Q1WRE4 (RHAB_LACS1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Rhamnulokinase
EC=2.7.1.5

Alternative name(s):
Rhamnulose kinase

Gene names

Name:	rhaB
Ordered Locus Names:	LSL_1752

Encoded on

Plasmid pMP118

Organism

Lactobacillus salivarius (strain UCC118) [Complete proteome] [HAMAP]

Taxonomic identifier

362948 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Lactobacillaceae › Lactobacillus

Protein attributes

Sequence length	485 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + L-rhamnulose = ADP + L-rhamnulose 1-phosphate. HAMAP MF_01535
Pathway	Carbohydrate degradation; L-rhamnose degradation; glycerone phosphate from L-rhamnose: step 2/3. HAMAP MF_01535
Sequence similarities	Belongs to the rhamnulokinase family.

Ontologies

Keywords
Biological process	Rhamnose metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Plasmid
Gene Ontology (GO)
Biological process	rhamnose catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW rhamnulokinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 485	485	Rhamnulokinase HAMAP MF_01535		PRO_0000292778
Regions
	Region	234 – 236	3	Substrate binding By similarity
Sites
	Binding site	12	1	ATP By similarity
	Binding site	257	1	ATP By similarity
	Binding site	294	1	Substrate By similarity
	Binding site	302	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q1WRE4 [UniParc]. Last modified May 2, 2006. Version 1. Checksum: ABD197EA0C062364	FASTA	485	54,821
	10 20 30 40 50 60 MKAYVAVDIG ASSGRLMLGQ LEDGKLKLQE MHRFKNGFEF KNNHDRWNID YLIDEIFKGL 70 80 90 100 110 120 EKIKESGYTE VSLGIDTWAV DYVLVGKDGK KLQDPISYRD KRTSNSINEL TTEVSKEYIY 130 140 150 160 170 180 KKTGIQFLNF NTLYQLFEED KELLKKTDKI MMIPDYIGYI LTGKAVTEIT NASTTQMLSL 190 200 210 220 230 240 REGLFDKNLL EKVNVSSDQF AKLVDAGTVL GNLKEDWYSK YELPKVNVVT VATHDTASAV 250 260 270 280 290 300 IGTPCEGQHW AYLSSGTWSL IGTELNIPEN GAKVFKENYT NEWGAYGTYR FLKNIMGLWM 310 320 330 340 350 360 AQCVKKELND QYSFSELAEL AGEVEPFEQF INVNDQRFQN PGNMIQEIQT YCRETGQKVP 370 380 390 400 410 420 ETPGEIMMAI YSNLALFYAN EISKLDDIMG YHIDTLNIVG GGSNVALMNQ LTSTIANVDV 430 440 450 460 470 480 YAGPSEATAI GNILVQMITA GDVLNVYLGR RIISNSFDIK HYTPEQGKYS KVLAEYQQFL NKERG

References

[1]

"Multireplicon genome architecture of Lactobacillus salivarius." Claesson M.J., Li Y., Leahy S., Canchaya C., van Pijkeren J.P., Cerdeno-Tarraga A.M., Parkhill J., Flynn S., O'Sullivan G.C., Collins J.K., Higgins D., Shanahan F., Fitzgerald G.F., van Sinderen D., O'Toole P.W. Proc. Natl. Acad. Sci. U.S.A. 103:6718-6723(2006) [PubMed: 16617113] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: UCC118.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000234 Genomic DNA. Translation: ABE00554.1.
RefSeq	YP_536637.1. NC_007930.1.
3D structure databases
ProteinModelPortal	Q1WRE4.
ModBase	Search...
Protein-protein interaction databases
STRING	Q1WRE4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	3978502.
GenomeReviews	Gene locus LSL_1752 in contig CP000234_GR.
KEGG	lsl:LSL_1752.
PATRIC	22280540. VBILacSal43464_1857.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1070.
HOGENOM	HBG313195.
OMA	KENYTNE.
PhylomeDB	Q1WRE4.
ProtClustDB	CLSK447404.
Family and domain databases
HAMAP	MF_01535. Rhamnulokinase. [Tree]
InterPro	IPR000577. Carb_kinase_FGGY. IPR018485. Carb_kinase_FGGY_C. IPR018484. Carb_kinase_FGGY_N. IPR013449. Rhamnulokinase. [Graphical view]
KO	K00848.
PANTHER	PTHR10196. FGGY_kin. 1 hit.
Pfam	PF02782. FGGY_C. 1 hit. PF00370. FGGY_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR02627. Rhamnulo_kin. 1 hit.
ProtoNet	Search...

Entry information

Entry name

RHAB_LACS1

Accession

Primary (citable) accession number: Q1WRE4

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 26, 2007
Last sequence update:	May 2, 2006
Last modified:	January 25, 2012
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program