Reviewed, UniProtKB/Swiss-Prot Q1WTM3 (ADEC_LACS1)

Names and origin

Protein names

Recommended name:
    Adenine deaminase
      Short name=Adenase
      Short name=Adenine aminase
    EC=3.5.4.2

Gene names

Name:	ade
Ordered Locus Names:	LSL_0929

Organism

Lactobacillus salivarius subsp. salivarius (strain UCC118) [Complete proteome] [HAMAP]

Taxonomic identifier

362948 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length	578 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Adenine + H2O = hypoxanthine + NH3. HAMAP MF_01518
Cofactor	Manganese By similarity.
Sequence similarities	Belongs to the adenine deaminase family.

Ontologies

Keywords
Ligand	Manganese
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	adenine catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	adenine deaminase activity Inferred from electronic annotation. Source: HAMAP manganese ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 578	578	Adenine deaminase HAMAP MF_01518		PRO_0000292386

Sequences

	Sequence		Length	Mass (Da)
	Q1WTM3-1 [UniParc]. Last modified May 2, 2006. Version 1. Checksum: 68DDF35C205490A3	FASTA	578	62,987
	10 20 30 40 50 60 MEKQKLIKLI DVAAGRKKAD LVLKNAKIVD VFQAKILTGD IAISDGYIAG IGGSYQGVVE 70 80 90 100 110 120 CNYTGKYVAP GFIEAHIHIE SSYVSPEEFS RVFIPRGTTT ILADPHEIVN VAGLKGLDYM 130 140 150 160 170 180 VNAAKNAKMD IRYMMPPCVP ATNFETSGAD LYADDMEDAL KTGEVDGLAE LMNFPGVINA 190 200 210 220 230 240 DDKMIDEILM AKKYGARIDG HAPQVVGKDL NAYIAAGPAN DHECSTLEEA EERLARGMYL 250 260 270 280 290 300 LLREGSVTQD LRKLLPIVNT ANSRRCLLSG DDVQAKTAIN KGHLDNSIRI CIDEGLNPIT 310 320 330 340 350 360 AIQMATLNPA EYCGLNDRGA IAPGRRADMV VFESLEDFAV EETYILGEKL SQGNEYLGEV 370 380 390 400 410 420 NYYPIDSVES SMHVKDFTRE KLQLHLNSDK VRAIGVVPGE VLTTEEHVTV KRDGDGNFVY 430 440 450 460 470 480 NDQEDVTKIV VVERHHNTGN VNVNLLSGYG IKAGAIAISI GHDSHNIIAT GTNDDDIFMA 490 500 510 520 530 540 VNELIKQEGG AVVVKDEKVI SRMELKIAGL MCNLPAEKMI AQQDALDEAV HEELGVPDNV 550 560 570 NPVMTLSFMP LAVIPKLKIT DKGLVDVEKN AFVSNELD

References

[1]

"Multireplicon genome architecture of Lactobacillus salivarius." Claesson M.J., Li Y., Leahy S., Canchaya C., van Pijkeren J.P., Cerdeno-Tarraga A.M., Parkhill J., Flynn S., O'Sullivan G.C., Collins J.K., Higgins D., Shanahan F., Fitzgerald G.F., van Sinderen D., O'Toole P.W. Proc. Natl. Acad. Sci. U.S.A. 103:6718-6723(2006) [PubMed: 16617113] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000233 Genomic DNA. Translation: ABD99739.1.
RefSeq	YP_535822.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	3977483.
GenomeReviews	Gene locus LSL_0929 in contig CP000233_GR.
KEGG	lsl:LSL_0929.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q1WTM3.
OMA	Q1WTM3. PGKIITE.
Enzyme and pathway databases
BioCyc	LSAL362948:LSL_0929-MON.
Family and domain databases
HAMAP	MF_01518. [Tree]
InterPro	IPR006679. Adenine_deam. IPR006680. Amidohydro_1. [Graphical view]
Pfam	PF01979. Amidohydro_1. 1 hit. [Graphical view]
ProDom	PD001248. Amidohydro_like. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01178. ade. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ADEC_LACS1

Accession

Primary (citable) accession number: Q1WTM3

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 26, 2007
Last sequence update:	May 2, 2006
Last modified:	June 16, 2009
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)