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Protein

Leucine-rich repeat-containing protein 36

Gene

LRRC36

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 36
Alternative name(s):
ROR gamma-binding protein 70
Gene namesi
Name:LRRC36
Synonyms:RORBP70
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:25615. LRRC36.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000159708.
PharmGKBiPA142671524.

Polymorphism and mutation databases

BioMutaiLRRC36.
DMDMi209572645.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002758551 – 754Leucine-rich repeat-containing protein 36Add BLAST754

Proteomic databases

PaxDbiQ1X8D7.
PeptideAtlasiQ1X8D7.
PRIDEiQ1X8D7.
TopDownProteomicsiQ1X8D7-2. [Q1X8D7-2]

PTM databases

iPTMnetiQ1X8D7.
PhosphoSitePlusiQ1X8D7.

Expressioni

Gene expression databases

BgeeiENSG00000159708.
CleanExiHS_LRRC36.
ExpressionAtlasiQ1X8D7. baseline and differential.
GenevisibleiQ1X8D7. HS.

Organism-specific databases

HPAiHPA055237.
HPA058479.

Interactioni

Protein-protein interaction databases

BioGridi120570. 7 interactors.
IntActiQ1X8D7. 1 interactor.
STRINGi9606.ENSP00000329943.

Structurei

3D structure databases

ProteinModelPortaliQ1X8D7.
SMRiQ1X8D7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati51 – 72LRR 1Add BLAST22
Repeati73 – 94LRR 2Add BLAST22
Domaini107 – 146LRRCTAdd BLAST40

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili600 – 680Sequence analysisAdd BLAST81

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi728 – 731Poly-Ser4

Sequence similaritiesi

Contains 2 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IFK9. Eukaryota.
ENOG411199W. LUCA.
GeneTreeiENSGT00530000063884.
HOGENOMiHOG000060294.
HOVERGENiHBG081929.
InParanoidiQ1X8D7.
KOiK16594.
OMAiFLGPARD.
OrthoDBiEOG091G04WS.
PhylomeDBiQ1X8D7.
TreeFamiTF338646.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q1X8D7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEQWELDEE GIRRLGALTL EQPELVESLS LQGSYAGKIH SIGDAFRNFK
60 70 80 90 100
NLRSLDLSRN LITSLKGIQY LCSLQDLNLY YNNIPSLVEV SRLQPLPFLK
110 120 130 140 150
ELDLRLNPVV RKDTDYRLFA VYTLQTLEKL DDRTVREGER KAAKLHFSQL
160 170 180 190 200
GNSENFLLEV EKSSREKTMK NCVTGESSAS KVSANVDSRI EMDSNKGLFI
210 220 230 240 250
PFPNREIKDS LSTSATQGNG TRDQKLDTFP LGTQTQEVAR REMPSDNHQE
260 270 280 290 300
DEFRHYSPRQ STVRSPEKMT REGYQVSFLD NKSSGSSPEK ELIPKPDTFH
310 320 330 340 350
LTHDASLSKC LDVGDSSQIH PYQLPSDVGL ENYDSCYSQT LSLHGSLGKR
360 370 380 390 400
PQRSKNYQEY SIKPSNDIKT TASHSCGDLL TSLSNPDSST GRLLKLSSDL
410 420 430 440 450
YATTHFNSDP AVLVNVEQQL STSLDDLTPA HGSVPNNAVL GNRTTPLRTL
460 470 480 490 500
LLSPGTSEHR KIFTKRSLSP SKRGFKWKDN ILANLNLKHG FQDATGSEPL
510 520 530 540 550
SSDLGSLHGL AGNHSPPISA RTPHVATVLR QLLELVDKHW NGSGSLLLNK
560 570 580 590 600
KFLGPARDLL LSLVVPAPSQ PRCCSHPEDT MKAFCRRELE LKEAAQLVPN
610 620 630 640 650
DMESLKQKLV RVLEENLILS EKIQQLEEGA AISIVSGQQS HTYDDLLHKN
660 670 680 690 700
QQLTMQVACL NQELAQLKKL EKTVAILHES QRSLVVTNEY LLQQLNKEPK
710 720 730 740 750
GYSGKALLPP EKGHHLGRSS PFGKSTLSSS SPVAHETGQY LIQSVLDAAP

EPGL
Length:754
Mass (Da):83,823
Last modified:October 14, 2008 - v2
Checksum:iE7AD1F4151F340D2
GO
Isoform 2 (identifier: Q1X8D7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-121: Missing.
     122-130: YTLQTLEKL → MLRPRFLPP

Show »
Length:633
Mass (Da):69,950
Checksum:i595A48C0FF2CE1A4
GO
Isoform 3 (identifier: Q1X8D7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MAEQWELDE → MLRPRFLPP
     10-130: Missing.
     499-602: Missing.

