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Q1WUQ7 (DAPEL_LACS1) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
N-acetyldiaminopimelate deacetylase
EC=3.5.1.47
Gene names
Ordered Locus Names:LSL_0469
OrganismLactobacillus salivarius (strain UCC118) [Complete proteome] [HAMAP]
Taxonomic identifier362948 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Lactobacillales › Lactobacillaceae › Lactobacillus ›

Protein attributes

Sequence length381 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the conversion of N-acetyl-diaminopimelate to diaminopimelate and acetate By similarity. HAMAP-Rule MF_01692

Catalytic activity

N-acetyl-LL-2,6-diaminoheptanedioate + H2O = acetate + LL-2,6-diaminoheptanedioate. HAMAP-Rule MF_01692

Pathway

Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (acetylase route): step 3/3. HAMAP-Rule MF_01692

Sequence similarities

Belongs to the peptidase M20A family. N-acetyldiaminopimelate deacetylase subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 381381N-acetyldiaminopimelate deacetylase HAMAP-Rule MF_01692
PRO_0000376765

Sites

Active site711 By similarity
Active site1301Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1WUQ7 [UniParc].

Last modified May 2, 2006. Version 1.
Checksum: D8DA52D1A7278D88

FASTA38142,568
        10         20         30         40         50         60 
MTLQENELIK IRRDLHQIPE IGLEEYETSD YLLKIINGLP QENLEIKRWK TAILVHLNGE 

        70         80         90        100        110        120 
NKNYTIGYRT DIDGLPVEEK TGLPFSSKHE GRMHACGHDI HMTVALGVLS YFASHRPKYN 

       130        140        150        160        170        180 
MTFIFQPAEE NASGGMKLYQ SGELDEWMPD EIYALHDNPQ LPAGTIGCRK GTLFAGTCEI 

       190        200        210        220        230        240 
HVKFIGKSGH AAYPHQANDM VVAGAQFVNQ IQTIVSRNVD PIQSVVVTLG HFSAGTTGNV 

       250        260        270        280        290        300 
ISGVCQIDGT IRALTQENNL LIQKRVRTIA EGIAHSFDCE LEIDLHQGGY YPVENDDNTT 

       310        320        330        340        350        360 
EAFINYMKNE DDVDFVETLP AMTGEDFGYL ISKIPGTMFW LGVDSPYSLH SEYLAPKEES 

       370        380 
IMLGVNAITG YLKNRQESLN K

« Hide

References

[1]"Multireplicon genome architecture of Lactobacillus salivarius."
Claesson M.J., Li Y., Leahy S., Canchaya C., van Pijkeren J.P., Cerdeno-Tarraga A.M., Parkhill J., Flynn S., O'Sullivan G.C., Collins J.K., Higgins D., Shanahan F., Fitzgerald G.F., van Sinderen D., O'Toole P.W.
Proc. Natl. Acad. Sci. U.S.A. 103:6718-6723(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: UCC118.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000233 Genomic DNA. Translation: ABD99278.1.
RefSeqYP_535361.1. NC_007929.1.

3D structure databases

ProteinModelPortalQ1WUQ7.
ModBaseSearch...

Protein-protein interaction databases

STRING362948.LSL_0469.

Protein family/group databases

MEROPSM20.A27.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABD99278; ABD99278; LSL_0469.
GeneID3976845.
KEGGlsl:LSL_0469.
PATRIC22277835. VBILacSal43464_0545.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1473.
HOGENOMHOG000241404.
KOK05823.
OMAASQHEGR.
ProtClustDBCLSK821398.

Enzyme and pathway databases

BioCycLSAL362948:GJDJ-535-MONOMER.
UniPathwayUPA00034; UER00024.

Family and domain databases

HAMAPMF_01692. DapEL.
InterProIPR023905. AcetylDAP_deacetylase.
IPR017439. Amidohydrolase.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
[Graphical view]
PfamPF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view]
PIRSFPIRSF005962. Pept_M20D_amidohydro. 1 hit.
SUPFAMSSF55031. Peptidase_M20_dimer. 1 hit.
TIGRFAMsTIGR01891. amidohydrolases. 1 hit.
PROSITEPS00758. ARGE_DAPE_CPG2_1. False negative.
PS00759. ARGE_DAPE_CPG2_2. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDAPEL_LACS1
AccessionPrimary (citable) accession number: Q1WUQ7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 26, 2009
Last sequence update: May 2, 2006
Last modified: May 1, 2013
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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