Q1WUZ4 (GAL1_LACS1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Galactokinase
EC=2.7.1.6

Alternative name(s):
Galactose kinase

Gene names

Name:	galK
Ordered Locus Names:	LSL_0381

Organism

Lactobacillus salivarius (strain UCC118) [Complete proteome] [HAMAP]

Taxonomic identifier

362948 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length	387 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + D-galactose = ADP + alpha-D-galactose 1-phosphate. HAMAP MF_00246
Pathway	Carbohydrate metabolism; galactose metabolism. HAMAP MF_00246
Subcellular location	Cytoplasm Potential HAMAP MF_00246.
Sequence similarities	Belongs to the GHMP kinase family. GalK subfamily.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Galactose metabolism
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	galactose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW galactokinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 387	387	Galactokinase HAMAP MF_00246		PRO_1000005756
Regions
	Nucleotide binding	122 – 132	11	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q1WUZ4 [UniParc]. Last modified May 2, 2006. Version 1. Checksum: 8EC6CEF99F039B49	FASTA	387	43,103
	10 20 30 40 50 60 MDKKVINDKF TEIFGEQAEA TFFSPGRINL IGEHTDYNGG HVFPCAISLG TYGAARKRED 70 80 90 100 110 120 NKLRFYSANF EDLGIIETSL DDLKYDKKDN WVNYAKGMIY FLKETGHDVD KGMDIFIEGN 130 140 150 160 170 180 IPNGSGLSSS ASLEMLIGVI AQELFNLDID RVDLVKLGME TENKFIGVNS GIMDQFAVGM 190 200 210 220 230 240 GKQNQAILLD TNTLEYSYAP VDMGNNVIVI MNTNKRRELA DSKYNERRSE CETAVGELQA 250 260 270 280 290 300 KLDIKTLGEL DAQTFDEYAY LIEDENRLKR ARHAVWENQR TMQAQAALEE GDLEKFGRLV 310 320 330 340 350 360 NASHVSLEHD YEVTGIELDT LAHTAWKQEG VLGARMTGAG FGGCGIAIVD KDKVEAFKEN 370 380 VGKVYTEKIG YAPAFYIAEI ADGTKVL

References

[1]

"Multireplicon genome architecture of Lactobacillus salivarius." Claesson M.J., Li Y., Leahy S., Canchaya C., van Pijkeren J.P., Cerdeno-Tarraga A.M., Parkhill J., Flynn S., O'Sullivan G.C., Collins J.K., Higgins D., Shanahan F., Fitzgerald G.F., van Sinderen D., O'Toole P.W. Proc. Natl. Acad. Sci. U.S.A. 103:6718-6723(2006) [PubMed: 16617113] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: UCC118.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000233 Genomic DNA. Translation: ABD99191.1.
RefSeq	YP_535274.1. NC_007929.1.
3D structure databases
ProteinModelPortal	Q1WUZ4.
SMR	Q1WUZ4. Positions 6-387.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1WUZ4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3977976.
GenomeReviews	Gene locus LSL_0381 in contig CP000233_GR.
KEGG	lsl:LSL_0381.
PATRIC	22277581. VBILacSal43464_0458.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0153.
HOGENOM	HBG725121.
OMA	YNDGFVM.
PhylomeDB	Q1WUZ4.
ProtClustDB	PRK05322.
Family and domain databases
HAMAP	MF_00246. Galactokinase. [Tree]
InterPro	IPR000705. Galactokinase. IPR022963. Galactokinase_bac. IPR019741. Galactokinase_CS. IPR019539. GalKase_gal-bd. IPR006204. GHMP_kinase. IPR013750. GHMP_kinase_C. IPR006203. GHMP_knse_ATP-bd_CS. IPR006206. Mevalonate/galactokinase. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. [Graphical view]
Gene3D	G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
KO	K00849.
Pfam	PF10509. GalKase_gal_bdg. 1 hit. PF08544. GHMP_kinases_C. 1 hit. PF00288. GHMP_kinases_N. 1 hit. [Graphical view]
PIRSF	PIRSF000530. Galactokinase. 1 hit.
PRINTS	PR00473. GALCTOKINASE. PR00959. MEVGALKINASE.
SUPFAM	SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMs	TIGR00131. Gal_kin. 1 hit.
PROSITE	PS00106. GALACTOKINASE. 1 hit. PS00627. GHMP_KINASES_ATP. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GAL1_LACS1

Accession

Primary (citable) accession number: Q1WUZ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 2, 2006
Last modified:	January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program