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Q1WUT3

- SYL_LACS1

UniProt

Q1WUT3 - SYL_LACS1

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Lactobacillus salivarius (strain UCC118)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei579 – 5791ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLSAL362948:GJDJ-507-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:LSL_0442
OrganismiLactobacillus salivarius (strain UCC118)
Taxonomic identifieri362948 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000006559: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 805805Leucine--tRNA ligasePRO_1000009361Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi362948.LSL_0442.

Structurei

3D structure databases

ProteinModelPortaliQ1WUT3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi40 – 5112"HIGH" regionAdd
BLAST
Motifi576 – 5805"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200748.
KOiK01869.
OMAiDKPKYYA.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1WUT3-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSYKHIEIEK KWQRYWEEHK TFKTTEDDDK KNYYALDMFP YPSGQGLHVG
60 70 80 90 100
HPEGYTATDI MARMKRMQGY NVLHPMGWDA FGLPAEQYAL NTGNSPREFT
110 120 130 140 150
KKNVNNFRRQ IKSLGLSYDW DREVNTTDPA YYKWTQWIFE QLYKKGLAYE
160 170 180 190 200
AEVPVNWSPD LGTVVANEEV IDGKTERGGF PVIRKPMRQW VLKITAYADR
210 220 230 240 250
LIDDLDDLDW PEAIKEQQRN WIGRSVGAAI NFPVSGDENT KIEVFSTRPD
260 270 280 290 300
TIFGVAALVL APEHELVKQL TTPEHENEVE AYIEKISHKS DLERTDLAKD
310 320 330 340 350
KTGVFTGSYV VNPVSGEKLP IWIADYVLNS YGTGAVMVVP AHDERDHEFA
360 370 380 390 400
QKFDLPIVQV IEGGDVQKEA YTGDGVHINS DFLNGMDKEE AIDAINNWLE
410 420 430 440 450
ENGVGEKKVN YRLRDWLFSR QRYWGEPIPV IHWEDGETTL VPEDELPLYL
460 470 480 490 500
PKATDIKPSG TGESPLANLD DWVNVVDENG RKGRRETNTM PQWAGSSWYF
510 520 530 540 550
LRYIDPHNNH EIADYEKLKE WLPVNLYVGG AEHAVLHLLY ARFWHKFLYD
560 570 580 590 600
LGVVPTKEPF QKLVNQGMIL GSNHEKMSKS KGNVVNPDDI VEQYGADTLR
610 620 630 640 650
LYEMFMGPLD ASIPWSEEGL GGAHKFINRV WNLLIDENDN LRDRVTTINN
660 670 680 690 700
HDLDKIYNET VKKVTEDYEA MHFNTAISQL MVFVNNAYKA DSLPLEYVEG
710 720 730 740 750
LVKLLSPVVP HITEELWSKL GHVGSIAYAK WPTYDESKLV EDVVEIVVQI
760 770 780 790 800
NGKVRQHLQV SKDASREELQ ALALNDERIK QELADKEVKK VIAVPGKLVS

IVVAK
Length:805
Mass (Da):92,215
Last modified:May 2, 2006 - v1
Checksum:i255216A43873B93C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000233 Genomic DNA. Translation: ABD99252.1.
RefSeqiYP_535335.1. NC_007929.1.

Genome annotation databases

EnsemblBacteriaiABD99252; ABD99252; LSL_0442.
GeneIDi3977437.
KEGGilsl:LSL_0442.
PATRICi22277779. VBILacSal43464_0518.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000233 Genomic DNA. Translation: ABD99252.1 .
RefSeqi YP_535335.1. NC_007929.1.

3D structure databases

ProteinModelPortali Q1WUT3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 362948.LSL_0442.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD99252 ; ABD99252 ; LSL_0442 .
GeneIDi 3977437.
KEGGi lsl:LSL_0442.
PATRICi 22277779. VBILacSal43464_0518.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200748.
KOi K01869.
OMAi DKPKYYA.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci LSAL362948:GJDJ-507-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 2 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 1 hit.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: UCC118.

Entry informationi

Entry nameiSYL_LACS1
AccessioniPrimary (citable) accession number: Q1WUT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 2, 2006
Last modified: November 26, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3