Q1WRQ9 (MTLD_LACS1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mannitol-1-phosphate 5-dehydrogenase
EC=1.1.1.17

Gene names

Name:	mtlD
Ordered Locus Names:	LSL_1618

Organism

Lactobacillus salivarius (strain UCC118) [Complete proteome] [HAMAP]

Taxonomic identifier

362948 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length	382 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH. HAMAP MF_00196
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: EC nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 382	382	Mannitol-1-phosphate 5-dehydrogenase HAMAP MF_00196		PRO_1000011805
Regions
	Nucleotide binding	3 – 14	12	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1WRQ9 [UniParc]. Last modified May 2, 2006. Version 1. Checksum: 433ECC73F7C9FF0F	FASTA	382	42,778
	10 20 30 40 50 60 MRAVHFGAGN IGRGFIGETL AANGFGIDFV DVNDTIISAL NQRGEYDIEL AVPGQKKIHV 70 80 90 100 110 120 ENVDGINNGE HPEKVVEAIK TTDLVTTAIG PKILKFIAPL IADGIKARKD ADNKQTLDVI 130 140 150 160 170 180 ACENMIGGSQ HLKEEVYSHL DDDVKAFADE YIGFPNAAVD RIVPLQKHDD PLLVSVEEFK 190 200 210 220 230 240 EWVVDESQMK NPSLKLETVH YAPDLEPYIE RKLFSVNTGH ATVAYTGKAL GYETIGEAIK 250 260 270 280 290 300 DEKVLTQLKN TLKEIRSLLL AKWDFQEKEL EEYHDKIIGR FENPYISDEI ARVGRTPIRK 310 320 330 340 350 360 LGYDERFIRP IRELKARGLS YTTLMETVGK IYHFDEPKDD ESQKLQKMLK DEDLKDVIVE 370 380 TTGLKDDADL VAEIAASVKA AD

References

[1]

"Multireplicon genome architecture of Lactobacillus salivarius." Claesson M.J., Li Y., Leahy S., Canchaya C., van Pijkeren J.P., Cerdeno-Tarraga A.M., Parkhill J., Flynn S., O'Sullivan G.C., Collins J.K., Higgins D., Shanahan F., Fitzgerald G.F., van Sinderen D., O'Toole P.W. Proc. Natl. Acad. Sci. U.S.A. 103:6718-6723(2006) [PubMed: 16617113] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: UCC118.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000233 Genomic DNA. Translation: ABE00420.1.
RefSeq	YP_536503.1. NC_007929.1.
3D structure databases
ProteinModelPortal	Q1WRQ9.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1WRQ9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3976771.
GenomeReviews	Gene locus LSL_1618 in contig CP000233_GR.
KEGG	lsl:LSL_1618.
PATRIC	22280213. VBILacSal43464_1713.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0246.
HOGENOM	HBG568825.
OMA	FANTAVD.
PhylomeDB	Q1WRQ9.
ProtClustDB	PRK02318.
Family and domain databases
HAMAP	MF_00196. Mannitol_dehydrog. [Tree]
InterPro	IPR008927. 6-PGluconate_DH_C-like. IPR013328. DH_multihelical. IPR023028. Mannitol_1_phos_5_DH. IPR000669. Mannitol_DH. IPR013118. Mannitol_DH_C. IPR023027. Mannitol_DH_CS. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KO	K00009.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
SUPFAM	SSF48179. 6DGDH_C_like. 1 hit.
PROSITE	PS00974. MANNITOL_DHGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_LACS1

Accession

Primary (citable) accession number: Q1WRQ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 15, 2008
Last sequence update:	May 2, 2006
Last modified:	January 25, 2012
This is version 42 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program