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Q1WSL8

- NADK_LACS1

UniProt

Q1WSL8 - NADK_LACS1

Protein

NAD kinase

Gene

nadK

Organism
Lactobacillus salivarius (strain UCC118)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 58 (01 Oct 2014)
      Sequence version 1 (02 May 2006)
      Previous versions | rss
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    Functioni

    Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

    Catalytic activityi

    ATP + NAD+ = ADP + NADP+.UniRule annotation

    Cofactori

    Divalent metal ions.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei45 – 451Proton acceptorUniRule annotation
    Binding sitei148 – 1481NADUniRule annotation
    Binding sitei150 – 1501NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi45 – 462NADUniRule annotation
    Nucleotide bindingi122 – 1232NADUniRule annotation
    Nucleotide bindingi161 – 1666NADUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD+ kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD metabolic process Source: InterPro
    2. NADP biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Ligandi

    ATP-binding, NAD, NADP, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciLSAL362948:GJDJ-1392-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
    Alternative name(s):
    ATP-dependent NAD kinaseUniRule annotation
    Gene namesi
    Name:nadKUniRule annotation
    Ordered Locus Names:LSL_1304
    OrganismiLactobacillus salivarius (strain UCC118)
    Taxonomic identifieri362948 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000006559: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 268268NAD kinasePRO_1000059874Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi362948.LSL_1304.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1WSL8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAD kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0061.
    HOGENOMiHOG000275803.
    KOiK00858.
    OMAiIQMSEIA.
    OrthoDBiEOG6PZXDR.

    Family and domain databases

    Gene3Di2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPiMF_00361. NAD_kinase.
    InterProiIPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view]
    PANTHERiPTHR20275. PTHR20275. 1 hit.
    PfamiPF01513. NAD_kinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF111331. SSF111331. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q1WSL8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRVGIFSNNV RRSLEVKAAL TRRFLERHFI IDDENPEVVV TIGGDGTLLS    50
    AFHKYIDMLD KIRFVGVHTG HLGFYTDWRD DEIDDLVISL QSDNGQSVSY 100
    PLLDVFVTYK DSNKRDVFTA LNEATIRRIS STMVTDIFIG GEFFERFRGD 150
    GLCVSTPTGS TAYNKSLGGA VVHPTLDVLQ LTEVSSINNR VFRTLSSPMI 200
    IAPKDWITIE PEGAADFILT VDSDSYHKLK IKEIKFKISK KKIHFAKYRH 250
    THFWHRVQTA FIGDEDAD 268
    Length:268
    Mass (Da):30,438
    Last modified:May 2, 2006 - v1
    Checksum:i1E65C7FD1AE7F971
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000233 Genomic DNA. Translation: ABE00111.1.
    RefSeqiYP_536194.1. NC_007929.1.

    Genome annotation databases

    EnsemblBacteriaiABE00111; ABE00111; LSL_1304.
    GeneIDi3976556.
    KEGGilsl:LSL_1304.
    PATRICi22279533. VBILacSal43464_1379.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000233 Genomic DNA. Translation: ABE00111.1 .
    RefSeqi YP_536194.1. NC_007929.1.

    3D structure databases

    ProteinModelPortali Q1WSL8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 362948.LSL_1304.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE00111 ; ABE00111 ; LSL_1304 .
    GeneIDi 3976556.
    KEGGi lsl:LSL_1304.
    PATRICi 22279533. VBILacSal43464_1379.

    Phylogenomic databases

    eggNOGi COG0061.
    HOGENOMi HOG000275803.
    KOi K00858.
    OMAi IQMSEIA.
    OrthoDBi EOG6PZXDR.

    Enzyme and pathway databases

    BioCyci LSAL362948:GJDJ-1392-MONOMER.

    Family and domain databases

    Gene3Di 2.60.200.30. 1 hit.
    3.40.50.10330. 1 hit.
    HAMAPi MF_00361. NAD_kinase.
    InterProi IPR017438. ATP-NAD_kinase_dom_1.
    IPR016064. ATP-NAD_kinase_PpnK-typ.
    IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
    IPR002504. PolyP/ATP_NADK.
    [Graphical view ]
    PANTHERi PTHR20275. PTHR20275. 1 hit.
    Pfami PF01513. NAD_kinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF111331. SSF111331. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: UCC118.

    Entry informationi

    Entry nameiNADK_LACS1
    AccessioniPrimary (citable) accession number: Q1WSL8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 5, 2008
    Last sequence update: May 2, 2006
    Last modified: October 1, 2014
    This is version 58 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3