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Q1WRR5

- PROB_LACS1

UniProt

Q1WRR5 - PROB_LACS1

Protein

Glutamate 5-kinase

Gene

proB

Organism
Lactobacillus salivarius (strain UCC118)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (02 May 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.UniRule annotation

    Catalytic activityi

    ATP + L-glutamate = ADP + L-glutamate 5-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei15 – 151ATPUniRule annotation
    Binding sitei55 – 551SubstrateUniRule annotation
    Binding sitei142 – 1421SubstrateUniRule annotation
    Binding sitei158 – 1581Substrate; via amide nitrogenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi178 – 1792ATPUniRule annotation
    Nucleotide bindingi220 – 2267ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glutamate 5-kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. L-proline biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Amino-acid biosynthesis, Proline biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciLSAL362948:GJDJ-1715-MONOMER.
    UniPathwayiUPA00098; UER00359.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamate 5-kinaseUniRule annotation (EC:2.7.2.11UniRule annotation)
    Alternative name(s):
    Gamma-glutamyl kinaseUniRule annotation
    Short name:
    GKUniRule annotation
    Gene namesi
    Name:proBUniRule annotation
    Ordered Locus Names:LSL_1612
    OrganismiLactobacillus salivarius (strain UCC118)
    Taxonomic identifieri362948 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus
    ProteomesiUP000006559: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 267267Glutamate 5-kinasePRO_0000252983Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi362948.LSL_1612.

    Structurei

    3D structure databases

    ProteinModelPortaliQ1WRR5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glutamate 5-kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0263.
    HOGENOMiHOG000246368.
    KOiK00931.
    OMAiTKETNHI.
    OrthoDBiEOG6PGK7G.

    Family and domain databases

    Gene3Di3.40.1160.10. 1 hit.
    HAMAPiMF_00456. ProB.
    InterProiIPR001048. Asp/Glu/Uridylate_kinase.
    IPR001057. Glu/AcGlu_kinase.
    IPR011529. Glu_5kinase.
    IPR005715. Glu_5kinase/COase_Synthase.
    [Graphical view]
    PfamiPF00696. AA_kinase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000729. GK. 1 hit.
    PRINTSiPR00474. GLU5KINASE.
    SUPFAMiSSF53633. SSF53633. 1 hit.
    TIGRFAMsiTIGR01027. proB. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q1WRR5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MENRNLQDAK RIVVKVGTSS LIRANGKINL QAIDELCYTL SGLVNEDKEV    50
    VLVSSGAVGV GLANMGLVQR PKQIPEQQAL AAIGQSQLMT IYQQRFAMYS 100
    QKTSQILLTH DVLTYPESRE NVLNTFNELL KWKVIPVVNE NDTVAVDEMD 150
    HQTSFGDNDW LSAVVASGID ADLLIVLSDI DGLFNKNPKK YADANLISEV 200
    TEINEKITGA AGGTGSRFGT GGMATKIKAM DRMINEGRKA VLANGKRPSI 250
    IFEILNGKQI GTLFHKK 267
    Length:267
    Mass (Da):29,162
    Last modified:May 2, 2006 - v1
    Checksum:iF81945230E8D15A3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000233 Genomic DNA. Translation: ABE00414.1.
    RefSeqiYP_536497.1. NC_007929.1.

    Genome annotation databases

    EnsemblBacteriaiABE00414; ABE00414; LSL_1612.
    GeneIDi3976765.
    KEGGilsl:LSL_1612.
    PATRICi22280201. VBILacSal43464_1707.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000233 Genomic DNA. Translation: ABE00414.1 .
    RefSeqi YP_536497.1. NC_007929.1.

    3D structure databases

    ProteinModelPortali Q1WRR5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 362948.LSL_1612.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABE00414 ; ABE00414 ; LSL_1612 .
    GeneIDi 3976765.
    KEGGi lsl:LSL_1612.
    PATRICi 22280201. VBILacSal43464_1707.

    Phylogenomic databases

    eggNOGi COG0263.
    HOGENOMi HOG000246368.
    KOi K00931.
    OMAi TKETNHI.
    OrthoDBi EOG6PGK7G.

    Enzyme and pathway databases

    UniPathwayi UPA00098 ; UER00359 .
    BioCyci LSAL362948:GJDJ-1715-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1160.10. 1 hit.
    HAMAPi MF_00456. ProB.
    InterProi IPR001048. Asp/Glu/Uridylate_kinase.
    IPR001057. Glu/AcGlu_kinase.
    IPR011529. Glu_5kinase.
    IPR005715. Glu_5kinase/COase_Synthase.
    [Graphical view ]
    Pfami PF00696. AA_kinase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000729. GK. 1 hit.
    PRINTSi PR00474. GLU5KINASE.
    SUPFAMi SSF53633. SSF53633. 1 hit.
    TIGRFAMsi TIGR01027. proB. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: UCC118.

    Entry informationi

    Entry nameiPROB_LACS1
    AccessioniPrimary (citable) accession number: Q1WRR5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 17, 2006
    Last sequence update: May 2, 2006
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3