Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q1WTW0

- FTHS_LACS1

UniProt

Q1WTW0 - FTHS_LACS1

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Lactobacillus salivarius (strain UCC118)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 51 (01 Oct 2014)
      Sequence version 1 (02 May 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi62 – 698ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciLSAL362948:GJDJ-919-MONOMER.
    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:LSL_0842
    OrganismiLactobacillus salivarius (strain UCC118)
    Taxonomic identifieri362948 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000006559: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 552552Formate--tetrahydrofolate ligasePRO_0000293043Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi362948.LSL_0842.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1WTW0.
    SMRiQ1WTW0. Positions 3-550.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    HOGENOMiHOG000040280.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q1WTW0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKDIEIAQKS EMLPITEVAQ KVGLTADEIE QYGKYKAKIS LPLSAREQTK    50
    RKLVLVTAIN PTPAGEGKST VTVGLGDAFS LLNKKVMIAL REPSLGPVMG 100
    MKGGATGGGY SQVVPMEDIN LHFTGDMHAL TTANNTLAAL IDNHIYQGNK 150
    LNIDQRRVIW KRVLDINDRA LRHVVIGLGG ATQGIPREDG FDITVASELM 200
    AILCLSKDIS DLKKRIGQIV IGYNFDKEPV TVDQLGVTGA ITLLLKDACK 250
    PNLVQTLAHT PAIVHGGPFA NIAHGCNSVL ATQTALNLAD YTITEAGFGA 300
    DLGAEKFLDI KTPVLGKTPD TIVIVATARA LKMNGGVAKD NLDEENVAAV 350
    EQGFANLKKH IQSMKRYNVP VVVAINKFTQ DTDAELAKIV ELCEQDDTKA 400
    IVADVWAKGG EGATELAKAV IESCDNDQEF TRLYNSDDSV EEKINKIVTE 450
    IYGGDGVEFS AKAKRQLRQF EKLGWNHLPV CMAKTQYSLS DNAKVLGAPK 500
    GFKIHVREFV PKLGAQFLVA LTGNILTMPG LPKVPAADGM DVDENGKISG 550
    LY 552
    Length:552
    Mass (Da):59,469
    Last modified:May 2, 2006 - v1
    Checksum:i60151621C7ABA759
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000233 Genomic DNA. Translation: ABD99652.1.
    RefSeqiYP_535735.1. NC_007929.1.

    Genome annotation databases

    EnsemblBacteriaiABD99652; ABD99652; LSL_0842.
    GeneIDi3977772.
    KEGGilsl:LSL_0842.
    PATRICi22278587. VBILacSal43464_0916.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000233 Genomic DNA. Translation: ABD99652.1 .
    RefSeqi YP_535735.1. NC_007929.1.

    3D structure databases

    ProteinModelPortali Q1WTW0.
    SMRi Q1WTW0. Positions 3-550.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 362948.LSL_0842.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABD99652 ; ABD99652 ; LSL_0842 .
    GeneIDi 3977772.
    KEGGi lsl:LSL_0842.
    PATRICi 22278587. VBILacSal43464_0916.

    Phylogenomic databases

    eggNOGi COG2759.
    HOGENOMi HOG000040280.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .
    BioCyci LSAL362948:GJDJ-919-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: UCC118.

    Entry informationi

    Entry nameiFTHS_LACS1
    AccessioniPrimary (citable) accession number: Q1WTW0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 10, 2007
    Last sequence update: May 2, 2006
    Last modified: October 1, 2014
    This is version 51 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3