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Protein

Ribonuclease 3

Gene

rnc

Organism
Lactobacillus salivarius (strain UCC118)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

Cofactori

Mg2+UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi50MagnesiumUniRule annotation1
Active sitei54UniRule annotation1
Metal bindingi123MagnesiumUniRule annotation1
Active sitei126UniRule annotation1
Metal bindingi126MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease, RNA-binding, rRNA-binding
Biological processmRNA processing, rRNA processing, tRNA processing
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease 3UniRule annotation (EC:3.1.26.3UniRule annotation)
Alternative name(s):
Ribonuclease IIIUniRule annotation
Short name:
RNase IIIUniRule annotation
Gene namesi
Name:rncUniRule annotation
Ordered Locus Names:LSL_0625
OrganismiLactobacillus salivarius (strain UCC118)
Taxonomic identifieri362948 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000006559 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000757711 – 232Ribonuclease 3Add BLAST232

Proteomic databases

PRIDEiQ1WUA0

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi362948.LSL_0625

Structurei

3D structure databases

ProteinModelPortaliQ1WUA0
SMRiQ1WUA0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 137RNase IIIUniRule annotationAdd BLAST132
Domaini163 – 232DRBMUniRule annotationAdd BLAST70

Sequence similaritiesi

Belongs to the ribonuclease III family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108ZBM Bacteria
COG0571 LUCA
HOGENOMiHOG000246808
KOiK03685
OMAiLTHKSCK
OrthoDBiPOG091H00R1

Family and domain databases

CDDicd00593 RIBOc, 1 hit
Gene3Di1.10.1520.10, 1 hit
HAMAPiMF_00104 RNase_III, 1 hit
InterProiView protein in InterPro
IPR014720 dsRBD_dom
IPR011907 RNase_III
IPR000999 RNase_III_dom
IPR036389 RNase_III_sf
PfamiView protein in Pfam
PF00035 dsrm, 1 hit
PF14622 Ribonucleas_3_3, 1 hit
SMARTiView protein in SMART
SM00358 DSRM, 1 hit
SM00535 RIBOc, 1 hit
SUPFAMiSSF69065 SSF69065, 1 hit
TIGRFAMsiTIGR02191 RNaseIII, 1 hit
PROSITEiView protein in PROSITE
PS50137 DS_RBD, 1 hit
PS50142 RNASE_3_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q1WUA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIEGLQEMLK RDFNITFKDV DLLDAAFTHA SYVNETPERK KKLKYYERIE
60 70 80 90 100
FLGDAVMQLC VSEYIYEHYP EMPEGKMSRL RAAMVRADSF SKFAIECHFN
110 120 130 140 150
EYIRLGKGEE KGNARQRPSL LCDIFESFIG ALYLDQGKDE VVRFISKVIF
160 170 180 190 200
PKLELGWFDH MMDNKTELQE VLQQNGECKI KYNEVNVTGP DNERVYTMNV
210 220 230
VVNNEVMGEG TGRTKKAAEQ MAAYQALKKL RK
Length:232
Mass (Da):26,957
Last modified:May 2, 2006 - v1
Checksum:i45FA600319C48EC3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000233 Genomic DNA Translation: ABD99435.1
RefSeqiWP_003701755.1, NC_007929.1
YP_535518.1, NC_007929.1

Genome annotation databases

EnsemblBacteriaiABD99435; ABD99435; LSL_0625
GeneIDi3977183
KEGGilsl:LSL_0625
PATRICifig|362948.14.peg.705

Similar proteinsi

Entry informationi

Entry nameiRNC_LACS1
AccessioniPrimary (citable) accession number: Q1WUA0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 2, 2006
Last modified: May 23, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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