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Q1WU76

- DEF_LACS1

UniProt

Q1WU76 - DEF_LACS1

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Protein
Peptide deformylase
Gene
def, LSL_0649
Organism
Lactobacillus salivarius (strain UCC118)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions By similarity.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotation

Cofactori

Binds 1 Fe2+ ion By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi113 – 1131Iron By similarity
Metal bindingi156 – 1561Iron By similarity
Active sitei157 – 1571 By similarity
Metal bindingi160 – 1601Iron By similarity

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. peptide deformylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. translation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciLSAL362948:GJDJ-721-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylase (EC:3.5.1.88)
Short name:
PDF
Alternative name(s):
Polypeptide deformylase
Gene namesi
Name:def
Ordered Locus Names:LSL_0649
OrganismiLactobacillus salivarius (strain UCC118)
Taxonomic identifieri362948 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000006559: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 186186Peptide deformylaseUniRule annotation
PRO_0000301049Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi362948.LSL_0649.

Structurei

3D structure databases

ProteinModelPortaliQ1WU76.
SMRiQ1WU76. Positions 1-186.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0242.
HOGENOMiHOG000243507.
KOiK01462.
OMAiNDPENET.
OrthoDBiEOG6PZXGQ.

Family and domain databases

Gene3Di3.90.45.10. 1 hit.
HAMAPiMF_00163. Pep_deformylase.
InterProiIPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view]
PANTHERiPTHR10458. PTHR10458. 1 hit.
PfamiPF01327. Pep_deformylase. 1 hit.
[Graphical view]
PIRSFiPIRSF004749. Pep_def. 1 hit.
PRINTSiPR01576. PDEFORMYLASE.
SUPFAMiSSF56420. SSF56420. 1 hit.
TIGRFAMsiTIGR00079. pept_deformyl. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1WU76-1 [UniParc]FASTAAdd to Basket

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MITMDNIIRD GNPTLRARAK AIEFPLSEED KKLAHDMMEF LENSQNPEIA    50
KKYHLRAGVG LAAPQVDVSK RMTAVLVPGI EDDDEPIFKH VLINPTILSE 100
SVQLAALGEG EGCLSVDRDI PGYVPRHDRI KLRWYDLDGN KHVERLRDYP 150
AIVVQHEIDH LNGILFYDHI NKEQPLTVPE GTIILE 186
Length:186
Mass (Da):21,063
Last modified:May 2, 2006 - v1
Checksum:i4373DDEDAFBD7D8B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000233 Genomic DNA. Translation: ABD99459.1.
RefSeqiYP_535542.1. NC_007929.1.

Genome annotation databases

EnsemblBacteriaiABD99459; ABD99459; LSL_0649.
GeneIDi3977413.
KEGGilsl:LSL_0649.
PATRICi22278207. VBILacSal43464_0729.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000233 Genomic DNA. Translation: ABD99459.1 .
RefSeqi YP_535542.1. NC_007929.1.

3D structure databases

ProteinModelPortali Q1WU76.
SMRi Q1WU76. Positions 1-186.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 362948.LSL_0649.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD99459 ; ABD99459 ; LSL_0649 .
GeneIDi 3977413.
KEGGi lsl:LSL_0649.
PATRICi 22278207. VBILacSal43464_0729.

Phylogenomic databases

eggNOGi COG0242.
HOGENOMi HOG000243507.
KOi K01462.
OMAi NDPENET.
OrthoDBi EOG6PZXGQ.

Enzyme and pathway databases

BioCyci LSAL362948:GJDJ-721-MONOMER.

Family and domain databases

Gene3Di 3.90.45.10. 1 hit.
HAMAPi MF_00163. Pep_deformylase.
InterProi IPR000181. Fmet_deformylase.
IPR023635. Peptide_deformylase.
[Graphical view ]
PANTHERi PTHR10458. PTHR10458. 1 hit.
Pfami PF01327. Pep_deformylase. 1 hit.
[Graphical view ]
PIRSFi PIRSF004749. Pep_def. 1 hit.
PRINTSi PR01576. PDEFORMYLASE.
SUPFAMi SSF56420. SSF56420. 1 hit.
TIGRFAMsi TIGR00079. pept_deformyl. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: UCC118.

Entry informationi

Entry nameiDEF_LACS1
AccessioniPrimary (citable) accession number: Q1WU76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 2, 2006
Last modified: May 14, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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