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Protein

NAD kinase

Gene

nadK

Organism
Lactobacillus salivarius (strain UCC118)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei45Proton acceptorUniRule annotation1
Binding sitei148NADUniRule annotation1
Binding sitei150NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi45 – 46NADUniRule annotation2
Nucleotide bindingi122 – 123NADUniRule annotation2
Nucleotide bindingi161 – 166NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:LSL_1304
OrganismiLactobacillus salivarius (strain UCC118)
Taxonomic identifieri362948 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
Proteomesi
  • UP000006559 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10000598741 – 268NAD kinaseAdd BLAST268

Proteomic databases

PRIDEiQ1WSL8

Interactioni

Protein-protein interaction databases

STRINGi362948.LSL_1304

Structurei

3D structure databases

ProteinModelPortaliQ1WSL8
SMRiQ1WSL8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105F91 Bacteria
COG0061 LUCA
HOGENOMiHOG000275803
KOiK00858
OMAiNGIERMS
OrthoDBiPOG091H02D1

Family and domain databases

Gene3Di2.60.200.30, 1 hit
3.40.50.10330, 2 hits
HAMAPiMF_00361 NAD_kinase, 1 hit
InterProiView protein in InterPro
IPR017438 ATP-NAD_kinase_N
IPR017437 ATP-NAD_kinase_PpnK-typ_C
IPR016064 NAD/diacylglycerol_kinase_sf
IPR002504 NADK
PANTHERiPTHR20275 PTHR20275, 1 hit
PfamiView protein in Pfam
PF01513 NAD_kinase, 1 hit
SUPFAMiSSF111331 SSF111331, 1 hit

Sequencei

Sequence statusi: Complete.

Q1WSL8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRVGIFSNNV RRSLEVKAAL TRRFLERHFI IDDENPEVVV TIGGDGTLLS
60 70 80 90 100
AFHKYIDMLD KIRFVGVHTG HLGFYTDWRD DEIDDLVISL QSDNGQSVSY
110 120 130 140 150
PLLDVFVTYK DSNKRDVFTA LNEATIRRIS STMVTDIFIG GEFFERFRGD
160 170 180 190 200
GLCVSTPTGS TAYNKSLGGA VVHPTLDVLQ LTEVSSINNR VFRTLSSPMI
210 220 230 240 250
IAPKDWITIE PEGAADFILT VDSDSYHKLK IKEIKFKISK KKIHFAKYRH
260
THFWHRVQTA FIGDEDAD
Length:268
Mass (Da):30,438
Last modified:May 2, 2006 - v1
Checksum:i1E65C7FD1AE7F971
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000233 Genomic DNA Translation: ABE00111.1
RefSeqiWP_011476267.1, NC_007929.1
YP_536194.1, NC_007929.1

Genome annotation databases

EnsemblBacteriaiABE00111; ABE00111; LSL_1304
GeneIDi3976556
KEGGilsl:LSL_1304
PATRICifig|362948.14.peg.1379

Similar proteinsi

Entry informationi

Entry nameiNADK_LACS1
AccessioniPrimary (citable) accession number: Q1WSL8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: May 2, 2006
Last modified: May 23, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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