ID   COAA_LACS1              Reviewed;         306 AA.
AC   Q1WRY7;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2006, sequence version 1.
DT   16-JUN-2009, entry version 22.
DE   RecName: Full=Pantothenate kinase;
DE            EC=2.7.1.33;
DE   AltName: Full=Pantothenic acid kinase;
GN   Name=coaA; OrderedLocusNames=LSL_1538;
OS   Lactobacillus salivarius subsp. salivarius (strain UCC118).
OC   Bacteria; Firmicutes; Lactobacillales; Lactobacillaceae;
OC   Lactobacillus.
OX   NCBI_TaxID=362948;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16617113; DOI=10.1073/pnas.0511060103;
RA   Claesson M.J., Li Y., Leahy S., Canchaya C., van Pijkeren J.P.,
RA   Cerdeno-Tarraga A.M., Parkhill J., Flynn S., O'Sullivan G.C.,
RA   Collins J.K., Higgins D., Shanahan F., Fitzgerald G.F.,
RA   van Sinderen D., O'Toole P.W.;
RT   "Multireplicon genome architecture of Lactobacillus salivarius.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:6718-6723(2006).
CC   -!- CATALYTIC ACTIVITY: ATP + (R)-pantothenate = ADP + (R)-4'-
CC       phosphopantothenate.
CC   -!- PATHWAY: Cofactor biosynthesis; coenzyme A biosynthesis; coenzyme
CC       A from pantothenate: step 1/5.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Probable).
CC   -!- SIMILARITY: Belongs to the prokaryotic pantothenate kinase family.
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DR   EMBL; CP000233; ABE00342.1; -; Genomic_DNA.
DR   RefSeq; YP_536425.1; -.
DR   GeneID; 3976687; -.
DR   GenomeReviews; CP000233_GR; LSL_1538.
DR   KEGG; lsl:LSL_1538; -.
DR   HOGENOM; Q1WRY7; -.
DR   OMA; Q1WRY7; PKVDLIT.
DR   BioCyc; LSAL362948:LSL_1538-MON; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:HAMAP.
DR   GO; GO:0004594; F:pantothenate kinase activity; IEA:HAMAP.
DR   GO; GO:0015937; P:coenzyme A biosynthetic process; IEA:HAMAP.
DR   HAMAP; MF_00215; -; 1.
DR   InterPro; IPR004566; PanK_bact.
DR   PANTHER; PTHR10285:SF7; PanK_bact; 1.
DR   PIRSF; PIRSF000545; Pantothenate_kin; 1.
DR   TIGRFAMs; TIGR00554; panK_bact; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Coenzyme A biosynthesis; Complete proteome; Cytoplasm;
KW   Kinase; Nucleotide-binding; Transferase.
FT   CHAIN         1    306       Pantothenate kinase.
FT                                /FTId=PRO_1000043222.
FT   NP_BIND      90     97       ATP (Potential).
SQ   SEQUENCE   306 AA;  36089 MW;  E838A298753D2374 CRC64;
     MENRLNYYKI ERDEWSNFYQ EHIVPLTEEE LLNLKSLNDQ ISLKDVQDIY MPLVHLLRIH
     LDSHQELQDS QSEFLGVKAQ KVPFILGIAG SVAVGKSTTA RLLQSLLSEV YPDKKVQLIT
     TDGFLYPNQE LKRRNLMERK GFPESYDMRR LLRFVNDVKN NLPAKAPVYS HKVYDIVKGQ
     YEIVESPDIL IVEGINVLQL PTNQQIYVSD FFDFSIYVDA EESLIEEWYL ERFETLLDTA
     FKDPTNYYYP YAIGDRKQAI KMAKNIWKTI NLKNLREFIL PTRNRADLIM HKTNNHVVNE
     LFLRKY
//