Q1WRY7 (COAA_LACS1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pantothenate kinase
EC=2.7.1.33

Alternative name(s):
Pantothenic acid kinase

Gene names

Name:	coaA
Ordered Locus Names:	LSL_1538

Organism

Lactobacillus salivarius (strain UCC118) [Complete proteome] [HAMAP]

Taxonomic identifier

362948 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length	306 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + (R)-pantothenate = ADP + (R)-4'-phosphopantothenate. HAMAP MF_00215
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 1/5. HAMAP MF_00215
Subcellular location	Cytoplasm Probable HAMAP MF_00215.
Sequence similarities	Belongs to the prokaryotic pantothenate kinase family.

Ontologies

Keywords
Biological process	Coenzyme A biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW pantothenate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 306	306	Pantothenate kinase HAMAP MF_00215		PRO_1000043222
Regions
	Nucleotide binding	90 – 97	8	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	Q1WRY7 [UniParc]. Last modified May 2, 2006. Version 1. Checksum: E838A298753D2374	FASTA	306	36,089
	10 20 30 40 50 60 MENRLNYYKI ERDEWSNFYQ EHIVPLTEEE LLNLKSLNDQ ISLKDVQDIY MPLVHLLRIH 70 80 90 100 110 120 LDSHQELQDS QSEFLGVKAQ KVPFILGIAG SVAVGKSTTA RLLQSLLSEV YPDKKVQLIT 130 140 150 160 170 180 TDGFLYPNQE LKRRNLMERK GFPESYDMRR LLRFVNDVKN NLPAKAPVYS HKVYDIVKGQ 190 200 210 220 230 240 YEIVESPDIL IVEGINVLQL PTNQQIYVSD FFDFSIYVDA EESLIEEWYL ERFETLLDTA 250 260 270 280 290 300 FKDPTNYYYP YAIGDRKQAI KMAKNIWKTI NLKNLREFIL PTRNRADLIM HKTNNHVVNE LFLRKY

References

[1]

"Multireplicon genome architecture of Lactobacillus salivarius." Claesson M.J., Li Y., Leahy S., Canchaya C., van Pijkeren J.P., Cerdeno-Tarraga A.M., Parkhill J., Flynn S., O'Sullivan G.C., Collins J.K., Higgins D., Shanahan F., Fitzgerald G.F., van Sinderen D., O'Toole P.W. Proc. Natl. Acad. Sci. U.S.A. 103:6718-6723(2006) [PubMed: 16617113] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: UCC118.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000233 Genomic DNA. Translation: ABE00342.1.
RefSeq	YP_536425.1. NC_007929.1.
3D structure databases
ProteinModelPortal	Q1WRY7.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1WRY7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3976687.
GenomeReviews	Gene locus LSL_1538 in contig CP000233_GR.
KEGG	lsl:LSL_1538.
PATRIC	22280045. VBILacSal43464_1629.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1072.
HOGENOM	HBG732538.
OMA	EVYLPLS.
PhylomeDB	Q1WRY7.
ProtClustDB	PRK05439.
Family and domain databases
HAMAP	MF_00215. Pantothen_kinase_1. [Tree]
InterPro	IPR004566. PanK_bact. IPR006083. PRK/URK. [Graphical view]
KO	K00867.
PANTHER	PTHR10285:SF7. PanK_bact. 1 hit.
Pfam	PF00485. PRK. 1 hit. [Graphical view]
PIRSF	PIRSF000545. Pantothenate_kin. 1 hit.
TIGRFAMs	TIGR00554. PanK_bact. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COAA_LACS1

Accession

Primary (citable) accession number: Q1WRY7

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 2, 2006
Last modified:	January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program