ID   ADEC_LACS1              Reviewed;         578 AA.
AC   Q1WTM3;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2006, sequence version 1.
DT   16-JUN-2009, entry version 20.
DE   RecName: Full=Adenine deaminase;
DE            Short=Adenase;
DE            Short=Adenine aminase;
DE            EC=3.5.4.2;
GN   Name=ade; OrderedLocusNames=LSL_0929;
OS   Lactobacillus salivarius subsp. salivarius (strain UCC118).
OC   Bacteria; Firmicutes; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=362948;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16617113; DOI=10.1073/pnas.0511060103;
RA   Claesson M.J., Li Y., Leahy S., Canchaya C., van Pijkeren J.P.,
RA   Cerdeno-Tarraga A.M., Parkhill J., Flynn S., O'Sullivan G.C.,
RA   Collins J.K., Higgins D., Shanahan F., Fitzgerald G.F.,
RA   van Sinderen D., O'Toole P.W.;
RT   "Multireplicon genome architecture of Lactobacillus salivarius.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:6718-6723(2006).
CC   -!- CATALYTIC ACTIVITY: Adenine + H(2)O = hypoxanthine + NH(3).
CC   -!- COFACTOR: Manganese (By similarity).
CC   -!- SIMILARITY: Belongs to the adenine deaminase family.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; CP000233; ABD99739.1; -; Genomic_DNA.
DR   RefSeq; YP_535822.1; -.
DR   GeneID; 3977483; -.
DR   GenomeReviews; CP000233_GR; LSL_0929.
DR   KEGG; lsl:LSL_0929; -.
DR   HOGENOM; Q1WTM3; -.
DR   OMA; Q1WTM3; PGKIITE.
DR   BioCyc; LSAL362948:LSL_0929-MON; -.
DR   GO; GO:0000034; F:adenine deaminase activity; IEA:HAMAP.
DR   GO; GO:0030145; F:manganese ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006146; P:adenine catabolic process; IEA:InterPro.
DR   HAMAP; MF_01518; -; 1.
DR   InterPro; IPR006679; Adenine_deam.
DR   InterPro; IPR006680; Amidohydro_1.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   ProDom; PD001248; Amidohydro_like; 1.
DR   TIGRFAMs; TIGR01178; ade; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Hydrolase; Manganese.
FT   CHAIN         1    578       Adenine deaminase.
FT                                /FTId=PRO_0000292386.
SQ   SEQUENCE   578 AA;  62987 MW;  68DDF35C205490A3 CRC64;
     MEKQKLIKLI DVAAGRKKAD LVLKNAKIVD VFQAKILTGD IAISDGYIAG IGGSYQGVVE
     CNYTGKYVAP GFIEAHIHIE SSYVSPEEFS RVFIPRGTTT ILADPHEIVN VAGLKGLDYM
     VNAAKNAKMD IRYMMPPCVP ATNFETSGAD LYADDMEDAL KTGEVDGLAE LMNFPGVINA
     DDKMIDEILM AKKYGARIDG HAPQVVGKDL NAYIAAGPAN DHECSTLEEA EERLARGMYL
     LLREGSVTQD LRKLLPIVNT ANSRRCLLSG DDVQAKTAIN KGHLDNSIRI CIDEGLNPIT
     AIQMATLNPA EYCGLNDRGA IAPGRRADMV VFESLEDFAV EETYILGEKL SQGNEYLGEV
     NYYPIDSVES SMHVKDFTRE KLQLHLNSDK VRAIGVVPGE VLTTEEHVTV KRDGDGNFVY
     NDQEDVTKIV VVERHHNTGN VNVNLLSGYG IKAGAIAISI GHDSHNIIAT GTNDDDIFMA
     VNELIKQEGG AVVVKDEKVI SRMELKIAGL MCNLPAEKMI AQQDALDEAV HEELGVPDNV
     NPVMTLSFMP LAVIPKLKIT DKGLVDVEKN AFVSNELD
//