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Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Lactobacillus salivarius (strain UCC118)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi62 – 698ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciLSAL362948:GJDJ-919-MONOMER.
UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:LSL_0842
OrganismiLactobacillus salivarius (strain UCC118)
Taxonomic identifieri362948 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
ProteomesiUP000006559 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 552552Formate--tetrahydrofolate ligasePRO_0000293043Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi362948.LSL_0842.

Structurei

3D structure databases

ProteinModelPortaliQ1WTW0.
SMRiQ1WTW0. Positions 3-550.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiCMVKTHL.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q1WTW0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKDIEIAQKS EMLPITEVAQ KVGLTADEIE QYGKYKAKIS LPLSAREQTK
60 70 80 90 100
RKLVLVTAIN PTPAGEGKST VTVGLGDAFS LLNKKVMIAL REPSLGPVMG
110 120 130 140 150
MKGGATGGGY SQVVPMEDIN LHFTGDMHAL TTANNTLAAL IDNHIYQGNK
160 170 180 190 200
LNIDQRRVIW KRVLDINDRA LRHVVIGLGG ATQGIPREDG FDITVASELM
210 220 230 240 250
AILCLSKDIS DLKKRIGQIV IGYNFDKEPV TVDQLGVTGA ITLLLKDACK
260 270 280 290 300
PNLVQTLAHT PAIVHGGPFA NIAHGCNSVL ATQTALNLAD YTITEAGFGA
310 320 330 340 350
DLGAEKFLDI KTPVLGKTPD TIVIVATARA LKMNGGVAKD NLDEENVAAV
360 370 380 390 400
EQGFANLKKH IQSMKRYNVP VVVAINKFTQ DTDAELAKIV ELCEQDDTKA
410 420 430 440 450
IVADVWAKGG EGATELAKAV IESCDNDQEF TRLYNSDDSV EEKINKIVTE
460 470 480 490 500
IYGGDGVEFS AKAKRQLRQF EKLGWNHLPV CMAKTQYSLS DNAKVLGAPK
510 520 530 540 550
GFKIHVREFV PKLGAQFLVA LTGNILTMPG LPKVPAADGM DVDENGKISG

LY
Length:552
Mass (Da):59,469
Last modified:May 2, 2006 - v1
Checksum:i60151621C7ABA759
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000233 Genomic DNA. Translation: ABD99652.1.
RefSeqiWP_011475989.1. NC_007929.1.
YP_535735.1. NC_007929.1.

Genome annotation databases

EnsemblBacteriaiABD99652; ABD99652; LSL_0842.
GeneIDi3977772.
KEGGilsl:LSL_0842.
PATRICi22278587. VBILacSal43464_0916.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000233 Genomic DNA. Translation: ABD99652.1.
RefSeqiWP_011475989.1. NC_007929.1.
YP_535735.1. NC_007929.1.

3D structure databases

ProteinModelPortaliQ1WTW0.
SMRiQ1WTW0. Positions 3-550.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi362948.LSL_0842.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABD99652; ABD99652; LSL_0842.
GeneIDi3977772.
KEGGilsl:LSL_0842.
PATRICi22278587. VBILacSal43464_0916.

Phylogenomic databases

eggNOGiCOG2759.
HOGENOMiHOG000040280.
KOiK01938.
OMAiCMVKTHL.
OrthoDBiEOG6PCPSP.

Enzyme and pathway databases

UniPathwayiUPA00193.
BioCyciLSAL362948:GJDJ-919-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: UCC118.

Entry informationi

Entry nameiFTHS_LACS1
AccessioniPrimary (citable) accession number: Q1WTW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: May 2, 2006
Last modified: April 1, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.