Q1XG11 (Q1XG11_STAAU) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Protein ArsC 6 HAMAP MF_01624

Alternative name(s):
Arsenate reductase 6 HAMAP MF_01624
Arsenical pump modifier 6 HAMAP MF_01624
Low molecular weight protein-tyrosine-phosphatase 6 HAMAP MF_01624

Gene names

Name:	arsC EMBL BAE92851.1
Synonyms:	arsC6 HAMAP MF_01624
ORF Names:	SAP013A_019 EMBL ADA61294.1, SAP019A_009 EMBL ADA61555.1, SAP026A_006 EMBL ADA61659.1, SAP033A_029 EMBL ACZ58845.1, SAP054A_023 EMBL ACZ68993.1, SAP055A_009 EMBL ACZ68457.1, SAP065B_014 EMBL ACZ69114.1, SAP067A_025 EMBL ACZ69198.1, SAP075A_025 EMBL ACZ69311.1, SAP076A_030 EMBL ACZ68855.1, SAP077A_037 EMBL ACZ68904.1, SAP078A_025 EMBL ACZ68950.1, SAP084B_011 EMBL ADA80925.1, SAP085C_021 EMBL ADA80420.1, SAP086A_014 EMBL ADA80976.1, SAP087B_032 EMBL ADA81042.1, SAP088A_027 EMBL ADA80466.1, SAP093C_021 EMBL ADA80606.1, SAP095A_007 EMBL ADA79958.1, SAP096A_021 EMBL ADA80004.1, SAP099B_006 EMBL ADA80107.1, SAP102A_019 EMBL ADA80766.1

Encoded on

Plasmid SAP076A Ref.4 Ref.5 EMBL ACZ68855.1
Plasmid pSK62 Ref.4 Ref.5 EMBL ADA80004.1
Plasmid SAP099B Ref.4 Ref.5 EMBL ADA80107.1
Plasmid pWBG752 Ref.4 Ref.5 EMBL ACZ58845.1
Plasmid pSK80 Ref.4 Ref.5 EMBL ADA80606.1
Plasmid pI258 Ref.4 Ref.5 EMBL ADA61294.1
Plasmid pCM05 Ref.4 Ref.5 EMBL ADA61659.1
Plasmid SAP067A Ref.4 Ref.5 EMBL ACZ69198.1
Plasmid pSA1379 Ref.2 Ref.3 Ref.7 EMBL BAE92851.1
Plasmid SAP054A Ref.4 Ref.5 EMBL ACZ68993.1
Plasmid pSK74 Ref.5 Ref.6 EMBL ADA80925.1
Plasmid pSK76 Ref.4 Ref.5 EMBL ADA79958.1
Plasmid pSK60 Ref.5 Ref.6 EMBL ADA80976.1
Plasmid SAP077A Ref.4 Ref.5 EMBL ACZ68904.1
Plasmid SAP078A Ref.4 Ref.5 EMBL ACZ68950.1
Plasmid SAP019A Ref.4 Ref.5 EMBL ADA61555.1
Plasmid SAP055A Ref.4 Ref.5 EMBL ACZ68457.1
Plasmid pSK79 Ref.4 Ref.5 EMBL ADA80466.1
Plasmid SAP065B Ref.4 Ref.5 EMBL ACZ69114.1
Plasmid pSK59 Ref.4 Ref.5 EMBL ADA80420.1
Plasmid EDINA plasmid Ref.8 EMBL BAC54538.1
Plasmid pSK64 Ref.5 Ref.6 EMBL ADA81042.1
Plasmid SAP075A Ref.4 Ref.5 EMBL ACZ69311.1
Plasmid pTZ2162 Ref.1 EMBL BAG12261.1
Plasmid SAP102A Ref.4 Ref.5 EMBL ADA80766.1

Organism

Staphylococcus aureus EMBL BAE92851.1

Taxonomic identifier

1280 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Staphylococcus

Protein attributes

Sequence length	131 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Reduces arsenate [As(V)] to arsenite [As(III)] and dephosphorylates tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Could switch between different functions in different circumstances By similarity. HAMAP MF_01624
Catalytic activity	Arsenate + thioredoxin = arsenite + thioredoxin disulfide + H2O. HAMAP MF_01624 Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. HAMAP MF_01624
Subunit structure	Monomer By similarity. HAMAP MF_01624
Sequence similarities	Belongs to the low molecular weight phosphotyrosine protein phosphatase superfamily. ArsC family. HAMAP MF_01624

