Reviewed, UniProtKB/Swiss-Prot Q1WUZ4 (GAL1_LACS1)

Names and origin

Protein names

Recommended name:
    Galactokinase
    EC=2.7.1.6
Alternative name(s):
    Galactose kinase

Gene names

Name:	galK
Ordered Locus Names:	LSL_0381

Organism

Lactobacillus salivarius subsp. salivarius (strain UCC118) [Complete proteome] [HAMAP]

Taxonomic identifier

362948 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length	387 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + D-galactose = ADP + alpha-D-galactose 1-phosphate. HAMAP MF_00246
Pathway	Carbohydrate metabolism; galactose metabolism. HAMAP MF_00246
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the GHMP kinase family. GalK subfamily.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Galactose metabolism
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate phosphorylation Inferred from electronic annotation. Source: InterPro galactose metabolic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP galactokinase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 387	387	Galactokinase HAMAP MF_00246		PRO_1000005756
Regions
	Nucleotide binding	122 – 132	11	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q1WUZ4-1 [UniParc]. Last modified May 2, 2006. Version 1. Checksum: 8EC6CEF99F039B49	FASTA	387	43,103
	10 20 30 40 50 60 MDKKVINDKF TEIFGEQAEA TFFSPGRINL IGEHTDYNGG HVFPCAISLG TYGAARKRED 70 80 90 100 110 120 NKLRFYSANF EDLGIIETSL DDLKYDKKDN WVNYAKGMIY FLKETGHDVD KGMDIFIEGN 130 140 150 160 170 180 IPNGSGLSSS ASLEMLIGVI AQELFNLDID RVDLVKLGME TENKFIGVNS GIMDQFAVGM 190 200 210 220 230 240 GKQNQAILLD TNTLEYSYAP VDMGNNVIVI MNTNKRRELA DSKYNERRSE CETAVGELQA 250 260 270 280 290 300 KLDIKTLGEL DAQTFDEYAY LIEDENRLKR ARHAVWENQR TMQAQAALEE GDLEKFGRLV 310 320 330 340 350 360 NASHVSLEHD YEVTGIELDT LAHTAWKQEG VLGARMTGAG FGGCGIAIVD KDKVEAFKEN 370 380 VGKVYTEKIG YAPAFYIAEI ADGTKVL

References

[1]

"Multireplicon genome architecture of Lactobacillus salivarius." Claesson M.J., Li Y., Leahy S., Canchaya C., van Pijkeren J.P., Cerdeno-Tarraga A.M., Parkhill J., Flynn S., O'Sullivan G.C., Collins J.K., Higgins D., Shanahan F., Fitzgerald G.F., van Sinderen D., O'Toole P.W. Proc. Natl. Acad. Sci. U.S.A. 103:6718-6723(2006) [PubMed: 16617113] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000233 Genomic DNA. Translation: ABD99191.1.
RefSeq	YP_535274.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3977976.
GenomeReviews	Gene locus LSL_0381 in contig CP000233_GR.
KEGG	lsl:LSL_0381.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q1WUZ4.
OMA	Q1WUZ4. YNDGFVM.
Enzyme and pathway databases
BioCyc	LSAL362948:LSL_0381-MON.
Family and domain databases
HAMAP	MF_00246. [Tree]
InterPro	IPR000705. Galactokinase. IPR019741. Galactokinase_CS. IPR019539. GalKase_gal_bd. IPR006204. GHMP_kinase. IPR013750. GHMP_kinase_C. IPR006203. GHMP_knse_ATP_bd_CS. IPR006206. Mev_galkinase. IPR014721. Ribosomal_S5_D2-type_fold. [Graphical view]
Gene3D	G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
Pfam	PF10509. GalKase_gal_bdg. 1 hit. PF08544. GHMP_kinases_C. 1 hit. PF00288. GHMP_kinases_N. 1 hit. [Graphical view]
PIRSF	PIRSF000530. Galactokinase. 1 hit.
PRINTS	PR00473. GALCTOKINASE. PR00959. MEVGALKINASE.
TIGRFAMs	TIGR00131. gal_kin. 1 hit.
PROSITE	PS00106. GALACTOKINASE. 1 hit. PS00627. GHMP_KINASES_ATP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GAL1_LACS1

Accession

Primary (citable) accession number: Q1WUZ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 2, 2006
Last modified:	June 16, 2009
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)