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Protein

Agouti-signaling protein

Gene

ASIP

Organism
Gorilla gorilla gorilla (Western lowland gorilla)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment) (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Agouti-signaling protein
Short name:
ASP
Alternative name(s):
Agouti switch protein
Gene namesi
Name:ASIP
OrganismiGorilla gorilla gorilla (Western lowland gorilla)
Taxonomic identifieri9595 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeGorilla
Proteomesi
  • UP000001519 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000023519823 – 132Agouti-signaling proteinAdd BLAST110

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi39N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi93 ↔ 108PROSITE-ProRule annotation
Disulfide bondi100 ↔ 114PROSITE-ProRule annotation
Disulfide bondi107 ↔ 125PROSITE-ProRule annotation
Disulfide bondi111 ↔ 132PROSITE-ProRule annotation
Disulfide bondi116 ↔ 123PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9593.ENSGGOP00000026258.

Structurei

3D structure databases

SMRiQ1XGV5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini93 – 132AgoutiPROSITE-ProRule annotationAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi57 – 86Arg/Lys-rich (basic)Add BLAST30

Domaini

The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin.By similarity

Keywords - Domaini

Knottin, Signal

Phylogenomic databases

HOVERGENiHBG050593.
InParanoidiQ1XGV5.

Family and domain databases

Gene3Di4.10.760.10. 1 hit.
InterProiView protein in InterPro
IPR007733. Agouti.
IPR027300. Agouti_dom.
IPR036836. Agouti_dom_sf.
PANTHERiPTHR16551. PTHR16551. 1 hit.
PfamiView protein in Pfam
PF05039. Agouti. 1 hit.
SMARTiView protein in SMART
SM00792. Agouti. 1 hit.
SUPFAMiSSF57055. SSF57055. 1 hit.
PROSITEiView protein in PROSITE
PS60024. AGOUTI_1. 1 hit.
PS51150. AGOUTI_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q1XGV5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVTRLLLAT LLVFLCFFTA NSHLPPEEKL RDDRSLRSNS SVNLLDFPSV
60 70 80 90 100
SIVALNKKSK QIGRKEAEKK RSSKKEASMK KVARPRTPLS APCVATRNSC
110 120 130
KPPAPACCDP CASCQCRFFR SACSCRVLSL NC
Length:132
Mass (Da):14,593
Last modified:May 2, 2006 - v1
Checksum:iBE8BE65C76344791
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB236871 Genomic DNA. Translation: BAE93019.1.

Similar proteinsi

Entry informationi

Entry nameiASIP_GORGO
AccessioniPrimary (citable) accession number: Q1XGV5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 16, 2006
Last sequence update: May 2, 2006
Last modified: October 25, 2017
This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome