Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

SKI/DACH domain-containing protein 1

Gene

SKIDA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
SKI/DACH domain-containing protein 1
Alternative name(s):
Protein DLN-1
Gene namesi
Name:SKIDA1
Synonyms:C10orf140, DLN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

EuPathDBiHostDB:ENSG00000180592.16
HGNCiHGNC:32697 SKIDA1
neXtProtiNX_Q1XH10

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000180592
PharmGKBiPA162377645

Polymorphism and mutation databases

BioMutaiSKIDA1
DMDMi121940921

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003285291 – 908SKI/DACH domain-containing protein 1Add BLAST908

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki688Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ1XH10
PeptideAtlasiQ1XH10
PRIDEiQ1XH10

PTM databases

iPTMnetiQ1XH10
PhosphoSitePlusiQ1XH10

Expressioni

Gene expression databases

BgeeiENSG00000180592
CleanExiHS_C10orf140
ExpressionAtlasiF5H7M0 baseline and differential
GenevisibleiE9PAX1 HS

Organism-specific databases

HPAiHPA039208
HPA040439

Interactioni

Protein-protein interaction databases

BioGridi132378, 1 interactor
IntActiQ1XH10, 2 interactors

Structurei

3D structure databases

ProteinModelPortaliQ1XH10
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi122 – 125Poly-Ala4
Compositional biasi160 – 163Poly-Ala4
Compositional biasi224 – 320Ala-richPROSITE-ProRule annotationAdd BLAST97
Compositional biasi337 – 371His-richPROSITE-ProRule annotationAdd BLAST35
Compositional biasi374 – 463Ser-richPROSITE-ProRule annotationAdd BLAST90
Compositional biasi412 – 449Glu-richPROSITE-ProRule annotationAdd BLAST38
Compositional biasi488 – 493Poly-Ala6

Sequence similaritiesi

Belongs to the DACH/dachshund family.Curated

Phylogenomic databases

eggNOGiENOG410II10 Eukaryota
ENOG41116AE LUCA
GeneTreeiENSGT00530000064183
HOGENOMiHOG000112223
HOVERGENiHBG063887
InParanoidiQ1XH10
OMAiWKWQLGG
OrthoDBiEOG091G02LG
PhylomeDBiQ1XH10
TreeFamiTF332913

Family and domain databases

Gene3Di3.10.260.20, 1 hit
InterProiView protein in InterPro
IPR009061 DNA-bd_dom_put_sf
IPR027971 EPOP
IPR003380 SKI/SNO/DAC
IPR037000 Ski_DNA-bd_sf
PfamiView protein in Pfam
PF15223 DUF4584, 1 hit
PF02437 Ski_Sno, 1 hit
SUPFAMiSSF46955 SSF46955, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative initiation. AlignAdd to basket

Isoform 1 (identifier: Q1XH10-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGDLKSGFEE VDGVRLGYLI IKGKQMFALS QVFTDLLKNI PRTTVHKRMD
60 70 80 90 100
HLKVKKHHCD LEELRKLKAI NSIAFHAAKC TLISREDVEA LYTSCKTERV
110 120 130 140 150
LKTKRRRVGR ALATKAPPPE RAAAASPRPG FWKDKHQLWR GLSGAARPLP
160 170 180 190 200
ISAQSQRPGA AAARPAAHLP QIFSKYPGSH YPEIVRSPCK PPLNYETAPL
210 220 230 240 250
QGNYVAFPSD PAYFRSLLCS KHPAAAAAAA AAAAAAAAAA AAAAYYQVSA
260 270 280 290 300
AGPQPKAAAG AGGPGSLSYR CKRKRGGAKD CLLAPHAGAR RLLLLPRSYK
310 320 330 340 350
AKAAAAAAAA AAAAAAAAGA TCLERFHLVN GFCPPPHHHH HHHHHHHHHH
360 370 380 390 400
HRAQPPQQSH HPPHHHRPQP HLGSFPESCS SDSESSSYSD HAANDSDFGS
410 420 430 440 450
SLSSSSNSVS SEEEEEEGEE EEEEEEEEGG SGASDSSEVS SEEEDSSTES
460 470 480 490 500
DSSSGSSQVS VQSIRFRRTS FCKPPSVQAQ ANFLYHLASA AAATKPAAFE
510 520 530 540 550
DAGRLPDLKS SVKAESPAEW NLQSWAPKAS PVYCPASLGS CFAEIRNDRV
560 570 580 590 600
SEITFPHSEI SNAVKRTDLT INCLAEGASS PSPKTNNAFP QQRILREARK
610 620 630 640 650
CLQTTPTTHC ADNNTIAARF LNNDSSGAEA NSEKYSKILH CPEFATDLPS
660 670 680 690 700
SQTDPEVNAA GAAATKAENP CTDTGDKTLP FLHNIKIKVE DSSANEEYEP
710 720 730 740 750
HLFTNKLKCE CNDTKGEFYS VTESKEEDAL LTTAKEGFAC PEKETPSLNP
760 770 780 790 800
LAQSQGLSCT LGSPKPEDGE YKFGARVRKN YRTLVLGKRP VLQTPPVKPN
810 820 830 840 850
LKSARSPRPT GKTETNEGTL DDFTVINRRK KVASNVASAV KRPFHFMANF
860 870 880 890 900
PCPPSLIIGR DGDLWPAYSL NTTKDSQTPH KAHPIWKWQL GGSAIPLPPS

HKFRKFNS
Length:908
Mass (Da):98,148
Last modified:March 28, 2018 - v2
Checksum:i6B028EAA32881D2B
GO
Isoform 2 (identifier: Q1XH10-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     240-318: Missing.

Show »
Length:829
Mass (Da):90,618
Checksum:i6DBF51AF770603D4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti229 – 239Missing in BAD18601 (PubMed:14702039).CuratedAdd BLAST11
Sequence conflicti238 – 239Missing in BAE93016 (Ref. 1) Curated2
Sequence conflicti428E → EEE in BAD18601 (PubMed:14702039).Curated1
Sequence conflicti428E → EEE in CAD39106 (PubMed:17974005).Curated1
Sequence conflicti850F → K in BAD18601 (PubMed:14702039).Curated1

Polymorphismi

The poly-Ala region of SKIDA1 is highly polymorphic and the number of Ala can vary.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_059383240 – 318Missing in isoform 2. Add BLAST79

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB234866 mRNA Translation: BAE93016.1
AK131456 mRNA Translation: BAD18601.1
AL358780 Genomic DNA No translation available.
AL834446 mRNA Translation: CAD39106.1
RefSeqiNP_997254.3, NM_207371.3
XP_005252507.1, XM_005252450.3
XP_011517782.1, XM_011519480.2
XP_016871714.1, XM_017016225.1
XP_016871715.1, XM_017016226.1
UniGeneiHs.350848
Hs.694676

Genome annotation databases

EnsembliENST00000444772; ENSP00000442432; ENSG00000180592 [Q1XH10-2]
ENST00000449193; ENSP00000410041; ENSG00000180592 [Q1XH10-1]
GeneIDi387640
KEGGihsa:387640

Keywords - Coding sequence diversityi

Alternative initiation

Similar proteinsi

Entry informationi

Entry nameiSKDA1_HUMAN
AccessioniPrimary (citable) accession number: Q1XH10
Secondary accession number(s): B1ANA5
, E9PAX1, F5H7M0, Q6ZMX4, Q8N3C3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: March 28, 2018
Last modified: April 25, 2018
This is version 86 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health