Q1WTM3 (ADEC_LACS1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Adenine deaminase
Short name=Adenase
Short name=Adenine aminase
EC=3.5.4.2

Gene names

Name:	ade
Ordered Locus Names:	LSL_0929

Organism

Lactobacillus salivarius (strain UCC118) [Complete proteome] [HAMAP]

Taxonomic identifier

362948 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length	578 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Adenine + H2O = hypoxanthine + NH3. HAMAP MF_01518
Cofactor	Manganese By similarity. HAMAP MF_01518
Sequence similarities	Belongs to the adenine deaminase family.

Ontologies

Keywords
Ligand	Manganese
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	adenine catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	adenine deaminase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 578	578	Adenine deaminase HAMAP MF_01518		PRO_0000292386

Sequences

	Sequence		Length	Mass (Da)
	Q1WTM3 [UniParc]. Last modified May 2, 2006. Version 1. Checksum: 68DDF35C205490A3	FASTA	578	62,987
	10 20 30 40 50 60 MEKQKLIKLI DVAAGRKKAD LVLKNAKIVD VFQAKILTGD IAISDGYIAG IGGSYQGVVE 70 80 90 100 110 120 CNYTGKYVAP GFIEAHIHIE SSYVSPEEFS RVFIPRGTTT ILADPHEIVN VAGLKGLDYM 130 140 150 160 170 180 VNAAKNAKMD IRYMMPPCVP ATNFETSGAD LYADDMEDAL KTGEVDGLAE LMNFPGVINA 190 200 210 220 230 240 DDKMIDEILM AKKYGARIDG HAPQVVGKDL NAYIAAGPAN DHECSTLEEA EERLARGMYL 250 260 270 280 290 300 LLREGSVTQD LRKLLPIVNT ANSRRCLLSG DDVQAKTAIN KGHLDNSIRI CIDEGLNPIT 310 320 330 340 350 360 AIQMATLNPA EYCGLNDRGA IAPGRRADMV VFESLEDFAV EETYILGEKL SQGNEYLGEV 370 380 390 400 410 420 NYYPIDSVES SMHVKDFTRE KLQLHLNSDK VRAIGVVPGE VLTTEEHVTV KRDGDGNFVY 430 440 450 460 470 480 NDQEDVTKIV VVERHHNTGN VNVNLLSGYG IKAGAIAISI GHDSHNIIAT GTNDDDIFMA 490 500 510 520 530 540 VNELIKQEGG AVVVKDEKVI SRMELKIAGL MCNLPAEKMI AQQDALDEAV HEELGVPDNV 550 560 570 NPVMTLSFMP LAVIPKLKIT DKGLVDVEKN AFVSNELD

References

[1]

"Multireplicon genome architecture of Lactobacillus salivarius." Claesson M.J., Li Y., Leahy S., Canchaya C., van Pijkeren J.P., Cerdeno-Tarraga A.M., Parkhill J., Flynn S., O'Sullivan G.C., Collins J.K., Higgins D., Shanahan F., Fitzgerald G.F., van Sinderen D., O'Toole P.W. Proc. Natl. Acad. Sci. U.S.A. 103:6718-6723(2006) [PubMed: 16617113] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: UCC118.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000233 Genomic DNA. Translation: ABD99739.1.
RefSeq	YP_535822.1. NC_007929.1.
3D structure databases
ProteinModelPortal	Q1WTM3.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1WTM3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3977483.
GenomeReviews	Gene locus LSL_0929 in contig CP000233_GR.
KEGG	lsl:LSL_0929.
PATRIC	22278765. VBILacSal43464_1004.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1001.
HOGENOM	HBG725357.
OMA	GKIITEH.
PhylomeDB	Q1WTM3.
ProtClustDB	CLSK751279.
Family and domain databases
HAMAP	MF_01518. Adenine_deamin. [Tree]
InterPro	IPR006679. Adenine_deam. IPR006680. Amidohydro_1. IPR011059. Metal-dep_hydrolase_composite. [Graphical view]
KO	K01486.
Pfam	PF01979. Amidohydro_1. 1 hit. [Graphical view]
SUPFAM	SSF51338. Metalo_hydrolase. 1 hit.
TIGRFAMs	TIGR01178. Ade. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ADEC_LACS1

Accession

Primary (citable) accession number: Q1WTM3

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 26, 2007
Last sequence update:	May 2, 2006
Last modified:	January 25, 2012
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program