProiView protein in InterPro
IPR000742. EGF-like_dom.
IPR032975. IMPG2.
IPR000082. SEA_dom.
PANTHERiPTHR12199:SF13. PTHR12199:SF13. 1 hit.
PfamiView protein in Pfam
PF01390. SEA. 2 hits.
SMARTiView protein in SMART
SM00200. SEA. 2 hits.
SUPFAMiSSF82671. SSF82671. 2 hits.
PROSITEiView protein in PROSITE
PS01186. EGF_2. 1 hit.
PS50026. EGF_3. 2 hits.
PS50024. SEA. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q1XI86-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFAFLWKISL CLLVLGVITG DPQAVAAEEK QAKDASPTPQ LGVWQFASPS
60 70 80 90 100
LPPELRKLHG IVEAEQVNRH LLRRRKRSIL FPSGVKICPD ESVEQAIANH
110 120 130 140 150
LKYFRLRVCQ ETVWEVFKTF WDRLPEREEY HTWMSLCEEG TMSIFEMGMN
160 170 180 190 200
FSQSEEHRSL IVKKLSYTKE AMAGSCTDWS CGGTPTPASD ADATTLRDAA
210 220 230 240 250
ANVPPPHEVS IESPPGGTSH EIEDADTTIN NEIKKEDEIP VRPVTEQMIE
260 270 280 290 300
FSIVIAGEKY SEELSDPDTA KYQLLSEQFV SQIQNVFEGL PGYKNIHVLE
310 320 330 340 350
FSSPEEDSGV EVHYAVTFDG EAISNATWDL INLHSNKVED NSFMGIEDNP
360 370 380 390 400
TVVYTISDFQ DYIAEILQKN ALLENTSLTL DPNSLQLINV KEILHPTQED
410 420 430 440 450
PSWITEHPTV LEHVEFDDNT FSAERPSADE STVSNTLPFD FTKPDSTLDS
460 470 480 490 500
EESDDNEIRP RPESLDSEVS LIPEAPLSSE ADVTSLPDGL XLADWNQTPA
510 520 530 540 550
LVTAPVIEHD SLDSLEWLSA PDSSDEFEDT GLSDDFLLPS SPSSHLVPEE
560 570 580 590 600
PPSTDDYTAP LLSAPTVASS SVIETDTKRT VTAEKEVVTQ GSPADSSSAD
610 620 630 640 650
SLLHEXVEES PFPLEVHPVE GEXDIYLGDR MIFDDGSGSA FDGSGKGMEP
660 670 680 690 700
SIWPWDVATL EPVFYPGPDS WLDDDNDSLP FRTEDIPEGL ILDYILNSGN
710 720 730 740 750
KLDDDPSKDE NEGVASIKEN FLDESEIFVF PETTTQQVPL LQTGEPSSVE
760 770 780 790 800
TSTQMETLSM DDDSFVKPSF VLEPPEDYSF ADLPTGEDLF LPHSTGVSVE
810 820 830 840 850
DTLLTSTVTL GXEDSLLTST VAFSVEQPEE SSVGQEIISE AXEHQNEDRP
860 870 880 890 900
TVEELFTAGQ SNVGEAATVG YLDKSSLETV LTAEPFEVST DTSTEEQQSL
910 920 930 940 950
DSSLADRDTG LAIRKPADVW PTDRVLEKTL DQTVQSAVPT AAQVSTAVPS
960 970 980 990 1000
LIHQATALEG FAGQDGTEHD THVSMSISTI LNSYVTITAD TVELPSHLPP
1010 1020 1030 1040 1050
MTTTVSSSVV TLAKVGDETT RVLDVSVDLD HVSMVSFSPE PSEEAKSMTD
1060 1070 1080 1090 1100
SHMELTTHAH STEMAGVAWP THEIHNSTPV PSRALVVFFS LRVTNMMFSE
1110 1120 1130 1140 1150
DLFNKNSPEY KALEQRFLEL LVPYLQSNLT GFQNLEILNF RNGSIVVNSR
1160 1170 1180 1190 1200
MKFAKPVPRN VTNAVYMILE DFCNTAYHTM NLAIDKYSLD VESGEQADPC
1210 1220 1230 1240 1250
KFQACNEFSE CLVNRWSGEA ECVCNPGYLS IDGLPCNSIC DLQPNFCLND
1260 1270 1280 1290 1300
GKCDISPGQG AICRCRVGEN WWYRGEHCEE YVSEPLVVGI AIASVAGFLL
1310 1320 1330 1340 1350
VASAVIFFLA RTLRDQYTKS DTEDSQGQGD SLSSIENAVK YNPMYESDTT
1360 1370 1380 1390 1400
GYSHYYRRYP QLTSYSSTSA ETSTDYSSEE IRHIYENSEL TKEEIQDRIR
1410 1420
IIELYAKDRQ FAEFVRQHQM KLL
Length:1,423
Mass (Da):157,540
Last modified:May 2, 2006 - v1
Checksum:i770AB61AEC4E17FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB204591 mRNA. Translation: BAE92938.1.
RefSeqiNP_001038104.2. NM_001044639.2.
UniGeneiGga.33749.

Genome annotation databases

GeneIDi418393.
KEGGigga:418393.

Similar proteinsi

Entry informationi

Entry nameiIMPG2_CHICK
AccessioniPrimary (citable) accession number: Q1XI86
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: May 2, 2006
Last modified: May 10, 2017
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome