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Q1WTW0 (FTHS_LACS1) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:LSL_0842
OrganismLactobacillus salivarius (strain UCC118) [Complete proteome] [HAMAP]
Taxonomic identifier362948 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

Protein attributes

Sequence length552 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Ontologies

Keywords
   Biological processOne-carbon metabolism
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processfolic acid-containing compound biosynthetic process

Inferred from electronic annotation. Source: InterPro

tetrahydrofolate interconversion

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

formate-tetrahydrofolate ligase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 552552Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000293043

Regions

Nucleotide binding62 – 698ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q1WTW0 [UniParc].

Last modified May 2, 2006. Version 1.
Checksum: 60151621C7ABA759

FASTA55259,469
        10         20         30         40         50         60 
MKDIEIAQKS EMLPITEVAQ KVGLTADEIE QYGKYKAKIS LPLSAREQTK RKLVLVTAIN 

        70         80         90        100        110        120 
PTPAGEGKST VTVGLGDAFS LLNKKVMIAL REPSLGPVMG MKGGATGGGY SQVVPMEDIN 

       130        140        150        160        170        180 
LHFTGDMHAL TTANNTLAAL IDNHIYQGNK LNIDQRRVIW KRVLDINDRA LRHVVIGLGG 

       190        200        210        220        230        240 
ATQGIPREDG FDITVASELM AILCLSKDIS DLKKRIGQIV IGYNFDKEPV TVDQLGVTGA 

       250        260        270        280        290        300 
ITLLLKDACK PNLVQTLAHT PAIVHGGPFA NIAHGCNSVL ATQTALNLAD YTITEAGFGA 

       310        320        330        340        350        360 
DLGAEKFLDI KTPVLGKTPD TIVIVATARA LKMNGGVAKD NLDEENVAAV EQGFANLKKH 

       370        380        390        400        410        420 
IQSMKRYNVP VVVAINKFTQ DTDAELAKIV ELCEQDDTKA IVADVWAKGG EGATELAKAV 

       430        440        450        460        470        480 
IESCDNDQEF TRLYNSDDSV EEKINKIVTE IYGGDGVEFS AKAKRQLRQF EKLGWNHLPV 

       490        500        510        520        530        540 
CMAKTQYSLS DNAKVLGAPK GFKIHVREFV PKLGAQFLVA LTGNILTMPG LPKVPAADGM 

       550 
DVDENGKISG LY 

« Hide

References

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000233 Genomic DNA. Translation: ABD99652.1.
RefSeqYP_535735.1. NC_007929.1.

3D structure databases

ProteinModelPortalQ1WTW0.
SMRQ1WTW0. Positions 3-550.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING362948.LSL_0842.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABD99652; ABD99652; LSL_0842.
GeneID3977772.
KEGGlsl:LSL_0842.
PATRIC22278587. VBILacSal43464_0916.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2759.
HOGENOMHOG000040280.
KOK01938.
OMALKHHGGV.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

BioCycLSAL362948:GJDJ-919-MONOMER.
UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_LACS1
AccessionPrimary (citable) accession number: Q1WTW0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: May 2, 2006
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways