Q1WUZ2 (GALT_LACS1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Galactose-1-phosphate uridylyltransferase
Short name=Gal-1-P uridylyltransferase
EC=2.7.7.12

Alternative name(s):
UDP-glucose--hexose-1-phosphate uridylyltransferase

Gene names

Name:	galT
Ordered Locus Names:	LSL_0383

Organism

Lactobacillus salivarius (strain UCC118) [Complete proteome] [HAMAP]

Taxonomic identifier

362948 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length	495 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	UDP-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-galactose. HAMAP MF_00571
Pathway	Carbohydrate metabolism; galactose metabolism. HAMAP MF_00571
Subcellular location	Cytoplasm Potential HAMAP MF_00571.
Sequence similarities	Belongs to the galactose-1-phosphate uridylyltransferase type 2 family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Galactose metabolism
Cellular component	Cytoplasm
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	galactose metabolic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	UDP-glucose:hexose-1-phosphate uridylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 495	495	Galactose-1-phosphate uridylyltransferase HAMAP MF_00571		PRO_1000025025

Sequences

	Sequence		Length	Mass (Da)
	Q1WUZ2 [UniParc]. Last modified May 2, 2006. Version 1. Checksum: 4C22552BF607AF0C	FASTA	495	57,093
	10 20 30 40 50 60 MDDKLLLDTF IKQVIEQENY TELDRNYLYN RILNLVGEGV EKLTTTKNEI IDLKNELVEY 70 80 90 100 110 120 AVQHGKVGET LNEQDCLGAE LMNFITPLPS KVNQDFWQTY QQKSPEEAIQ NFYDLSKRND 130 140 150 160 170 180 YIKTKAIAKN IYFPVETSYG QLEITINLSK PEKDPKQIAL AKKMKASGYP LCQLCMENEG 190 200 210 220 230 240 YQGRINYPAR ANHRIIRFDL DDKQWGFQYS PYAYFNEHCI FLDTIHEPME ITKQTFNNLL 250 260 270 280 290 300 GIIEQFPGYF VGSNADLPIV GGSILTHEHY QGGRHTFAME KAPIETELKF AGYEDIQAGI 310 320 330 340 350 360 VKWPMSVIRL RGNSKEDLVD LADKILKTWR GYSDEEVSVL AESNGEKHHT ITPIARKRDG 370 380 390 400 410 420 QLELDLVLRD NQTSEQYPDG IYHPHPDVQH IKKENIGLIE VMGLAILPPR LKGELQEVEK 430 440 450 460 470 480 YLLGQENKME EYHQVWADDI KQKYSDISQE NVGTIIQQEL GRVFARVLED AGVYKHDETG 490 RMAFKRFVEE VGIVD

References

[1]

"Multireplicon genome architecture of Lactobacillus salivarius." Claesson M.J., Li Y., Leahy S., Canchaya C., van Pijkeren J.P., Cerdeno-Tarraga A.M., Parkhill J., Flynn S., O'Sullivan G.C., Collins J.K., Higgins D., Shanahan F., Fitzgerald G.F., van Sinderen D., O'Toole P.W. Proc. Natl. Acad. Sci. U.S.A. 103:6718-6723(2006) [PubMed: 16617113] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: UCC118.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000233 Genomic DNA. Translation: ABD99193.1.
RefSeq	YP_535276.1. NC_007929.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q1WUZ2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3977978.
GenomeReviews	Gene locus LSL_0383 in contig CP000233_GR.
KEGG	lsl:LSL_0383.
PATRIC	22277585. VBILacSal43464_0460.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG4468.
HOGENOM	HBG337915.
OMA	TWGFQYS.
ProtClustDB	PRK05270.
Family and domain databases
HAMAP	MF_00571. GalP_UDP_trans. [Tree]
InterPro	IPR000766. GalP_uridyl_Trfase_II. IPR023425. GalP_uridyl_Trfase_II_CS. IPR005850. GalP_Utransf_C. IPR005849. GalP_Utransf_N. [Graphical view]
KO	K00965.
Pfam	PF02744. GalP_UDP_tr_C. 1 hit. PF01087. GalP_UDP_transf. 1 hit. [Graphical view]
PIRSF	PIRSF006005. GalT_BS. 1 hit.
TIGRFAMs	TIGR01239. GalT_2. 1 hit.
PROSITE	PS01163. GAL_P_UDP_TRANSF_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GALT_LACS1

Accession

Primary (citable) accession number: Q1WUZ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 2, 2006
Last modified:	January 25, 2012
This is version 36 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program