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Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Lactobacillus salivarius (strain UCC118)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. Phosphoglycerate kinase (pgk)
  3. 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA), 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase (gpmA)
  4. Enolase (eno)
  5. Pyruvate kinase (pykF)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36SubstrateUniRule annotation1
Binding sitei119SubstrateUniRule annotation1
Binding sitei156SubstrateUniRule annotation1
Binding sitei211ATPUniRule annotation1
Binding sitei329ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi356 – 359ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
Gene namesi
Name:pgkUniRule annotation
Ordered Locus Names:LSL_1165
OrganismiLactobacillus salivarius (strain UCC118)
Taxonomic identifieri362948 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000006559 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000096251 – 400Phosphoglycerate kinaseAdd BLAST400

Proteomic databases

PRIDEiQ1WTB5

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi362948.LSL_1165

Structurei

3D structure databases

SMRiQ1WTB5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni21 – 23Substrate bindingUniRule annotation3
Regioni59 – 62Substrate bindingUniRule annotation4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105BZA Bacteria
COG0126 LUCA
HOGENOMiHOG000227107
KOiK00927
OMAiDMIFDIG
OrthoDBiPOG091H00YN

Family and domain databases

CDDicd00318 Phosphoglycerate_kinase, 1 hit
Gene3Di3.40.50.1260, 2 hits
HAMAPiMF_00145 Phosphoglyc_kinase, 1 hit
InterProiView protein in InterPro
IPR001576 Phosphoglycerate_kinase
IPR015911 Phosphoglycerate_kinase_CS
IPR015824 Phosphoglycerate_kinase_N
IPR036043 Phosphoglycerate_kinase_sf
PANTHERiPTHR11406 PTHR11406, 1 hit
PfamiView protein in Pfam
PF00162 PGK, 1 hit
PIRSFiPIRSF000724 Pgk, 1 hit
PRINTSiPR00477 PHGLYCKINASE
SUPFAMiSSF53748 SSF53748, 1 hit
PROSITEiView protein in PROSITE
PS00111 PGLYCERATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q1WTB5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKLIVSDLD VKGKKVLMRV DFNVPIKNGV IGNDNRIVAA LPTINYIIEH
60 70 80 90 100
DGKAILFSHL GRIKKEEDKK ELSLRPVAER LAELLNKPVT FVPATRGAQL
110 120 130 140 150
EDAINNMNDG DVLLVENTRF EDLDGKKESG NDPELGKYWA SLGDVFVNDA
160 170 180 190 200
FGTAHRSHAS NVGISEAMKA EGKQAAAGYL LEKEIKFLGN AVDSPKHPFV
210 220 230 240 250
AILGGAKVSD KIGVINHLLG KADKVIVGGG MTYTFYAAKG IKIGNSLVEK
260 270 280 290 300
DKIELAKEIM EKAGDKLVLP VDNVCAKEFN NDAPSEVVEG DIPDGYMALD
310 320 330 340 350
IGPKSVELFE DTLKDAKTVV WNGPMGVFEM SNFAKGTLEV GKFLGTLSDA
360 370 380 390 400
TTIVGGGDST AAVQQLGVAD KLTHISTGGG ASLEYLEGKT LPGIAAVSDK
Length:400
Mass (Da):42,647
Last modified:May 2, 2006 - v1
Checksum:i88A53DB0150E03FF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000233 Genomic DNA Translation: ABD99973.1
RefSeqiWP_003700618.1, NC_007929.1
YP_536056.1, NC_007929.1

Genome annotation databases

EnsemblBacteriaiABD99973; ABD99973; LSL_1165
GeneIDi3978000
KEGGilsl:LSL_1165
PATRICifig|362948.14.peg.1239

Similar proteinsi

Entry informationi

Entry nameiPGK_LACS1
AccessioniPrimary (citable) accession number: Q1WTB5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 2, 2006
Last modified: May 23, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health