ID   GAL1_LACS1              Reviewed;         387 AA.
AC   Q1WUZ4;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2006, sequence version 1.
DT   16-JUN-2009, entry version 22.
DE   RecName: Full=Galactokinase;
DE            EC=2.7.1.6;
DE   AltName: Full=Galactose kinase;
GN   Name=galK; OrderedLocusNames=LSL_0381;
OS   Lactobacillus salivarius subsp. salivarius (strain UCC118).
OC   Bacteria; Firmicutes; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=362948;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16617113; DOI=10.1073/pnas.0511060103;
RA   Claesson M.J., Li Y., Leahy S., Canchaya C., van Pijkeren J.P.,
RA   Cerdeno-Tarraga A.M., Parkhill J., Flynn S., O'Sullivan G.C.,
RA   Collins J.K., Higgins D., Shanahan F., Fitzgerald G.F.,
RA   van Sinderen D., O'Toole P.W.;
RT   "Multireplicon genome architecture of Lactobacillus salivarius.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:6718-6723(2006).
CC   -!- CATALYTIC ACTIVITY: ATP + D-galactose = ADP + alpha-D-galactose 1-
CC       phosphate.
CC   -!- PATHWAY: Carbohydrate metabolism; galactose metabolism.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Potential).
CC   -!- SIMILARITY: Belongs to the GHMP kinase family. GalK subfamily.
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DR   EMBL; CP000233; ABD99191.1; -; Genomic_DNA.
DR   RefSeq; YP_535274.1; -.
DR   GeneID; 3977976; -.
DR   GenomeReviews; CP000233_GR; LSL_0381.
DR   KEGG; lsl:LSL_0381; -.
DR   HOGENOM; Q1WUZ4; -.
DR   OMA; Q1WUZ4; YNDGFVM.
DR   BioCyc; LSAL362948:LSL_0381-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0004335; F:galactokinase activity; IEA:HAMAP.
DR   GO; GO:0046835; P:carbohydrate phosphorylation; IEA:InterPro.
DR   GO; GO:0006012; P:galactose metabolic process; IEA:HAMAP.
DR   HAMAP; MF_00246; -; 1.
DR   InterPro; IPR000705; Galactokinase.
DR   InterPro; IPR019741; Galactokinase_CS.
DR   InterPro; IPR019539; GalKase_gal_bd.
DR   InterPro; IPR006204; GHMP_kinase.
DR   InterPro; IPR013750; GHMP_kinase_C.
DR   InterPro; IPR006203; GHMP_knse_ATP_bd_CS.
DR   InterPro; IPR006206; Mev_galkinase.
DR   InterPro; IPR014721; Ribosomal_S5_D2-type_fold.
DR   Gene3D; G3DSA:3.30.230.10; Ribosomal_S5_D2-type_fold; 1.
DR   Pfam; PF10509; GalKase_gal_bdg; 1.
DR   Pfam; PF08544; GHMP_kinases_C; 1.
DR   Pfam; PF00288; GHMP_kinases_N; 1.
DR   PIRSF; PIRSF000530; Galactokinase; 1.
DR   PRINTS; PR00473; GALCTOKINASE.
DR   PRINTS; PR00959; MEVGALKINASE.
DR   TIGRFAMs; TIGR00131; gal_kin; 1.
DR   PROSITE; PS00106; GALACTOKINASE; 1.
DR   PROSITE; PS00627; GHMP_KINASES_ATP; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Carbohydrate metabolism; Complete proteome; Cytoplasm;
KW   Galactose metabolism; Kinase; Nucleotide-binding; Transferase.
FT   CHAIN         1    387       Galactokinase.
FT                                /FTId=PRO_1000005756.
FT   NP_BIND     122    132       ATP (Potential).
SQ   SEQUENCE   387 AA;  43103 MW;  8EC6CEF99F039B49 CRC64;
     MDKKVINDKF TEIFGEQAEA TFFSPGRINL IGEHTDYNGG HVFPCAISLG TYGAARKRED
     NKLRFYSANF EDLGIIETSL DDLKYDKKDN WVNYAKGMIY FLKETGHDVD KGMDIFIEGN
     IPNGSGLSSS ASLEMLIGVI AQELFNLDID RVDLVKLGME TENKFIGVNS GIMDQFAVGM
     GKQNQAILLD TNTLEYSYAP VDMGNNVIVI MNTNKRRELA DSKYNERRSE CETAVGELQA
     KLDIKTLGEL DAQTFDEYAY LIEDENRLKR ARHAVWENQR TMQAQAALEE GDLEKFGRLV
     NASHVSLEHD YEVTGIELDT LAHTAWKQEG VLGARMTGAG FGGCGIAIVD KDKVEAFKEN
     VGKVYTEKIG YAPAFYIAEI ADGTKVL
//