Q1WTS7 (PLSY_LACS1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glycerol-3-phosphate acyltransferase

Alternative name(s):
Acyl-PO4 G3P acyltransferase
Acyl-phosphate--glycerol-3-phosphate acyltransferase
G3P acyltransferase
Short name=GPAT
EC=2.3.1.n3
Lysophosphatidic acid synthase
Short name=LPA synthase

Gene names

Name:	plsY
Ordered Locus Names:	LSL_0870

Organism

Lactobacillus salivarius (strain UCC118) [Complete proteome] [HAMAP]

Taxonomic identifier

362948 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Lactobacillaceae › Lactobacillus › Lactobacillus salivarius

Protein attributes

Sequence length	206 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO4) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP By similarity. HAMAP-Rule MF_01043
Catalytic activity	Acyl-phosphate + sn-glycerol 3-phosphate = 1-acyl-sn-glycerol 3-phosphate + phosphate. HAMAP-Rule MF_01043
Pathway	Lipid metabolism; phospholipid metabolism. HAMAP-Rule MF_01043
Subunit structure	Probably interacts with PlsX By similarity. HAMAP-Rule MF_01043
Subcellular location	Cell membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_01043.
Sequence similarities	Belongs to the PlsY family.

Ontologies

Keywords
Biological process	Lipid biosynthesis Lipid metabolism Phospholipid biosynthesis Phospholipid metabolism
Cellular component	Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	phospholipid biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	acyl-phosphate glycerol-3-phosphate acyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 206	206	Glycerol-3-phosphate acyltransferase HAMAP-Rule MF_01043		PRO_0000250308
Regions
	Transmembrane	5 – 25	21	Helical; Potential
	Transmembrane	56 – 76	21	Helical; Potential
	Transmembrane	81 – 101	21	Helical; Potential
	Transmembrane	111 – 131	21	Helical; Potential
	Transmembrane	161 – 181	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	Q1WTS7 [UniParc]. Last modified May 2, 2006. Version 1. Checksum: 34F56470E398F6D8	FASTA	206	22,786
	10 20 30 40 50 60 MDIKIILMLI IGYLLGSIPS GVWIGKIFYN KDIRNYGSGN MGTTNTFRVL GKKAGIVVLL 70 80 90 100 110 120 MDMLKGTITA CLPFIFHVNV SVLLIGLSAI LGHVFPIFAG FRGGKAVATS VGVLLVYNPL 130 140 150 160 170 180 FFTIAWAIFI ITLYISSMVS VASMLGFTLV SIISLFFNDR VLTIVAIVLT VFVFARHWKN 190 200 IERIKNGTEN MVPFGLGYRR RQKNTK

References

[1]

"Multireplicon genome architecture of Lactobacillus salivarius." Claesson M.J., Li Y., Leahy S., Canchaya C., van Pijkeren J.P., Cerdeno-Tarraga A.M., Parkhill J., Flynn S., O'Sullivan G.C., Collins J.K., Higgins D., Shanahan F., Fitzgerald G.F., van Sinderen D., O'Toole P.W. Proc. Natl. Acad. Sci. U.S.A. 103:6718-6723(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: UCC118.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000233 Genomic DNA. Translation: ABD99680.1.
RefSeq	YP_535763.1. NC_007929.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	362948.LSL_0870.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABD99680; ABD99680; LSL_0870.
GeneID	3977895.
KEGG	lsl:LSL_0870.
PATRIC	22278645. VBILacSal43464_0945.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0344.
HOGENOM	HOG000283807.
KO	K08591.
OMA	THRENII.
Enzyme and pathway databases
BioCyc	LSAL362948:GJDJ-948-MONOMER.
UniPathway	UPA00085.
Family and domain databases
HAMAP	MF_01043. PlsY.
InterPro	IPR003811. G3P_acylTferase. [Graphical view]
Pfam	PF02660. G3P_acyltransf. 1 hit. [Graphical view]
TIGRFAMs	TIGR00023. TIGR00023. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PLSY_LACS1

Accession

Primary (citable) accession number: Q1WTS7

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 19, 2006
Last sequence update:	May 2, 2006
Last modified:	May 1, 2013
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program