Note: No experimental confirmation available.
Show »
Length:529
Mass (Da):58,658
Checksum:i86F6852A5B69AC7E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti43G → S in AAY46032 (Ref. 2) Curated1
Sequence conflicti43G → S in AAH26156 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047015222R → P.Corresponds to variant rs9922085dbSNPEnsembl.1
Natural variantiVAR_047016509G → S.Corresponds to variant rs8052655dbSNPEnsembl.1
Natural variantiVAR_047017744S → G.Corresponds to variant rs16957415dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0229631 – 121Missing in isoform 2. 2 PublicationsAdd BLAST121
Alternative sequenceiVSP_0572641 – 9MAEQWELDE → MLRPRFLPP in isoform 3. 1 Publication9
Alternative sequenceiVSP_05726510 – 130Missing in isoform 3. 1 PublicationAdd BLAST121
Alternative sequenceiVSP_022964122 – 130YTLQTLEKL → MLRPRFLPP in isoform 2. 2 Publications9
Alternative sequenceiVSP_057266499 – 602Missing in isoform 3. 1 PublicationAdd BLAST104

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY313780 mRNA. Translation: AAP81011.1.
AY963267 mRNA. Translation: AAY46032.1.
AK292311 mRNA. Translation: BAF85000.1.
AK301766 mRNA. Translation: BAH13549.1.
AC009061 Genomic DNA. No translation available.
CH471092 Genomic DNA. Translation: EAW83126.1.
BC026156 mRNA. Translation: AAH26156.2.
CCDSiCCDS32467.1. [Q1X8D7-1]
CCDS58474.1. [Q1X8D7-2]
RefSeqiNP_001155047.1. NM_001161575.1. [Q1X8D7-2]
NP_060766.5. NM_018296.5. [Q1X8D7-1]
UniGeneiHs.125139.

Genome annotation databases

EnsembliENST00000329956; ENSP00000329943; ENSG00000159708. [Q1X8D7-1]
ENST00000435835; ENSP00000411122; ENSG00000159708. [Q1X8D7-3]
ENST00000563189; ENSP00000455103; ENSG00000159708. [Q1X8D7-2]
GeneIDi55282.
KEGGihsa:55282.
UCSCiuc002esv.4. human. [Q1X8D7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY313780 mRNA. Translation: AAP81011.1.
AY963267 mRNA. Translation: AAY46032.1.
AK292311 mRNA. Translation: BAF85000.1.
AK301766 mRNA. Translation: BAH13549.1.
AC009061 Genomic DNA. No translation available.
CH471092 Genomic DNA. Translation: EAW83126.1.
BC026156 mRNA. Translation: AAH26156.2.
CCDSiCCDS32467.1. [Q1X8D7-1]
CCDS58474.1. [Q1X8D7-2]
RefSeqiNP_001155047.1. NM_001161575.1. [Q1X8D7-2]
NP_060766.5. NM_018296.5. [Q1X8D7-1]
UniGeneiHs.125139.

3D structure databases

ProteinModelPortaliQ1X8D7.
SMRiQ1X8D7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120570. 7 interactors.
IntActiQ1X8D7. 1 interactor.
STRINGi9606.ENSP00000329943.

PTM databases

iPTMnetiQ1X8D7.
PhosphoSitePlusiQ1X8D7.

Polymorphism and mutation databases

BioMutaiLRRC36.
DMDMi209572645.

Proteomic databases

PaxDbiQ1X8D7.
PeptideAtlasiQ1X8D7.
PRIDEiQ1X8D7.
TopDownProteomicsiQ1X8D7-2. [Q1X8D7-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329956; ENSP00000329943; ENSG00000159708. [Q1X8D7-1]
ENST00000435835; ENSP00000411122; ENSG00000159708. [Q1X8D7-3]
ENST00000563189; ENSP00000455103; ENSG00000159708. [Q1X8D7-2]
GeneIDi55282.
KEGGihsa:55282.
UCSCiuc002esv.4. human. [Q1X8D7-1]

Organism-specific databases

CTDi55282.
GeneCardsiLRRC36.
HGNCiHGNC:25615. LRRC36.
HPAiHPA055237.
HPA058479.
neXtProtiNX_Q1X8D7.
OpenTargetsiENSG00000159708.
PharmGKBiPA142671524.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFK9. Eukaryota.
ENOG411199W. LUCA.
GeneTreeiENSGT00530000063884.
HOGENOMiHOG000060294.
HOVERGENiHBG081929.
InParanoidiQ1X8D7.
KOiK16594.
OMAiFLGPARD.
OrthoDBiEOG091G04WS.
PhylomeDBiQ1X8D7.
TreeFamiTF338646.

Miscellaneous databases

GenomeRNAii55282.
PROiQ1X8D7.

Gene expression databases

BgeeiENSG00000159708.
CleanExiHS_LRRC36.
ExpressionAtlasiQ1X8D7. baseline and differential.
GenevisibleiQ1X8D7. HS.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLRC36_HUMAN
AccessioniPrimary (citable) accession number: Q1X8D7
Secondary accession number(s): A4FTV6
, A6NDE9, A8K8E6, B7Z7B3, Q7Z5K5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 14, 2008
Last modified: November 30, 2016
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.