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Protein

Leucine-rich repeat-containing protein 36

Gene

LRRC36

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 36
Alternative name(s):
ROR gamma-binding protein 70
Gene namesi
Name:LRRC36
Synonyms:RORBP70
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:25615. LRRC36.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142671524.

Polymorphism and mutation databases

BioMutaiLRRC36.
DMDMi209572645.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 754754Leucine-rich repeat-containing protein 36PRO_0000275855Add
BLAST

Proteomic databases

EPDiQ1X8D7.
PaxDbiQ1X8D7.
PRIDEiQ1X8D7.
TopDownProteomicsiQ1X8D7-2. [Q1X8D7-2]

PTM databases

iPTMnetiQ1X8D7.
PhosphoSiteiQ1X8D7.

Expressioni

Gene expression databases

BgeeiQ1X8D7.
CleanExiHS_LRRC36.
ExpressionAtlasiQ1X8D7. baseline and differential.
GenevisibleiQ1X8D7. HS.

Organism-specific databases

HPAiHPA055237.
HPA058479.

Interactioni

Protein-protein interaction databases

BioGridi120570. 7 interactions.
STRINGi9606.ENSP00000329943.

Structurei

3D structure databases

ProteinModelPortaliQ1X8D7.
SMRiQ1X8D7. Positions 22-130, 523-548.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati51 – 7222LRR 1Add
BLAST
Repeati73 – 9422LRR 2Add
BLAST
Domaini107 – 14640LRRCTAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili600 – 68081Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi728 – 7314Poly-Ser

Sequence similaritiesi

Contains 2 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IFK9. Eukaryota.
ENOG411199W. LUCA.
GeneTreeiENSGT00530000063884.
HOGENOMiHOG000060294.
HOVERGENiHBG081929.
InParanoidiQ1X8D7.
KOiK16594.
OMAiFLGPARD.
OrthoDBiEOG7CVPXN.
PhylomeDBiQ1X8D7.
TreeFamiTF338646.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q1X8D7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEQWELDEE GIRRLGALTL EQPELVESLS LQGSYAGKIH SIGDAFRNFK
60 70 80 90 100
NLRSLDLSRN LITSLKGIQY LCSLQDLNLY YNNIPSLVEV SRLQPLPFLK
110 120 130 140 150
ELDLRLNPVV RKDTDYRLFA VYTLQTLEKL DDRTVREGER KAAKLHFSQL
160 170 180 190 200
GNSENFLLEV EKSSREKTMK NCVTGESSAS KVSANVDSRI EMDSNKGLFI
210 220 230 240 250
PFPNREIKDS LSTSATQGNG TRDQKLDTFP LGTQTQEVAR REMPSDNHQE
260 270 280 290 300
DEFRHYSPRQ STVRSPEKMT REGYQVSFLD NKSSGSSPEK ELIPKPDTFH
310 320 330 340 350
LTHDASLSKC LDVGDSSQIH PYQLPSDVGL ENYDSCYSQT LSLHGSLGKR
360 370 380 390 400
PQRSKNYQEY SIKPSNDIKT TASHSCGDLL TSLSNPDSST GRLLKLSSDL
410 420 430 440 450
YATTHFNSDP AVLVNVEQQL STSLDDLTPA HGSVPNNAVL GNRTTPLRTL
460 470 480 490 500
LLSPGTSEHR KIFTKRSLSP SKRGFKWKDN ILANLNLKHG FQDATGSEPL
510 520 530 540 550
SSDLGSLHGL AGNHSPPISA RTPHVATVLR QLLELVDKHW NGSGSLLLNK
560 570 580 590 600
KFLGPARDLL LSLVVPAPSQ PRCCSHPEDT MKAFCRRELE LKEAAQLVPN
610 620 630 640 650
DMESLKQKLV RVLEENLILS EKIQQLEEGA AISIVSGQQS HTYDDLLHKN
660 670 680 690 700
QQLTMQVACL NQELAQLKKL EKTVAILHES QRSLVVTNEY LLQQLNKEPK
710 720 730 740 750
GYSGKALLPP EKGHHLGRSS PFGKSTLSSS SPVAHETGQY LIQSVLDAAP

EPGL
Length:754
Mass (Da):83,823
Last modified:October 14, 2008 - v2
Checksum:iE7AD1F4151F340D2
GO
Isoform 2 (identifier: Q1X8D7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-121: Missing.
     122-130: YTLQTLEKL → MLRPRFLPP

Show »
Length:633
Mass (Da):69,950
Checksum:i595A48C0FF2CE1A4
GO
Isoform 3 (identifier: Q1X8D7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MAEQWELDE → MLRPRFLPP
     10-130: Missing.
     499-602: Missing.