Ontologies

Keywords
Biological process	Arsenical resistance HAMAP MF_01624
Domain	Redox-active center HAMAP MF_01624
Molecular function	Hydrolase SAAS SAAS023485 HAMAP MF_01624 Oxidoreductase HAMAP MF_01624 EMBL ACZ58845.1
PTM	Disulfide bond HAMAP MF_01624
Technical term	Plasmid EMBL BAE92851.1
Gene Ontology (GO)
Biological process	response to arsenic-containing substance Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	arsenate reductase (thioredoxin) activity Inferred from electronic annotation. Source: HAMAP protein tyrosine phosphatase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q1XG11 [UniParc]. Last modified May 2, 2006. Version 1. Checksum: 03871148DC433A18	FASTA	131	14,813
	10 20 30 40 50 60 MDKKTIYFIC TGNSCRSQMA EGWGKEILGE GWNVYSAGIE THGVNPKAIE AMKEVDIDIS 70 80 90 100 110 120 NHTSDLIDND ILKQSDLVVT LCSDADNNCP ILPPNVKKEH WGFDDPAGKE WSEFQRVRDE 130 IKLAIEKFKL R

References

[1]	"Characterization of the pTZ2162 encoding multidrug efflux gene qacB from Staphylococcus aureus." Nakaminami H., Noguchi N., Nishijima S., Kurokawa I., Sasatsu M. Plasmid 60:108-117(2008) Cited for: NUCLEOTIDE SEQUENCE. Strain: TPS162 EMBL BAG12261.1.
[2]	"Organization of the antiseptic resistance gene qacA and Tn552-related beta-lactamase genes in multidrug-resistant Staphylococcus haemolyticus strains of animal and human origins." Anthonisen I.-L., Sunde M., Steinum T.M., Sidhu M.S., Sorum H. Antimicrob. Agents Chemother. 46:3606-3612(2002) [PubMed: 12384372] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: IMCJ1379 EMBL BAE92851.1.
[3]	"Whole genome sequencing of meticillin-resistant Staphylococcus aureus." Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L., Oguchi A., Aoki K., Nagai Y., Lian J., Ito T., Kanamori M., Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y. , Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H., Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K., Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H., Hiramatsu K. Lancet (Lond.) 357:1225-1240(2001) Cited for: NUCLEOTIDE SEQUENCE. Strain: IMCJ1379 EMBL BAE92851.1.
[4]	Gill J., Borman J., Shetty J., Hostetler J., Durkin S., Montgomery B. Submitted (AUG-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: 434 EMBL ACZ68457.1, 49 EMBL ACZ68993.1, 879R4RF EMBL ACZ68904.1, A78R1 EMBL ACZ68950.1, B111 EMBL ACZ69311.1, CM05 EMBL ADA61659.1, EMRSA-10 EMBL ACZ69114.1, NRS104 EMBL ADA61555.1, NRS128 EMBL ADA61294.1, PM62 EMBL ACZ69198.1, PM86 EMBL ACZ68855.1, SK1215 EMBL ADA80466.1, SK1271 EMBL ADA80107.1, SK1373 EMBL ADA79958.1, SK1396 EMBL ADA80420.1, SK1397 EMBL ADA80004.1, SK1529 EMBL ADA80606.1, SK6523 EMBL ADA80766.1 and WBG8404 EMBL ACZ58845.1.
[5]	Summers A.O., Shearer J., Wireman J. Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: 434 EMBL ACZ68457.1, 49 EMBL ACZ68993.1, 879R4RF EMBL ACZ68904.1, A78R1 EMBL ACZ68950.1, B111 EMBL ACZ69311.1, CM05 EMBL ADA61659.1, EMRSA-10 EMBL ACZ69114.1, NRS104 EMBL ADA61555.1, NRS128 EMBL ADA61294.1, PM62 EMBL ACZ69198.1, PM86 EMBL ACZ68855.1, SK1011 EMBL ADA80976.1, SK1020 EMBL ADA81042.1, SK1064 EMBL ADA80925.1, SK1215 EMBL ADA80466.1, SK1271 EMBL ADA80107.1, SK1373 EMBL ADA79958.1, SK1396 EMBL ADA80420.1, SK1397 EMBL ADA80004.1, SK1529 EMBL ADA80606.1, SK6523 EMBL ADA80766.1 and WBG8404 EMBL ACZ58845.1.
