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Q1WU55 (PUR9_LACS1) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional purine biosynthesis protein PurH

Including the following 2 domains:

  1. Phosphoribosylaminoimidazolecarboxamide formyltransferase
    EC=2.1.2.3
    Alternative name(s):
    AICAR transformylase
  2. IMP cyclohydrolase
    EC=3.5.4.10
    Alternative name(s):
    ATIC
    IMP synthase
    Inosinicase
Gene names
Name:purH
Ordered Locus Names:LSL_0670
OrganismLactobacillus salivarius (strain UCC118) [Complete proteome] [HAMAP]
Taxonomic identifier362948 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length512 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. HAMAP-Rule MF_00139

Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.

Domain

The IMP cyclohydrolase activity resides in the N-terminal region By similarity. HAMAP-Rule MF_00139

Sequence similarities

Belongs to the PurH family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 512512Bifunctional purine biosynthesis protein PurH HAMAP-Rule MF_00139
PRO_1000018902

Sequences

Sequence LengthMass (Da)Tools
Q1WU55 [UniParc].

Last modified May 2, 2006. Version 1.
Checksum: C538142AC324BF2C

FASTA51257,064
        10         20         30         40         50         60 
MKRALVSVSD KNNLVPFVKK LVEHDFEIVS TGGTKKYLDE AGIKTISVEE VTHFPEILDG 

        70         80         90        100        110        120 
RVKTLNPYIH GGLLARRELP EHMETLKEQN ITPIDLVCVN LYPFKQTIEN PEVTLENAIE 

       130        140        150        160        170        180 
NIDIGGPSML RSAAKNYRDV VVVVDADDYE GLEKELDENG EISLETRFKL SAKTFRHTAA 

       190        200        210        220        230        240 
YDALIADYLS KQAGEDNPEK LTLTYDLISS MRYGENSHQK AWFYEDAMPK AYSITQAKQL 

       250        260        270        280        290        300 
NGKKLSFNNI RDADAAIRAV REFDGPTVVA LKHMNPCGIG QADNIELAWD RAYEADSISI 

       310        320        330        340        350        360 
FGGVIALNRK VDLATAEKMH KLFLEIIIAP EFDADALEVL SKKKNLRLLQ LDFTKKDEDV 

       370        380        390        400        410        420 
RDETVSIMGG LLRQEQDVID ENPKNWEVVT ENAPSDSQLE TLLFAWKAVK HTKSNAIVVA 

       430        440        450        460        470        480 
NDERTLGIGA GQPNRIDSTK IAIKHAGDSL NDKAVLASDA FFPMDDCVQY AAEHGIKAIV 

       490        500        510 
QPGGSIRDKD SIAMANKYGV AMVFTGVRHF RH 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000233 Genomic DNA. Translation: ABD99480.1.
RefSeqYP_535563.1. NC_007929.1.

3D structure databases

ProteinModelPortalQ1WU55.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING362948.LSL_0670.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABD99480; ABD99480; LSL_0670.
GeneID3976898.
KEGGlsl:LSL_0670.
PATRIC22278249. VBILacSal43464_0750.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0138.
HOGENOMHOG000230373.
KOK00602.
OMAGIGQADN.
OrthoDBEOG6QCDFF.

Enzyme and pathway databases

BioCycLSAL362948:GJDJ-742-MONOMER.
UniPathwayUPA00074; UER00133.
UPA00074; UER00135.

Family and domain databases

Gene3D3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPMF_00139. PurH.
InterProIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERPTHR11692. PTHR11692. 1 hit.
PfamPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsTIGR00355. purH. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR9_LACS1
AccessionPrimary (citable) accession number: Q1WU55
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 2, 2006
Last modified: May 14, 2014
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways