Q1WSN1 (GLGA_LACS1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glycogen synthase
EC=2.4.1.21

Alternative name(s):
Starch [bacterial glycogen] synthase

Gene names

Name:	glgA
Ordered Locus Names:	LSL_1291

Organism

Lactobacillus salivarius (strain UCC118) [Complete proteome] [HAMAP]

Taxonomic identifier

362948 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Lactobacillales › Lactobacillaceae › Lactobacillus › Lactobacillus salivarius

Protein attributes

Sequence length	476 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Synthesizes alpha-1,4-glucan chains using ADP-glucose By similarity. HAMAP-Rule MF_00484
Catalytic activity	ADP-glucose + (1,4-alpha-D-glucosyl)(n) = ADP + (1,4-alpha-D-glucosyl)(n+1). HAMAP-Rule MF_00484
Pathway	Glycan biosynthesis; glycogen biosynthesis. HAMAP-Rule MF_00484
Sequence similarities	Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.

Ontologies

Keywords
Biological process	Glycogen biosynthesis
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	glycogen biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular_function	starch synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 476	476	Glycogen synthase HAMAP-Rule MF_00484		PRO_1000014368
Sites
	Binding site	15	1	ADP-glucose By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1WSN1 [UniParc]. Last modified May 2, 2006. Version 1. Checksum: 3926E6BDAE8F3185	FASTA	476	54,096
	10 20 30 40 50 60 MKLLFAGSEC APFFKTGGLG DVMGALPKTI AKTTDNDVRV VLPFFTGMAE EYKSQLSFVT 70 80 90 100 110 120 SFYVKVGWRD QYCGVLKLEM DNVTYYFIDN LYYFDRPGLY GYYDEGERWA FFQQAIIEML 130 140 150 160 170 180 EKIGFIPDIL HVNDYHTAFI PFLLKEKYGW INAYQSIKTV LTIHNLQFQG EYGREVLGEL 190 200 210 220 230 240 FNLDASYYDD GTVRFDTAVN FMKTGILYAD KVNTVSPTYA SEIQTEAFGQ GLDEILRMHN 250 260 270 280 290 300 WKLRGILNGI DYERNNPATD KNLVANYSAK KLKGKVKDKL ALQKEFGLPQ RKDVPVIAMV 310 320 330 340 350 360 SRLTAQKGFQ LVVSEMQNLV QFDVQVIVLG TGDANFEHDF RYFADTYPDK VGAAITFDVG 370 380 390 400 410 420 LAQRIYAGAD MFLMPSAFEP CGLSQMISMR YGTLPIVHQI GGLQDSVQPF NPVTGEGTGF 430 440 450 460 470 GFHDFSGFYM MQEIQEALRL YAESVAWTKV VKQAMSQDFS WETASQEYLN MYNELV

References

[1]

"Multireplicon genome architecture of Lactobacillus salivarius." Claesson M.J., Li Y., Leahy S., Canchaya C., van Pijkeren J.P., Cerdeno-Tarraga A.M., Parkhill J., Flynn S., O'Sullivan G.C., Collins J.K., Higgins D., Shanahan F., Fitzgerald G.F., van Sinderen D., O'Toole P.W. Proc. Natl. Acad. Sci. U.S.A. 103:6718-6723(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: UCC118.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000233 Genomic DNA. Translation: ABE00098.1.
RefSeq	YP_536181.1. NC_007929.1.
3D structure databases
ProteinModelPortal	Q1WSN1.
ModBase	Search...
Protein-protein interaction databases
STRING	362948.LSL_1291.
Protein family/group databases
CAZy	GT5. Glycosyltransferase Family 5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABE00098; ABE00098; LSL_1291.
GeneID	3976543.
KEGG	lsl:LSL_1291.
PATRIC	22279505. VBILacSal43464_1365.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0297.
HOGENOM	HOG000294940.
KO	K00703.
OMA	FDTVGWA.
ProtClustDB	PRK00654.
Enzyme and pathway databases
BioCyc	LSAL362948:GJDJ-1379-MONOMER.
UniPathway	UPA00164.
Family and domain databases
HAMAP	MF_00484. Glycogen_synth.
InterPro	IPR001296. Glyco_trans_1. IPR011835. Glycogen/starch_synth. IPR013534. Starch_synth_cat_dom. [Graphical view]
Pfam	PF08323. Glyco_transf_5. 1 hit. PF00534. Glycos_transf_1. 1 hit. [Graphical view]
TIGRFAMs	TIGR02095. glgA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GLGA_LACS1

Accession

Primary (citable) accession number: Q1WSN1

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 2, 2006
Last modified:	May 1, 2013
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program