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Q1WU17

- TYSY_LACS1

UniProt

Q1WU17 - TYSY_LACS1

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Protein

Thymidylate synthase

Gene

thyA

Organism
Lactobacillus salivarius (strain UCC118)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Provides the sole de novo source of dTMP for DNA biosynthesis.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei200 – 2001UniRule annotation

GO - Molecular functioni

  1. thymidylate synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dTMP biosynthetic process Source: UniProtKB-HAMAP
  2. dTTP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Enzyme and pathway databases

BioCyciLSAL362948:GJDJ-781-MONOMER.
UniPathwayiUPA00575.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate synthaseUniRule annotation (EC:2.1.1.45UniRule annotation)
Short name:
TSUniRule annotation
Short name:
TSaseUniRule annotation
Gene namesi
Name:thyAUniRule annotation
Ordered Locus Names:LSL_0708
OrganismiLactobacillus salivarius (strain UCC118)
Taxonomic identifieri362948 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000006559: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Thymidylate synthasePRO_1000000618Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi362948.LSL_0708.

Structurei

3D structure databases

ProteinModelPortaliQ1WU17.
SMRiQ1WU17. Positions 3-318.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0207.
HOGENOMiHOG000257899.
KOiK00560.
OMAiAQWRHWE.
OrthoDBiEOG6K6V53.

Family and domain databases

Gene3Di3.30.572.10. 2 hits.
HAMAPiMF_00008. Thymidy_synth_bact.
InterProiIPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view]
PfamiPF00303. Thymidylat_synt. 1 hit.
[Graphical view]
PRINTSiPR00108. THYMDSNTHASE.
SUPFAMiSSF55831. SSF55831. 1 hit.
TIGRFAMsiTIGR03284. thym_sym. 1 hit.
PROSITEiPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1WU17 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSIVEEPYLQ LIRDILEKGH EKSDRTGTGT KSLFGYQMRF NLAEGFPLLT
60 70 80 90 100
TKKVPFGLIK SELLWFLRGD TNIRFLLEHN NHIWDEWAFK NWVESDEYHG
110 120 130 140 150
PDMTNFGLRA QEDDNFNKVY QDEKKKFCQK IVEDQEFANK FGNLGDVYGA
160 170 180 190 200
QWRHWQTRNG ETIDQIKDVI ETIKNNPDSR RMIVTAWNPE DVPLSALPPC
210 220 230 240 250
HTLFQFYVND GKLSCQLYQR SADVFLGVPF NIASYALLTH MIARETGLEV
260 270 280 290 300
GEFVHTLGDA HIYLNHLDQV NEQLQRKPND APTLWLNPEK KNIMDFEMED
310
IKVKNYHSHS AIKAPVAV
Length:318
Mass (Da):36,978
Last modified:May 2, 2006 - v1
Checksum:iCC5A694F55B493C7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000233 Genomic DNA. Translation: ABD99518.1.
RefSeqiYP_535601.1. NC_007929.1.

Genome annotation databases

EnsemblBacteriaiABD99518; ABD99518; LSL_0708.
GeneIDi3976937.
KEGGilsl:LSL_0708.
PATRICi22278325. VBILacSal43464_0787.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000233 Genomic DNA. Translation: ABD99518.1 .
RefSeqi YP_535601.1. NC_007929.1.

3D structure databases

ProteinModelPortali Q1WU17.
SMRi Q1WU17. Positions 3-318.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 362948.LSL_0708.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABD99518 ; ABD99518 ; LSL_0708 .
GeneIDi 3976937.
KEGGi lsl:LSL_0708.
PATRICi 22278325. VBILacSal43464_0787.

Phylogenomic databases

eggNOGi COG0207.
HOGENOMi HOG000257899.
KOi K00560.
OMAi AQWRHWE.
OrthoDBi EOG6K6V53.

Enzyme and pathway databases

UniPathwayi UPA00575 .
BioCyci LSAL362948:GJDJ-781-MONOMER.

Family and domain databases

Gene3Di 3.30.572.10. 2 hits.
HAMAPi MF_00008. Thymidy_synth_bact.
InterProi IPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view ]
Pfami PF00303. Thymidylat_synt. 1 hit.
[Graphical view ]
PRINTSi PR00108. THYMDSNTHASE.
SUPFAMi SSF55831. SSF55831. 1 hit.
TIGRFAMsi TIGR03284. thym_sym. 1 hit.
PROSITEi PS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: UCC118.

Entry informationi

Entry nameiTYSY_LACS1
AccessioniPrimary (citable) accession number: Q1WU17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 2, 2006
Last modified: October 29, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3