Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

SKI/DACH domain-containing protein 1

Gene

SKIDA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
SKI/DACH domain-containing protein 1
Alternative name(s):
Protein DLN-1
Gene namesi
Name:SKIDA1
Synonyms:C10orf140, DLN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:32697. SKIDA1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162377645.

Polymorphism and mutation databases

BioMutaiSKIDA1.
DMDMi121940921.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003285291 – 827SKI/DACH domain-containing protein 1Add BLAST827

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki607Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ1XH10.
PeptideAtlasiQ1XH10.
PRIDEiQ1XH10.

PTM databases

iPTMnetiQ1XH10.
PhosphoSitePlusiQ1XH10.

Expressioni

Gene expression databases

CleanExiHS_C10orf140.

Organism-specific databases

HPAiHPA039208.
HPA040439.

Interactioni

Protein-protein interaction databases

BioGridi132378. 1 interactor.
IntActiQ1XH10. 2 interactors.

Structurei

3D structure databases

ProteinModelPortaliQ1XH10.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi122 – 125Poly-Ala4
Compositional biasi160 – 163Poly-Ala4
Compositional biasi224 – 239Ala-richAdd BLAST16
Compositional biasi256 – 290His-richAdd BLAST35
Compositional biasi293 – 382Ser-richAdd BLAST90
Compositional biasi331 – 368Glu-richAdd BLAST38
Compositional biasi407 – 412Poly-Ala6

Sequence similaritiesi

Belongs to the DACH/dachshund family.Curated

Phylogenomic databases

eggNOGiENOG410II10. Eukaryota.
ENOG41116AE. LUCA.
HOGENOMiHOG000112223.
HOVERGENiHBG063887.
InParanoidiQ1XH10.
PhylomeDBiQ1XH10.

Family and domain databases

Gene3Di3.10.260.20. 1 hit.
InterProiView protein in InterPro
IPR009061. DNA-bd_dom_put.
IPR027971. EPOP.
IPR003380. Transform_Ski.
PfamiView protein in Pfam
PF15223. DUF4584. 1 hit.
PF02437. Ski_Sno. 1 hit.
SUPFAMiSSF46955. SSF46955. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1XH10-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDLKSGFEE VDGVRLGYLI IKGKQMFALS QVFTDLLKNI PRTTVHKRMD
60 70 80 90 100
HLKVKKHHCD LEELRKLKAI NSIAFHAAKC TLISREDVEA LYTSCKTERV
110 120 130 140 150
LKTKRRRVGR ALATKAPPPE RAAAASPRPG FWKDKHQLWR GLSGAARPLP
160 170 180 190 200
ISAQSQRPGA AAARPAAHLP QIFSKYPGSH YPEIVRSPCK PPLNYETAPL
210 220 230 240 250
QGNYVAFPSD PAYFRSLLCS KHPAAAAAAA AAAAAAAGAT CLERFHLVNG
260 270 280 290 300
FCPPPHHHHH HHHHHHHHHH RAQPPQQSHH PPHHHRPQPH LGSFPESCSS
310 320 330 340 350
DSESSSYSDH AANDSDFGSS LSSSSNSVSS EEEEEEGEEE EEEEEEEGGS
360 370 380 390 400
GASDSSEVSS EEEDSSTESD SSSGSSQVSV QSIRFRRTSF CKPPSVQAQA
410 420 430 440 450
NFLYHLASAA AATKPAAFED AGRLPDLKSS VKAESPAEWN LQSWAPKASP
460 470 480 490 500
VYCPASLGSC FAEIRNDRVS EITFPHSEIS NAVKRTDLTI NCLAEGASSP
510 520 530 540 550
SPKTNNAFPQ QRILREARKC LQTTPTTHCA DNNTIAARFL NNDSSGAEAN
560 570 580 590 600
SEKYSKILHC PEFATDLPSS QTDPEVNAAG AAATKAENPC TDTGDKTLPF
610 620 630 640 650
LHNIKIKVED SSANEEYEPH LFTNKLKCEC NDTKGEFYSV TESKEEDALL
660 670 680 690 700
TTAKEGFACP EKETPSLNPL AQSQGLSCTL GSPKPEDGEY KFGARVRKNY
710 720 730 740 750
RTLVLGKRPV LQTPPVKPNL KSARSPRPTG KTETNEGTLD DFTVINRRKK
760 770 780 790 800
VASNVASAVK RPFHFMANFP CPPSLIIGRD GDLWPAYSLN TTKDSQTPHK
810 820
AHPIWKWQLG GSAIPLPPSH KFRKFNS
Length:827
Mass (Da):90,476
Last modified:May 2, 2006 - v1
Checksum:i72A4FA20C06C85EB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti229 – 237Missing in BAD18601 (PubMed:14702039).Curated9
Sequence conflicti347E → EEE in BAD18601 (PubMed:14702039).Curated1
Sequence conflicti347E → EEE in CAD39106 (PubMed:17974005).Curated1
Sequence conflicti769F → K in BAD18601 (PubMed:14702039).Curated1

Polymorphismi

The poly-Ala region of SKIDA1 is highly polymorphic and the number of Ala can vary.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB234866 mRNA. Translation: BAE93016.1.
AK131456 mRNA. Translation: BAD18601.1.
AL358780 Genomic DNA. Translation: CAI13978.2.
AL834446 mRNA. Translation: CAD39106.1.
RefSeqiNP_997254.3. NM_207371.3.
UniGeneiHs.350848.
Hs.694676.

Genome annotation databases

GeneIDi387640.
KEGGihsa:387640.

Similar proteinsi

Entry informationi

Entry nameiSKDA1_HUMAN
AccessioniPrimary (citable) accession number: Q1XH10
Secondary accession number(s): B1ANA5, Q6ZMX4, Q8N3C3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 2, 2006
Last modified: August 30, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families