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Q1WV65

- ASSY_LACS1

UniProt

Q1WV65 - ASSY_LACS1

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Protein

Argininosuccinate synthase

Gene
argG, LSL_0306
Organism
Lactobacillus salivarius (strain UCC118)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei86 – 861Citrulline By similarity
Binding sitei116 – 1161ATP; via amide nitrogen By similarity
Binding sitei118 – 1181Aspartate By similarity
Binding sitei122 – 1221Aspartate By similarity
Binding sitei122 – 1221Citrulline By similarity
Binding sitei123 – 1231Aspartate By similarity
Binding sitei126 – 1261Citrulline By similarity
Binding sitei174 – 1741Citrulline By similarity
Binding sitei259 – 2591Citrulline By similarity
Binding sitei271 – 2711Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 179ATP By similarity

GO - Molecular functioni

  1. argininosuccinate synthase activity Source: UniProtKB-HAMAP
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLSAL362948:GJDJ-332-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:LSL_0306
OrganismiLactobacillus salivarius (strain UCC118)
Taxonomic identifieri362948 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000006559: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 403403Argininosuccinate synthaseUniRule annotationPRO_0000263934Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi362948.LSL_0306.

Structurei

3D structure databases

ProteinModelPortaliQ1WV65.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
HOGENOMiHOG000230093.
KOiK01940.
OMAiAPPEEAY.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1WV65-1 [UniParc]FASTAAdd to Basket

« Hide

MEKGKVVLAY SGGLDTSVEI AWLKNKGYDV IACCIDVGEG KDLEAIKEKG    50
LKVGAVESIV IDAKHEFAEE YVLPALQGHA YYENKYPLVS ALSRPLIVKK 100
LVEVAKEHGA TAIAHGCTGK GNDQVRFEVG IHALVPEMKI EDPIRDLHWS 150
REEEIEYAKE NGIPVPISKK SPYSIDENLW GRANECGILE DPWQSAPADA 200
YDRTVALEDT PDTPDVIEIT FDKGVPTKLD GEELPLEELI MKLDKLAGKH 250
GIGRIDHVEN RLVGIKSREV YECPAATVLL AAHKDMEDLT HERDLAHFKP 300
IIEQKLSELI YNGLWFSPLM DAIQAFLAET QKVVNGVVRV KLFKGNVICE 350
GRKSPNSLYS EELATYTSAD QFDQEAAAGF IKLWGLPTQV YAEVMQQNEK 400
NNK 403
Length:403
Mass (Da):44,809
Last modified:May 2, 2006 - v1
Checksum:iDCF4FAA3A72F0FD0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000233 Genomic DNA. Translation: ABD99120.1.
RefSeqiYP_535203.1. NC_007929.1.

Genome annotation databases

EnsemblBacteriaiABD99120; ABD99120; LSL_0306.
GeneIDi3977327.
KEGGilsl:LSL_0306.
PATRICi22277429. VBILacSal43464_0382.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000233 Genomic DNA. Translation: ABD99120.1 .
RefSeqi YP_535203.1. NC_007929.1.

3D structure databases

ProteinModelPortali Q1WV65.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 362948.LSL_0306.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD99120 ; ABD99120 ; LSL_0306 .
GeneIDi 3977327.
KEGGi lsl:LSL_0306.
PATRICi 22277429. VBILacSal43464_0382.

Phylogenomic databases

eggNOGi COG0137.
HOGENOMi HOG000230093.
KOi K01940.
OMAi APPEEAY.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci LSAL362948:GJDJ-332-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: UCC118.

Entry informationi

Entry nameiASSY_LACS1
AccessioniPrimary (citable) accession number: Q1WV65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 12, 2006
Last sequence update: May 2, 2006
Last modified: May 14, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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