Note: No experimental confirmation available.
Show »
Length:529
Mass (Da):58,658
Checksum:i86F6852A5B69AC7E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti43 – 431G → S in AAY46032 (Ref. 2) Curated
Sequence conflicti43 – 431G → S in AAH26156 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti222 – 2221R → P.
Corresponds to variant rs9922085 [ dbSNP | Ensembl ].
VAR_047015
Natural varianti509 – 5091G → S.
Corresponds to variant rs8052655 [ dbSNP | Ensembl ].
VAR_047016
Natural varianti744 – 7441S → G.
Corresponds to variant rs16957415 [ dbSNP | Ensembl ].
VAR_047017

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 121121Missing in isoform 2. 2 PublicationsVSP_022963Add
BLAST
Alternative sequencei1 – 99MAEQWELDE → MLRPRFLPP in isoform 3. 1 PublicationVSP_057264
Alternative sequencei10 – 130121Missing in isoform 3. 1 PublicationVSP_057265Add
BLAST
Alternative sequencei122 – 1309YTLQTLEKL → MLRPRFLPP in isoform 2. 2 PublicationsVSP_022964
Alternative sequencei499 – 602104Missing in isoform 3. 1 PublicationVSP_057266Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY313780 mRNA. Translation: AAP81011.1.
AY963267 mRNA. Translation: AAY46032.1.
AK292311 mRNA. Translation: BAF85000.1.
AK301766 mRNA. Translation: BAH13549.1.
AC009061 Genomic DNA. No translation available.
CH471092 Genomic DNA. Translation: EAW83126.1.
BC026156 mRNA. Translation: AAH26156.2.
CCDSiCCDS32467.1. [Q1X8D7-1]
CCDS58474.1. [Q1X8D7-2]
RefSeqiNP_001155047.1. NM_001161575.1. [Q1X8D7-2]
NP_060766.5. NM_018296.5. [Q1X8D7-1]
UniGeneiHs.125139.

Genome annotation databases

EnsembliENST00000329956; ENSP00000329943; ENSG00000159708. [Q1X8D7-1]
ENST00000435835; ENSP00000411122; ENSG00000159708. [Q1X8D7-3]
ENST00000563189; ENSP00000455103; ENSG00000159708. [Q1X8D7-2]
GeneIDi55282.
KEGGihsa:55282.
UCSCiuc002esv.4. human. [Q1X8D7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY313780 mRNA. Translation: AAP81011.1.
AY963267 mRNA. Translation: AAY46032.1.
AK292311 mRNA. Translation: BAF85000.1.
AK301766 mRNA. Translation: BAH13549.1.
AC009061 Genomic DNA. No translation available.
CH471092 Genomic DNA. Translation: EAW83126.1.
BC026156 mRNA. Translation: AAH26156.2.
CCDSiCCDS32467.1. [Q1X8D7-1]
CCDS58474.1. [Q1X8D7-2]
RefSeqiNP_001155047.1. NM_001161575.1. [Q1X8D7-2]
NP_060766.5. NM_018296.5. [Q1X8D7-1]
UniGeneiHs.125139.

3D structure databases

ProteinModelPortaliQ1X8D7.
SMRiQ1X8D7. Positions 22-130, 523-548.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120570. 7 interactions.
STRINGi9606.ENSP00000329943.

PTM databases

iPTMnetiQ1X8D7.
PhosphoSiteiQ1X8D7.

Polymorphism and mutation databases

BioMutaiLRRC36.
DMDMi209572645.

Proteomic databases

EPDiQ1X8D7.
PaxDbiQ1X8D7.
PRIDEiQ1X8D7.
TopDownProteomicsiQ1X8D7-2. [Q1X8D7-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329956; ENSP00000329943; ENSG00000159708. [Q1X8D7-1]
ENST00000435835; ENSP00000411122; ENSG00000159708. [Q1X8D7-3]
ENST00000563189; ENSP00000455103; ENSG00000159708. [Q1X8D7-2]
GeneIDi55282.
KEGGihsa:55282.
UCSCiuc002esv.4. human. [Q1X8D7-1]

Organism-specific databases

CTDi55282.
GeneCardsiLRRC36.
HGNCiHGNC:25615. LRRC36.
HPAiHPA055237.
HPA058479.
neXtProtiNX_Q1X8D7.
PharmGKBiPA142671524.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFK9. Eukaryota.
ENOG411199W. LUCA.
GeneTreeiENSGT00530000063884.
HOGENOMiHOG000060294.
HOVERGENiHBG081929.
InParanoidiQ1X8D7.
KOiK16594.
OMAiFLGPARD.
OrthoDBiEOG7CVPXN.
PhylomeDBiQ1X8D7.
TreeFamiTF338646.

Miscellaneous databases

GenomeRNAii55282.
NextBioi35480189.
PROiQ1X8D7.

Gene expression databases

BgeeiQ1X8D7.
CleanExiHS_LRRC36.
ExpressionAtlasiQ1X8D7. baseline and differential.
GenevisibleiQ1X8D7. HS.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a different splice of Homo sapiens hypothetical protein FLJ11004 (FLJ11004)."
    Fang X., Wang H., Xu Z.Y., Yin L.L., Xu M., Li J.M., Zhou Z.M.
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Testis.
  2. Kim Y.-S., Jetten A.M.
    Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
    Tissue: Testis.
  4. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.

Entry informationi

Entry nameiLRC36_HUMAN
AccessioniPrimary (citable) accession number: Q1X8D7
Secondary accession number(s): A4FTV6
, A6NDE9, A8K8E6, B7Z7B3, Q7Z5K5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 14, 2008
Last modified: March 16, 2016
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.