[6]	Gill J., Borman J., Shetty J., Hostetler J., Durkin S., Montgomery B. Submitted (SEP-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: SK1011 EMBL ADA80976.1, SK1020 EMBL ADA81042.1 and SK1064 EMBL ADA80925.1.
[7]	"Staphylococcus aureus IMCJ1379 plasmid pSA1379, complete sequence." Sekiguchi J., Okuyama S., Oohara T., Kirikae T. Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: IMCJ1379 EMBL BAE92851.1.
[8]	"Complete nucleotide sequence of Staphylococcus aureus E-1 EDINA plasmid." Sugai M., Yamaguchi T., Hayashi T., Nakasone K., Takami H. Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Strain: E-1 EMBL BAC54538.1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	GQ900394 Genomic DNA. Translation: ACZ58845.1. GQ900414 Genomic DNA. Translation: ACZ68457.1. GQ900427 Genomic DNA. Translation: ACZ68855.1. GQ900428 Genomic DNA. Translation: ACZ68904.1. GQ900430 Genomic DNA. Translation: ACZ68950.1. GQ900477 Genomic DNA. Translation: ACZ68993.1. GQ900481 Genomic DNA. Translation: ACZ69114.1. GQ900483 Genomic DNA. Translation: ACZ69198.1. GQ900486 Genomic DNA. Translation: ACZ69311.1. GQ900378 Genomic DNA. Translation: ADA61294.1. GQ900385 Genomic DNA. Translation: ADA61555.1. GQ900387 Genomic DNA. Translation: ADA61659.1. GQ900444 Genomic DNA. Translation: ADA79958.1. GQ900446 Genomic DNA. Translation: ADA80004.1. GQ900449 Genomic DNA. Translation: ADA80107.1. GQ900488 Genomic DNA. Translation: ADA80420.1. GQ900489 Genomic DNA. Translation: ADA80466.1. GQ900492 Genomic DNA. Translation: ADA80606.1. GQ900496 Genomic DNA. Translation: ADA80766.1. GQ915266 Genomic DNA. Translation: ADA80925.1. GQ915267 Genomic DNA. Translation: ADA80976.1. GQ915268 Genomic DNA. Translation: ADA81042.1. AP003089 Genomic DNA. Translation: BAC54538.1. AB255366 Genomic DNA. Translation: BAE92851.1. AB304512 Genomic DNA. Translation: BAG12261.1.
RefSeq	YP_001573918.1. NC_010077.1. YP_001715971.1. NC_010419.1. YP_536862.1. NC_007931.1.
3D structure databases
ProteinModelPortal	Q1XG11.
SMR	Q1XG11. Positions 2-131.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3978621. 5759819. 6155824.
Phylogenomic databases
ProtClustDB	PRK13530.
Family and domain databases
HAMAP	MF_01624. Arsenate_reduct. [Tree]
InterPro	IPR014064. Arsenate_reductase_ArsC. IPR023485. Ptyr_pPase_SF. IPR017867. Tyr_phospatase_low_mol_wt. [Graphical view]
PANTHER	PTHR11717. Low_mwt_PTPase. 1 hit.
Pfam	PF01451. LMWPc. 1 hit. [Graphical view]
SMART	SM00226. LMWPc. 1 hit. [Graphical view]
SUPFAM	SSF52788. Tyr_Pase_low_mol_wt. 1 hit.
TIGRFAMs	TIGR02691. ArsC_pI258_fam. 1 hit.
ProtoNet	Search...

Entry information

Entry name

Q1XG11_STAAU

Accession

Primary (citable) accession number: Q1XG11

Entry history

Integrated into UniProtKB/TrEMBL:	May 2, 2006
Last sequence update:	May 2, 2006
Last modified:	January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)