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Q1XHL7

- GRK7B_DANRE

UniProt

Q1XHL7 - GRK7B_DANRE

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Protein

G protein-coupled receptor kinase 7B

Gene

grk7b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Retina-specific kinase involved in the shutoff of the photoresponse and adaptation to changing light conditions via cone opsin phosphorylation, including rhodopsin (RHO).1 Publication

Catalytic activityi

ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate.
ATP + [rhodopsin] = ADP + [rhodopsin] phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei216 – 2161ATPPROSITE-ProRule annotation
Active sitei312 – 3121Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi193 – 2019ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. G-protein coupled receptor kinase activity Source: UniProtKB-EC
  3. rhodopsin kinase activity Source: UniProtKB

GO - Biological processi

  1. signal transduction Source: InterPro
  2. termination of G-protein coupled receptor signaling pathway Source: InterPro
  3. visual perception Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Biological processi

Sensory transduction, Vision

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAi2.7.11.14. 96826.

Names & Taxonomyi

Protein namesi
Recommended name:
G protein-coupled receptor kinase 7B (EC:2.7.11.14, EC:2.7.11.16)
Alternative name(s):
G protein-coupled receptor kinase 7-2
Gene namesi
Name:grk7b
Synonyms:grk7-2
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Chromosome 18

Organism-specific databases

ZFINiZDB-GENE-030904-3. grk7b.

Subcellular locationi

Membrane By similarity; Lipid-anchor By similarity

GO - Cellular componenti

  1. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 545545G protein-coupled receptor kinase 7BPRO_0000412814Add
BLAST
Propeptidei546 – 5483Removed in mature formBy similarityPRO_0000412815

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei33 – 331Phosphoserine; by PKA
Modified residuei545 – 5451Cysteine methyl esterSequence Analysis
Lipidationi545 – 5451S-geranylgeranyl cysteineSequence Analysis

Post-translational modificationi

Phosphorylation at Ser-33 is regulated by light and activated by cAMP.By similarity

Keywords - PTMi

Lipoprotein, Methylation, Phosphoprotein, Prenylation

Expressioni

Tissue specificityi

Expressed in the eyes (at protein level). Expressed in the eyes, the pineal gland and in the brain.1 Publication

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini53 – 172120RGSPROSITE-ProRule annotationAdd
BLAST
Domaini187 – 446260Protein kinasePROSITE-ProRule annotationAdd
BLAST
Domaini447 – 51266AGC-kinase C-terminalAdd
BLAST

Sequence similaritiesi

Contains 1 AGC-kinase C-terminal domain.Curated
Contains 1 protein kinase domain.PROSITE-ProRule annotation
Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00760000118793.
HOVERGENiHBG004532.
InParanoidiQ1XHL7.
OMAiGIEMERI.
OrthoDBiEOG7V1FQK.
TreeFamiTF313940.

