Q1WSZ9 (GLMM_LACS1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoglucosamine mutase
EC=5.4.2.10

Gene names

Name:	glmM
Ordered Locus Names:	LSL_1144

Organism

Lactobacillus salivarius (strain UCC118) [Complete proteome] [HAMAP]

Taxonomic identifier

362948 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length	450 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate By similarity. HAMAP MF_01554_B
Catalytic activity	Alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate. HAMAP MF_01554_B
Cofactor	Binds 1 magnesium ion per subunit By similarity. HAMAP MF_01554_B
Post-translational modification	Activated by phosphorylation By similarity. HAMAP MF_01554_B
Sequence similarities	Belongs to the phosphohexose mutase family.

Ontologies

Keywords
Ligand	Magnesium Metal-binding
Molecular function	Isomerase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: InterPro phosphoglucosamine mutase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 450	450	Phosphoglucosamine mutase HAMAP MF_01554_B		PRO_0000305647
Sites
	Active site	101	1	Phosphoserine intermediate By similarity
	Metal binding	101	1	Magnesium; via phosphate group By similarity
	Metal binding	241	1	Magnesium By similarity
	Metal binding	243	1	Magnesium By similarity
	Metal binding	245	1	Magnesium By similarity
Amino acid modifications
	Modified residue	101	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1WSZ9 [UniParc]. Last modified May 2, 2006. Version 1. Checksum: E69399029F7CAA74	FASTA	450	48,571
	10 20 30 40 50 60 MKYFGTDGVR GIANETLSPE LAFKLGRCGG YVLTQHASNK PARVLVARDT RISGQMLEQA 70 80 90 100 110 120 LIAGLLSVGI EVFSLGVMTT PGVAYLVRLQ DADAGIMISA SHNPVQDNGI KFFGSDGYKL 130 140 150 160 170 180 SDEKEEEIEA LLESDEDTLP RPSAEGLGTL SDYREGALKY TQFLEQTIPD DLEGMHIAVD 190 200 210 220 230 240 GANGSTSALV SRLFADLGAD FDTMATNPDG LNINKGVGST HPEALAKFVV EKGAQVGVAF 250 260 270 280 290 300 DGDGDRCIAV DENGEIVDGD KIMFICGKYL SERGRLKKDT IVTTVMSNIG LYKAMKENNL 310 320 330 340 350 360 NSVQTKVGDR YVVEAMRKDG YNVGGEQSGH VVFLDFNTTG DGMLTALQLL NVIKQTGKKL 370 380 390 400 410 420 SELAAEVKTY PQELVNIKVT DKKAALDNEK IKEAIAKVEE KMAGDGRVLV RPSGTEDLLR 430 440 450 VMAEAKTQEL VHDYVMEIAD VVEAEMGVNE

References

[1]

"Multireplicon genome architecture of Lactobacillus salivarius." Claesson M.J., Li Y., Leahy S., Canchaya C., van Pijkeren J.P., Cerdeno-Tarraga A.M., Parkhill J., Flynn S., O'Sullivan G.C., Collins J.K., Higgins D., Shanahan F., Fitzgerald G.F., van Sinderen D., O'Toole P.W. Proc. Natl. Acad. Sci. U.S.A. 103:6718-6723(2006) [PubMed: 16617113] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: UCC118.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000233 Genomic DNA. Translation: ABD99952.1.
RefSeq	YP_536035.1. NC_007929.1.
3D structure databases
ProteinModelPortal	Q1WSZ9.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1WSZ9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3977884.
GenomeReviews	Gene locus LSL_1144 in contig CP000233_GR.
KEGG	lsl:LSL_1144.
PATRIC	22279195. VBILacSal43464_1218.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1109.
HOGENOM	HBG644964.
OMA	PLEDIQV.
PhylomeDB	Q1WSZ9.
ProtClustDB	PRK14316.
Family and domain databases
HAMAP	MF_01554_B. GlmM_B. [Tree]
InterPro	IPR005844. A-D-PHexomutase_a/b/a-I. IPR016055. A-D-PHexomutase_a/b/a-I/II/III. IPR005845. A-D-PHexomutase_a/b/a-II. IPR005846. A-D-PHexomutase_a/b/a-III. IPR005843. A-D-PHexomutase_C. IPR016066. A-D-PHexomutase_CS. IPR005841. Alpha-D-phosphohexomutase_SF. IPR006352. GlmM. [Graphical view]
Gene3D	G3DSA:3.40.120.10. A-D-PHexomutase_a/b/a-I/II/III. 3 hits.
KO	K03431.
Pfam	PF02878. PGM_PMM_I. 1 hit. PF02879. PGM_PMM_II. 1 hit. PF02880. PGM_PMM_III. 1 hit. PF00408. PGM_PMM_IV. 1 hit. [Graphical view]
PRINTS	PR00509. PGMPMM.
SUPFAM	SSF53738. A-D-PHexomutase_a/b/a-I/II/III. 3 hits.
TIGRFAMs	TIGR01455. GlmM. 1 hit.
PROSITE	PS00710. PGM_PMM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLMM_LACS1

Accession

Primary (citable) accession number: Q1WSZ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 2, 2007
Last sequence update:	May 2, 2006
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program