Q1XH10 (DLN1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein DLN-1

Gene names

Name:	C10orf140
Synonyms:	DLN1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	827 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Polymorphism	The poly-Ala region of C10orf140 is highly polymorphic and the number of Ala can vary.
Sequence similarities	Belongs to the DACH/dachshund family.

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	nucleus Inferred from electronic annotation. Source: InterPro
Molecular function	nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 827	827	Protein DLN-1		PRO_0000328529
Regions
	Compositional bias	122 – 125	4	Poly-Ala
	Compositional bias	160 – 163	4	Poly-Ala
	Compositional bias	224 – 239	16	Ala-rich
	Compositional bias	256 – 290	35	His-rich
	Compositional bias	293 – 382	90	Ser-rich
	Compositional bias	331 – 368	38	Glu-rich
	Compositional bias	407 – 412	6	Poly-Ala
Experimental info
	Sequence conflict	229 – 237	9	Missing in BAD18601. Ref.2
	Sequence conflict	347	1	E → EEE in BAD18601. Ref.2
	Sequence conflict	347	1	E → EEE in CAD39106. Ref.4
	Sequence conflict	769	1	F → K in BAD18601. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q1XH10 [UniParc]. Last modified May 2, 2006. Version 1. Checksum: 72A4FA20C06C85EB	FASTA	827	90,476
	10 20 30 40 50 60 MGDLKSGFEE VDGVRLGYLI IKGKQMFALS QVFTDLLKNI PRTTVHKRMD HLKVKKHHCD 70 80 90 100 110 120 LEELRKLKAI NSIAFHAAKC TLISREDVEA LYTSCKTERV LKTKRRRVGR ALATKAPPPE 130 140 150 160 170 180 RAAAASPRPG FWKDKHQLWR GLSGAARPLP ISAQSQRPGA AAARPAAHLP QIFSKYPGSH 190 200 210 220 230 240 YPEIVRSPCK PPLNYETAPL QGNYVAFPSD PAYFRSLLCS KHPAAAAAAA AAAAAAAGAT 250 260 270 280 290 300 CLERFHLVNG FCPPPHHHHH HHHHHHHHHH RAQPPQQSHH PPHHHRPQPH LGSFPESCSS 310 320 330 340 350 360 DSESSSYSDH AANDSDFGSS LSSSSNSVSS EEEEEEGEEE EEEEEEEGGS GASDSSEVSS 370 380 390 400 410 420 EEEDSSTESD SSSGSSQVSV QSIRFRRTSF CKPPSVQAQA NFLYHLASAA AATKPAAFED 430 440 450 460 470 480 AGRLPDLKSS VKAESPAEWN LQSWAPKASP VYCPASLGSC FAEIRNDRVS EITFPHSEIS 490 500 510 520 530 540 NAVKRTDLTI NCLAEGASSP SPKTNNAFPQ QRILREARKC LQTTPTTHCA DNNTIAARFL 550 560 570 580 590 600 NNDSSGAEAN SEKYSKILHC PEFATDLPSS QTDPEVNAAG AAATKAENPC TDTGDKTLPF 610 620 630 640 650 660 LHNIKIKVED SSANEEYEPH LFTNKLKCEC NDTKGEFYSV TESKEEDALL TTAKEGFACP 670 680 690 700 710 720 EKETPSLNPL AQSQGLSCTL GSPKPEDGEY KFGARVRKNY RTLVLGKRPV LQTPPVKPNL 730 740 750 760 770 780 KSARSPRPTG KTETNEGTLD DFTVINRRKK VASNVASAVK RPFHFMANFP CPPSLIIGRD 790 800 810 820 GDLWPAYSLN TTKDSQTPHK AHPIWKWQLG GSAIPLPPSH KFRKFNS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of a full-length human DLN-1 gene." Takenobu H., Ohira M., Nakamura Y., Hirata T., Nakagawara A. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Neuroblastoma.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[3]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 265-827. Tissue: Amygdala.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB234866 mRNA. Translation: BAE93016.1. AK131456 mRNA. Translation: BAD18601.1. AL358780 Genomic DNA. Translation: CAI13978.2. AL834446 mRNA. Translation: CAD39106.1.
IPI	IPI00166533.
RefSeq	NP_997254.3. NM_207371.3.
UniGene	Hs.350848.
3D structure databases
ProteinModelPortal	Q1XH10.
SMR	Q1XH10. Positions 4-98.
ModBase	Search...
Polymorphism databases
DMDM	121940921.
Proteomic databases
PRIDE	Q1XH10.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000317413; ENSP00000326863; ENSG00000180592.
GeneID	387640.
KEGG	hsa:387640.
UCSC	uc009xkd.1. human.
Organism-specific databases
CTD	387640.
GeneCards	GC10M021843.
H-InvDB	HIX0022018.
HGNC	HGNC:32697. C10orf140.
HPA	HPA039208. HPA040439.
neXtProt	NX_Q1XH10.
PharmGKB	PA162377645.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00530000064183.
HOVERGEN	HBG063887.
InParanoid	Q1XH10.
OrthoDB	EOG4HQDJ6.
Gene expression databases
ArrayExpress	Q1XH10.
Bgee	Q1XH10.
CleanEx	HS_C10orf140.
Genevestigator	Q1XH10.
Family and domain databases
InterPro	IPR009061. DNA-bd_dom_put. IPR003380. Transform_Ski. [Graphical view]
Gene3D	G3DSA:3.10.260.20. Transform_Ski. 1 hit.
Pfam	PF02437. Ski_Sno. 1 hit. [Graphical view]
SUPFAM	SSF46955. Putativ_DNA_bind. 1 hit.
ProtoNet	Search...
Other
NextBio	101470.

Entry information

Entry name

DLN1_HUMAN

Accession

Primary (citable) accession number: Q1XH10
Secondary accession number(s): B1ANA5, Q6ZMX4, Q8N3C3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	May 2, 2006
Last modified:	January 25, 2012
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.