Family and domain databases

InterProiIPR000961. AGC-kinase_C.
IPR000239. GPCR_kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR00717. GPCRKINASE.
SMARTiSM00315. RGS. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEiPS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q1XHL7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSDMGGLKNL VANTDYLKAQ SLDEKEIKKR RCSLGLPHLG NCTDVRVSVS
60 70 80 90 100
KGFEDICEQQ PIGRACFRQF LSVSSPEYLA AAELLDELNC WNLAEAEAKE
110 120 130 140 150
EARLNIINKF CKADSKSFLA FLTEDEAEKC KAVSEKDFEE VMMGQVKEAT
160 170 180 190 200
QKFLRGQPFE EYQTSLFFDR FVQWKKFEKQ PITDKYFYEF RTLGKGGFGE
210 220 230 240 250
VCGVQVKTTG QMYACKKLDK KRLKKKSGEK MALLEKKILE MVNSLFIVNL
260 270 280 290 300
AYAFDTKTHL CLVMTLMSGG DLKYHIFHVG EVGIEMERII HYTAQITSGI
310 320 330 340 350
LHLHSMDIVY RDMKPENVLL DCQGQCRLSD LGLAVELPNG KTTTQKAGTK
360 370 380 390 400
GYMAPEILKQ EPYRTSVDWW ALGCSIYEMV AGRVPFRDHK EKVAKEELLR
410 420 430 440 450
RTLEDEVKFE HRNFDAPSKD IISLFLKRNI EDRLGSNDDP RKHEFFKSIN
460 470 480 490 500
FPRLEAGLIP PPWEPKANVV YAKDTGDIRE FSDVKGVKFD ANDEKFFKEF
510 520 530 540
STGVVPIAWQ QEMIDSGLFD ELSDPNRKES AAGLEDEEQQ KSKSCTLL
Length:548
Mass (Da):62,609
Last modified:September 21, 2011 - v2
Checksum:i939D0B13095FECF2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti47 – 471V → A in BAE92859. (PubMed:16787417)Curated
Sequence conflicti47 – 471V → A in AAI62212. 1 PublicationCurated
Sequence conflicti339 – 3391N → D in BAE92859. (PubMed:16787417)Curated
Sequence conflicti339 – 3391N → D in AAI62212. 1 PublicationCurated
Sequence conflicti339 – 3391N → D in AAI62221. 1 PublicationCurated
Sequence conflicti412 – 4121R → Q in BAE92859. (PubMed:16787417)Curated
Sequence conflicti412 – 4121R → Q in AAI62212. 1 PublicationCurated
Sequence conflicti412 – 4121R → Q in AAI62221. 1 PublicationCurated
Sequence conflicti504 – 5041V → A in BAE92859. (PubMed:16787417)Curated
Sequence conflicti504 – 5041V → A in AAI62212. 1 PublicationCurated
Sequence conflicti504 – 5041V → A in AAI62221. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB212996 mRNA. Translation: BAE92859.1.
BC162212 mRNA. Translation: AAI62212.1.
BC162221 mRNA. Translation: AAI62221.1.
UniGeneiDr.88577.

Genome annotation databases

EnsembliENSDART00000077898; ENSDARP00000072364; ENSDARG00000055534.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB212996 mRNA. Translation: BAE92859.1 .
BC162212 mRNA. Translation: AAI62212.1 .
BC162221 mRNA. Translation: AAI62221.1 .
UniGenei Dr.88577.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSDART00000077898 ; ENSDARP00000072364 ; ENSDARG00000055534 .

Organism-specific databases

ZFINi ZDB-GENE-030904-3. grk7b.

Phylogenomic databases

GeneTreei ENSGT00760000118793.
HOVERGENi HBG004532.
InParanoidi Q1XHL7.
OMAi GIEMERI.
OrthoDBi EOG7V1FQK.
TreeFami TF313940.

Enzyme and pathway databases

BRENDAi 2.7.11.14. 96826.

Family and domain databases

InterProi IPR000961. AGC-kinase_C.
IPR000239. GPCR_kinase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR016137. Regulat_G_prot_signal_superfam.
IPR000342. RGS_dom.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view ]
PRINTSi PR00717. GPCRKINASE.
SMARTi SM00315. RGS. 1 hit.
SM00133. S_TK_X. 1 hit.
SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF48097. SSF48097. 1 hit.
SSF56112. SSF56112. 1 hit.
PROSITEi PS51285. AGC_KINASE_CTER. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "GRK1 and GRK7: unique cellular distribution and widely different activities of opsin phosphorylation in the zebrafish rods and cones."
    Wada Y., Sugiyama J., Okano T., Fukada Y.
    J. Neurochem. 98:824-837(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], BIOPHYSICOCHEMICAL PROPERTIES, TISSUE SPECIFICITY, FUNCTION.
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiGRK7B_DANRE
AccessioniPrimary (citable) accession number: Q1XHL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 21, 2011
Last sequence update: September 21, 2011
Last modified: October 29, 2014
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Although the protein is present in a diversity of vertebrates ranging from bony fish to mammals, the mouse and rat orthologous proteins do not exist.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3