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Q1WU55

- PUR9_LACS1

UniProt

Q1WU55 - PUR9_LACS1

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Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Lactobacillus salivarius (strain UCC118)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
  2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transferase

Keywords - Biological processi

Purine biosynthesis

Enzyme and pathway databases

BioCyciLSAL362948:GJDJ-742-MONOMER.
UniPathwayiUPA00074; UER00133.
UPA00074; UER00135.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional purine biosynthesis protein PurHUniRule annotation
Including the following 2 domains:
Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
Alternative name(s):
AICAR transformylaseUniRule annotation
IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
Alternative name(s):
ATICUniRule annotation
IMP synthaseUniRule annotation
InosinicaseUniRule annotation
Gene namesi
Name:purHUniRule annotation
Ordered Locus Names:LSL_0670
OrganismiLactobacillus salivarius (strain UCC118)
Taxonomic identifieri362948 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000006559: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 512512Bifunctional purine biosynthesis protein PurHPRO_1000018902Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi362948.LSL_0670.

Structurei

3D structure databases

ProteinModelPortaliQ1WU55.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

Sequence similaritiesi

Belongs to the PurH family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0138.
HOGENOMiHOG000230373.
KOiK00602.
OMAiGIGQADN.
OrthoDBiEOG6QCDFF.

Family and domain databases

Gene3Di3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPiMF_00139. PurH.
InterProiIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERiPTHR11692. PTHR11692. 1 hit.
PfamiPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMiSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsiTIGR00355. purH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q1WU55-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKRALVSVSD KNNLVPFVKK LVEHDFEIVS TGGTKKYLDE AGIKTISVEE
60 70 80 90 100
VTHFPEILDG RVKTLNPYIH GGLLARRELP EHMETLKEQN ITPIDLVCVN
110 120 130 140 150
LYPFKQTIEN PEVTLENAIE NIDIGGPSML RSAAKNYRDV VVVVDADDYE
160 170 180 190 200
GLEKELDENG EISLETRFKL SAKTFRHTAA YDALIADYLS KQAGEDNPEK
210 220 230 240 250
LTLTYDLISS MRYGENSHQK AWFYEDAMPK AYSITQAKQL NGKKLSFNNI
260 270 280 290 300
RDADAAIRAV REFDGPTVVA LKHMNPCGIG QADNIELAWD RAYEADSISI
310 320 330 340 350
FGGVIALNRK VDLATAEKMH KLFLEIIIAP EFDADALEVL SKKKNLRLLQ
360 370 380 390 400
LDFTKKDEDV RDETVSIMGG LLRQEQDVID ENPKNWEVVT ENAPSDSQLE
410 420 430 440 450
TLLFAWKAVK HTKSNAIVVA NDERTLGIGA GQPNRIDSTK IAIKHAGDSL
460 470 480 490 500
NDKAVLASDA FFPMDDCVQY AAEHGIKAIV QPGGSIRDKD SIAMANKYGV
510
AMVFTGVRHF RH
Length:512
Mass (Da):57,064
Last modified:May 2, 2006 - v1
Checksum:iC538142AC324BF2C
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000233 Genomic DNA. Translation: ABD99480.1.
RefSeqiYP_535563.1. NC_007929.1.

Genome annotation databases

EnsemblBacteriaiABD99480; ABD99480; LSL_0670.
GeneIDi3976898.
KEGGilsl:LSL_0670.
PATRICi22278249. VBILacSal43464_0750.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000233 Genomic DNA. Translation: ABD99480.1 .
RefSeqi YP_535563.1. NC_007929.1.

3D structure databases

ProteinModelPortali Q1WU55.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 362948.LSL_0670.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD99480 ; ABD99480 ; LSL_0670 .
GeneIDi 3976898.
KEGGi lsl:LSL_0670.
PATRICi 22278249. VBILacSal43464_0750.

Phylogenomic databases

eggNOGi COG0138.
HOGENOMi HOG000230373.
KOi K00602.
OMAi GIGQADN.
OrthoDBi EOG6QCDFF.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00133 .
UPA00074 ; UER00135 .
BioCyci LSAL362948:GJDJ-742-MONOMER.

Family and domain databases

Gene3Di 3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPi MF_00139. PurH.
InterProi IPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view ]
PANTHERi PTHR11692. PTHR11692. 1 hit.
Pfami PF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view ]
PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view ]
SUPFAMi SSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsi TIGR00355. purH. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: UCC118.

Entry informationi

Entry nameiPUR9_LACS1
AccessioniPrimary (citable) accession number: Q1WU55
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 2, 2006
Last modified: October 1, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3